Materials,
Journal Year:
2024,
Volume and Issue:
17(21), P. 5163 - 5163
Published: Oct. 23, 2024
The
fatigue
behavior
of
metal
specimens
is
influenced
by
defects,
material
properties,
and
loading.
This
study
aims
to
establish
a
multi-scale
crack
growth
model
that
describes
physically
short
(PSC)
long
(LC)
behavior.
allows
the
calculation
rates
for
uniaxial
loading
at
different
stress
ratios
based
on
properties
specimen
geometry.
Furthermore,
integrates
Gaussian
distribution
theory
consider
heterogeneity
experimental
measurement
errors
cause
scatter.
rate
life
with
notch
geometry
were
predicted.
curves
generated
mainly
consistent
test
data
from
published
literature
PSC
LC
stages.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
Microtubules
are
cytoskeletal
filaments
that
provide
structural
support
for
numerous
cellular
processes.
Despite
their
high
rigidity,
microtubules
can
be
dramatically
bent
in
cells
and
it
is
unknown
how
much
force
a
microtubule
withstand
before
breaking.
We
find
liquid-liquid
phase
separation
of
the
kinesin-3
motor
KIF1C
results
multi-kinesin
clusters
entangle
neighboring
impose
level
mechanical
stress
breakage
disassembly.
Combining
computational
simulations
experiments,
we
show
fragmentation
enhanced
by
having
highly
processive
kinesin
domain,
stiff
clustering
mechanism,
sufficient
drag
on
microtubules.
estimate
rupture
70-120
pN,
which
lower
than
previous
estimates
based
vitro
studies
with
taxol-stabilized
These
indicate
presence
multiple
kinesins
cargo
has
potential
to
cause
breakage.
propose
mechanisms
exist
protect
integrity
releasing
either
motor-cargo
or
motor-microtubule
interaction,
thereby
preventing
accumulation
upon
engagement
multi-motor
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 28, 2025
The
accurate
calibration
of
semi-empirical
fatigue
models
against
experimental
evidence
is
a
critical
step
for
achieving
reliable
predictions.
Amongst
many
models,
El
Haddad's
(EH)
curve
widely
exploited
to
characterise
the
endurance
limit
defect-laden
and
cracked
metallic
alloys.
A
few
deterministic
computational
exist
in
this
respect,
however,
they
lack
robust
probabilistic
perspective
their
implementation
code
not
publicly
accessible.
authors
present
work
have
recently
Maximum
Posteriori
(MAP)
robustly
probabilistically
estimate
EH's
curves,
even
case
data
scarcity
or
incomplete
datasets,
combining
prior
knowledge
taken
from
literature.
Whilst
scheme
was
published,
associated
made
available.
Hereby,
B-FADE,
flexible
open-source
Python
package,
aimed
at
releasing
MAP
approach
with
improvements,
as
well
several
pre-
post-processing
utilities
facilitate
its
deployment.
package
conferred
sufficient
level
abstraction,
thus
turning
out
be
easily
extensible
future
other
relevant
models.
International Journal of Structural Integrity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 28, 2025
Purpose
During
the
service
life,
engineering
materials
often
suffer
from
alternating
loading
different
directions
simultaneously,
causing
unexpected
multiaxial
fatigue
damage.
In
response
to
this
issue,
scholars
measure
differences
in
paths
through
quantitative
evaluation
of
non-proportional
loading.
However,
how
accurately
describe
effects
remains
a
key
concern.
Design/methodology/approach
This
review
introduces
influence
on
cyclic
deformation
and
life
materials,
followed
by
development
prediction
models,
which
covers
evolution
equivalent
strain
criteria,
energy
method
critical
plane
approach,
latest
data-physics
fusion-driven
methods.
Findings
From
perspective
material
damage,
series
methods
including
strain,
density,
have
been
developed
for
evaluating
structures.
With
data-driven
algorithms,
physical-informed
neural
networks
also
based
these
empirical
models
obtain
more
accurate
results.
future
research,
studies
that
integrate
physical
mechanisms
with
can
provide
reliable
results
prediction.
Originality/value
classical
It
provides
reference
further
research
into
theories
