Assessment of Polycyclic Aromatic Hydrocarbon Exposure in Trainee Firefighters Using PAH CALUX Bioassay DOI Creative Commons

J P Grünfeld,

Peter Möller, Ulla Vogel

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(11), P. 825 - 825

Published: Nov. 18, 2024

This work investigated the application of a reporter gene bioassay in assessing polycyclic aromatic hydrocarbon (PAH) exposure trainee firefighters. In PAH CALUX bioassay, PAH-induced activation aryl receptor cell line is recorded by increased luminescence. A repeated measurement study was performed, collecting urine and skin wipe samples at two baseline sessions (spring autumn) after three firefighting sessions: one with wood fuel, gas without fire. The response expressed as benzo[a]pyrene equivalents, which compared to levels 16 EPA criteria PAHs 8 hydroxylated (OH-PAHs) quantified chromatography-tandem mass spectrometry techniques. Benzo[a]pyrene equivalents wipes indicated larger during session other sessions. showed non-significant effect sizes all sessions, whereas chemical analysis OH-PAH session. changes observed for fire suggest negligible from contaminated gear. conclusion, shows that firefighters were exposed higher potentially toxic training

Language: Английский

Integrative analyses of circulating microRNA expression profile in hexavalent chromium exposed workers - a cross-sectional study within the SafeChrom project DOI Creative Commons
Zheshun Jiang, Min Pan, Yishan Liu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137367 - 137367

Published: Jan. 1, 2025

Language: Английский

Citations

0
Assessment of Polycyclic Aromatic Hydrocarbon Exposure in Trainee Firefighters Using PAH CALUX Bioassay DOI Creative Commons

J P Grünfeld,

Peter Möller, Ulla Vogel

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(11), P. 825 - 825

Published: Nov. 18, 2024

This work investigated the application of a reporter gene bioassay in assessing polycyclic aromatic hydrocarbon (PAH) exposure trainee firefighters. In PAH CALUX bioassay, PAH-induced activation aryl receptor cell line is recorded by increased luminescence. A repeated measurement study was performed, collecting urine and skin wipe samples at two baseline sessions (spring autumn) after three firefighting sessions: one with wood fuel, gas without fire. The response expressed as benzo[a]pyrene equivalents, which compared to levels 16 EPA criteria PAHs 8 hydroxylated (OH-PAHs) quantified chromatography-tandem mass spectrometry techniques. Benzo[a]pyrene equivalents wipes indicated larger during session other sessions. showed non-significant effect sizes all sessions, whereas chemical analysis OH-PAH session. changes observed for fire suggest negligible from contaminated gear. conclusion, shows that firefighters were exposed higher potentially toxic training

Language: Английский

Citations

0