Biodegradation, mechanical and biocompatibility evaluation of compact and porous polylactic acid after long‐term dynamic fluid immersion DOI Creative Commons
D. V. Portan,

Andriani Angelopoulou,

Athanasia Koliadima

et al.

Journal of Chemical Technology & Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Abstract BACKGROUND Polylactic acid (PLA) is the most widely used thermoplastic in applications benefit of humans, such as biomedicine and food packaging. However, its behaviour when operating relevant environments has not been fully investigated. In this research, effect long‐term interaction between biocompatible PLA a physiological fluid was monitored. RESULTS The weight variation samples, well their micro‐ nanomechanical properties, were evaluated during immersion until dissolution. Scanning electron micrographs indicated degradation layer line from Day (D)3 onwards. More pronounced damage involved plasticization breakage noted after D14. samples started to decrease considerably first month immersion. Scaffolds dissolved D70 microscopic compression modulus decreased 100 45 MPa within 42 days Nanoindentation testing important surface properties (stiffness hardness) by immersion, especially case higher loading forces 3000 μΝ. Biomarker analysis stem cells deposited on substrates revealed correlation material profile biomarkers variations. CONCLUSIONS biodegradation rate mechanical performance both compact porous investigated cell culture medium, which closely mimics body composition, dynamic environment involving stirring conditions temperature. A found at microscale with nanoscale events feedback. © 2025 Author(s). Journal Chemical Technology Biotechnology published John Wiley & Sons Ltd behalf Society Industry (SCI).

Language: Английский

Biodegradation, mechanical and biocompatibility evaluation of compact and porous polylactic acid after long‐term dynamic fluid immersion DOI Creative Commons
D. V. Portan,

Andriani Angelopoulou,

Athanasia Koliadima

et al.

Journal of Chemical Technology & Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Abstract BACKGROUND Polylactic acid (PLA) is the most widely used thermoplastic in applications benefit of humans, such as biomedicine and food packaging. However, its behaviour when operating relevant environments has not been fully investigated. In this research, effect long‐term interaction between biocompatible PLA a physiological fluid was monitored. RESULTS The weight variation samples, well their micro‐ nanomechanical properties, were evaluated during immersion until dissolution. Scanning electron micrographs indicated degradation layer line from Day (D)3 onwards. More pronounced damage involved plasticization breakage noted after D14. samples started to decrease considerably first month immersion. Scaffolds dissolved D70 microscopic compression modulus decreased 100 45 MPa within 42 days Nanoindentation testing important surface properties (stiffness hardness) by immersion, especially case higher loading forces 3000 μΝ. Biomarker analysis stem cells deposited on substrates revealed correlation material profile biomarkers variations. CONCLUSIONS biodegradation rate mechanical performance both compact porous investigated cell culture medium, which closely mimics body composition, dynamic environment involving stirring conditions temperature. A found at microscale with nanoscale events feedback. © 2025 Author(s). Journal Chemical Technology Biotechnology published John Wiley & Sons Ltd behalf Society Industry (SCI).

Language: Английский

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