The Impact of COVID-19 Pandemic Waves on Maternal Health and Infant Outcomes—A Retrospective Cohort Study DOI Creative Commons
Gail Ohaegbulam, Kedra Wallace,

Wondwosen Yimer

et al.

Women, Journal Year: 2024, Volume and Issue: 4(4), P. 469 - 479

Published: Nov. 21, 2024

The initial presentation of COVID-19 to the world left many in medical community perplexed about its true nature and potential impact on individuals. Many investigations into pathology virus resulted from this; however, studies were limited obstetric community, especially high-risk communities. Each pandemic wave (Alpha, Delta, Omicron) had different transmission rates inflicted severity levels among those infected. This study aimed determine if effects maternal infant outcomes varied by waves. is an observational cohort utilizing women enrolled a pregnancy study. A review 374 electronic records who received care at University Mississippi Medical Center after testing positive for SARS-CoV2 was conducted. During Alpha wave, contracted significantly earlier pregnancy; higher infection occurred during Omicron wave. Delta more morbidly obese likely deliver earlier, and, when compared infants born weighed less. pregnant patients may deviate previous reports, indicating need further investigation biological social factors that lead these differences. Studies remain this provides valuable insight how varying strains affected community.

Language: Английский

SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development DOI Creative Commons
Fabrizio Angius,

Silvia Puxeddu,

S Zaimi

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 13(1), P. 17 - 17

Published: Dec. 28, 2024

The COVID-19 pandemic, driven by the rapid evolution of SARS-CoV-2 virus, presents ongoing challenges to global public health. is characterized rapidly evolving mutations, especially in (but not limited to) spike protein, complicating predictions about its evolutionary trajectory. These mutations have significantly affected transmissibility, immune evasion, and vaccine efficacy, leading multiple pandemic waves with over half a billion cases seven million deaths globally. Despite several strategies, from development administration design availability antivirals, including monoclonal antibodies, already having been employed, persistent circulation virus emergence new variants continue result high case numbers fatalities. In past four years, immense research efforts contributed much our understanding viral pathogenesis mechanism, syndrome, host-microbe interactions, effective vaccines, diagnostic tools, treatments. focus this review provide comprehensive analysis functional impact on diagnosis, treatments, effectiveness. We further discuss safety pregnancy implications hybrid immunity long-term protection against infection, as well latest developments pan-coronavirus nasal formulations, emphasizing need for continued surveillance, research, adaptive health strategies response race.

Language: Английский

Citations

4
SARS-CoV-2 infection in pregnant women and incidence of thromboembolic disease – an analysis of the Covid-19 Related Obstetric and Neonatal Outcome Study (CRONOS) in Germany DOI Creative Commons
Ulrich Pecks, Michael K. Bohlmann,

Kristin Andresen

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Purpose The aim of the present study was to quantify rate thromboembolic events (TE) in pregnant women with SARS-CoV-2 infection and characterize risk factors provide a basis for individualized recommendation on prophylactic measures. Methods CRONOS is multicenter, prospective observational conducted Germany Austria during COVID-19 pandemic. Pregnant confirmed were enrolled. Data demographics, medical history, COVID-19-related aspects, pregnancy birth outcomes collected. TE particularly queried used as primary outcome. A combination “TE,” “maternal or fetal death,” “severe postpartum hemorrhage” defined secondary endpoint. Risk analyses performed using univariate multivariable logistic regression models. Results from 8033 patients showed 40 TEs (0.5% incidence). rates 10% ICU patients, 0.2–0.4% those moderate-to-mild COVID-19, < 0.1% asymptomatic women. Pulmonary embolism occurred 21 cases, deep vein thrombosis 12, 7 had atypical arterial TE. included advanced gestational age, symptoms, hospitalization admission, premature birth, cesarean section, delivery within 4 weeks infection, higher weight gain, anemia, chronic inflammatory bowel disease. vaccination reduced risk. model yielded an AUC 0.87 (95% CI 0.81–0.94). Conclusion largely determined by severity In mild other outweigh risk, while severe requiring admission poses high despite prophylaxis.

Language: Английский

Citations

0
SARS-CoV-2 infection in pregnant women and incidence of thromboembolic disease: an analysis of the Covid-19-Related Obstetric and Neonatal Outcome Study (CRONOS) in Germany DOI Creative Commons
Ulrich Pecks, Michael K. Bohlmann,

Kristin Andresen

et al.

Archives of Gynecology and Obstetrics, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

The aim of the present study was to quantify rate thromboembolic events (TE) in pregnant women with SARS-CoV-2 infection and characterize risk factors provide a basis for individualized recommendation on prophylactic measures. CRONOS is multicenter, prospective observational conducted Germany Austria during COVID-19 pandemic. Pregnant confirmed were enrolled. Data demographics, medical history, COVID-19-related aspects, pregnancy birth outcomes collected. TE particularly queried used as primary outcome. A combination "TE," "maternal or fetal death," "severe postpartum hemorrhage" defined secondary endpoint. Risk analyses performed using univariate multivariable logistic regression models. from 8033 patients showed 40 TEs (0.5% incidence). rates 10% ICU patients, 0.2-0.4% those moderate-to-mild COVID-19, < 0.1% asymptomatic women. Pulmonary embolism occurred 21 cases, deep vein thrombosis 12, 7 had atypical arterial TE. included advanced gestational age, symptoms, hospitalization admission, premature birth, cesarean section, delivery within 4 weeks infection, higher weight gain, anemia, chronic inflammatory bowel disease. vaccination reduced risk. model yielded an AUC 0.87 (95% CI 0.81-0.94). largely determined by severity In mild other outweigh risk, while severe requiring admission poses high despite prophylaxis.

Language: Английский

Citations

0
KANET evaluation in patients with SARS-CoV-2 DOI
Zacharias Fasoulakis,

Asim Kurjak,

Ioakeim Sapantzoglou

et al.

Journal of Perinatal Medicine, Journal Year: 2024, Volume and Issue: 52(8), P. 811 - 816

Published: Aug. 29, 2024

Abstract Objectives To determine a possible correlation between SARS-CoV-2 infection during pregnancy and altered fetal behavior. Methods Kurjak’s antenatal neurodevelopmental test (KANET) was applied from 28 to 40 weeks in 38 gestations (group A) diagnosed with COVID-19 the first week 43 non-COVID pregnant women B). Results No statistically significant differences considering maternal age (33±3.9 years for group A vs. 31±4.1 B) gestational (33±1.6 compared 33±2.1 were observed. KANET scores not different two groups. Conclusions Fetal behavior are third trimester of pregnancy.

Language: Английский

Citations

0
COVID-19 in Pregnancy: Do Parturients Carry a High Risk of Adverse Maternal and Neonatal Outcomes? DOI Open Access
Sunil Pandya

Indian Journal of Critical Care Medicine, Journal Year: 2024, Volume and Issue: 28(10), P. 897 - 898

Published: Sept. 30, 2024

Pandya ST. COVID-19 in Pregnancy: Do Parturients Carry a High Risk of Adverse Maternal and Neonatal Outcomes? Indian J Crit Care Med 2024;28(10):897-898.

Language: Английский

Citations

0
Recent Vaccination Against SARS-CoV-2 Is Associated with Less Severe Disease in Working-Age Adults DOI Open Access

Kailey Fischer,

Joanne M. Langley, Robyn Harrison

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(11), P. 1501 - 1501

Published: Nov. 12, 2024

Essential workers, including those working in healthcare and education, are at higher risk of exposure to communicable diseases, SARS-CoV-2. Reducing the rates infection is important for their personal health ongoing safe operation essential services.

Language: Английский

Citations

0
Do timing and severity of gestational COVID-19 impact perinatal and neonatal outcomes? DOI
Júlia Candel-Pau, Daniel Suqué-Tusell, Silvia Maya‐Enero

et al.

Journal of Perinatology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Language: Английский

Citations

0
The Impact of COVID-19 Pandemic Waves on Maternal Health and Infant Outcomes—A Retrospective Cohort Study DOI Creative Commons
Gail Ohaegbulam, Kedra Wallace,

Wondwosen Yimer

et al.

Women, Journal Year: 2024, Volume and Issue: 4(4), P. 469 - 479

Published: Nov. 21, 2024

The initial presentation of COVID-19 to the world left many in medical community perplexed about its true nature and potential impact on individuals. Many investigations into pathology virus resulted from this; however, studies were limited obstetric community, especially high-risk communities. Each pandemic wave (Alpha, Delta, Omicron) had different transmission rates inflicted severity levels among those infected. This study aimed determine if effects maternal infant outcomes varied by waves. is an observational cohort utilizing women enrolled a pregnancy study. A review 374 electronic records who received care at University Mississippi Medical Center after testing positive for SARS-CoV2 was conducted. During Alpha wave, contracted significantly earlier pregnancy; higher infection occurred during Omicron wave. Delta more morbidly obese likely deliver earlier, and, when compared infants born weighed less. pregnant patients may deviate previous reports, indicating need further investigation biological social factors that lead these differences. Studies remain this provides valuable insight how varying strains affected community.

Language: Английский

Citations

0