Advancing Non-Invasive Diagnosis of Oral Epithelial Dysplasia: Comparative Insights from In Vivo Optical Coherence Tomography and Histopathology

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1118 - 1118

Published: Feb. 9, 2025

Background: Oral epithelial dysplasia (OED) is considered one of the premalignant lesions for oral squamous cell carcinoma (OSCC), which five-year disease-free survival rate may vary widely. There has emerged in recent years, therefore, a significant niche optical coherence tomography (OCT) to non-invasively examine tissue morphology. The present study was conducted evaluate diagnostic performance OCT distinguishing between mild, moderate, and severe dysplasias situ (CIS) with histopathological correlations. Methods: This prospective, single-centre included 120 patients clinically suspicious lesions. All underwent vivo imaging followed by surgical excision examination. sensitivity, specificity, AUC (area under curve) were calculated as measures accuracy. Results: demonstrated high sensitivity specificity above 80% all grades dysplasia. values highest moderate at 0.91 mild 0.89. Bland–Altman analysis revealed degree agreement histopathology regarding tumour depth measurements. Interobserver substantial almost perfect, kappa ranging from 0.74 0.85. provided key features thickening, basement membrane disruption, architectural disorganization. These had good correlations grade dysplasia: r = 0.75–0.82, p < 0.001. Conclusions: an established technique that non-invasive nature diagnosis OED; it can provide fine differentiation among define margins lesion.

Language: Английский

The Impact of Oral Microbiota Changes on the Prognosis of Patients with Tracheostomy after Craniocerebral Trauma

Current Problems in Surgery, Journal Year: 2025, Volume and Issue: unknown, P. 101739 - 101739

Published: March 1, 2025

Language: Английский