Understanding Ecological Systems Using Knowledge Graphs: An Application to Highly Pathogenic Avian Influenza
Bioinformatics Advances,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Ecological
systems
are
complex.
Representing
heterogeneous
knowledge
about
ecological
is
a
pervasive
challenge
because
data
generated
from
many
subdisciplines,
exist
in
disparate
sources,
and
only
capture
subset
of
interactions
underpinning
system
dynamics.
Knowledge
graphs
(KGs)
have
been
successfully
applied
to
organize
predict
new
linkages
complex
systems.
Though
not
previously
broadly
ecology,
KGs
much
offer
an
era
when
dynamics
responding
rapid
changes
across
multiple
scales.
We
developed
KG
demonstrate
the
method's
utility
for
problems
focused
on
highly
pathogenic
avian
influenza
(HPAI),
transmissible
virus
with
broad
host
range,
wide
geographic
distribution,
evolution
pandemic
potential.
describe
development
graph
include
related
HPAI
including
pathogen-host
associations,
species
distributions,
population
demographics,
using
semantic
ontology
that
defines
relationships
within
between
datasets.
use
perform
set
proof-of-concept
analyses
validating
method
identifying
patterns
ecology.
underscore
generalizable
value
ecology
ability
reveal
known
testable
hypotheses
support
deeper
mechanistic
understanding
The
code
available
under
MIT
License
GitHub
at
https://github.com/cghss-data-lab/uga-pipp.
Language: Английский
Evolution and mutational landscape of highly pathogenic avian influenza strain A(H5N1) in the current outbreak in the USA and global landscape
Virology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 110246 - 110246
Published: Sept. 1, 2024
Language: Английский
Understanding Ecological Systems Using Knowledge Graphs: An Application to Highly Pathogenic Avian Influenza
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Abstract
Ecological
systems
are
complex.
Representing
heterogeneous
knowledge
about
ecological
is
a
pervasive
challenge
because
data
generated
from
many
subdisciplines,
exist
in
disparate
sources,
and
only
capture
subset
of
important
interactions
underpinning
system
structure,
resilience,
dynamics.
Knowledge
graphs
have
been
successfully
applied
to
organize
systematically
predict
new
linkages
representing
unobserved
relationships
complex
systems.
Though
not
previously
broadly
ecology,
much
offer
an
era
global
change
when
dynamics
responding
rapid
changes
across
multiple
scales
simultaneously.
We
developed
graph
demonstrate
the
method’s
utility
for
problems
focused
on
highly
pathogenic
avian
influenza
(HPAI),
transmissible
virus
with
broad
animal
host
range,
wide
geographic
distribution,
evolution
pandemic
potential.
describe
development
include
range
related
HPAI
including
pathogen-host
associations,
species
distributions,
human
population
demographics,
using
semantic
ontology
that
defines
within
between
datasets.
use
perform
set
proof-of-concept
analyses
validating
method
identifying
features
underscoring
generalizable
value
ecology
their
revealing
known
entities
generating
testable
hypotheses
support
deeper
mechanistic
understanding
Language: Английский
Challenges in Influenza Control and Surveillance in the Republic of Kazakhstan
Journal for Research in Applied Sciences and Biotechnology,
Journal Year:
2024,
Volume and Issue:
3(5), P. 160 - 165
Published: Nov. 2, 2024
The
COVID-19
pandemic
has
significantly
disrupted
the
circulation
of
influenza
viruses
in
Kazakhstan,
highlighting
vulnerabilities
country’s
public
health
infrastructure.
This
review
critically
examines
challenges
faced
infiltrating
and
controlling
particularly
light
shifting
epidemiological
landscape
post-pandemic.
Key
issues
include
decline
cases
during
pandemic,
which
complicates
assessment
epidemiology,
vaccine
effectiveness,
planning
vaccination
campaigns.
Although
part
Global
Influenza
Hospital
Surveillance
Network
(GIHSN),
Kazakhstan's
surveillance
systems
face
data
collection,
coordination,
awareness
gaps.
discusses
prevalence
various
strains,
impact
zoonotic
infections,
necessity
for
improved
monitoring
frameworks.
Additionally,
historical
context
infectious
disease
control
Kazakhstan
is
explored,
emphasising
need
enhanced
international
collaboration
targeted
strategies.
findings
underscore
importance
robust
to
mitigate
risks
seasonal
influenza,
advocating
a
comprehensive
approach
safeguard
Kazakhstan.
Language: Английский