Colloids and Surfaces A Physicochemical and Engineering Aspects,
Journal Year:
2024,
Volume and Issue:
688, P. 133550 - 133550
Published: Feb. 23, 2024
Loading
hydrophobic
drugs,
such
as
cyclosporine,
into
contact
lenses
for
dry
eye
treatment
is
challenging
due
to
low
drug
uptake
during
soaking
and
alterations
in
critical
lens
properties,
including
wettability,
water
content,
optical
transmission.
This
study
aimed
investigate
the
role
of
micelle
dynamics
enhancing
cyclosporine
loading
hyaluronic
acid
(HA)-contact
while
improving
their
properties.
The
findings
indicate
that
Pluronic®
F127
(342
nm)
Tween®
80
(296
micelles
could
encapsulate
within
core,
with
demonstrating
superior
surface
tension
on
Langmuir-Blodgett
trough
compared
80.
cyclosporine-loaded
(13.43–20.92
µg)
was
higher
without
(CY-CL
=
8.80
µg).
Moreover,
improved
lens's
angle
(wettability),
equilibrium
transmission
micelles.
vitro
test
showed
sustained
release
from
over
120
h
or
96
using
Pluronic®-micelles
80-micelles,
respectively.
In
animal
study,
0.05%
w/v
F127-CL
0.0015%
Tween
80-CL
an
initial
2.54
µg/ml
3.59
µg/ml,
respectively,
profile
extending
48
h.
Wear
micelle-laden
resulted
lower
levels
IL-6
drops.
conclusion,
demonstrated
greater
stability,
release,
outcomes
These
suggest
potential
micelles-laden
a
promising
alternative
drops
management.
This
study
provides
a
bibliometric
and
bibliographic
review
of
emerging
applications
micro-
nanotechnology
in
treating
ocular
diseases,
with
primary
focus
on
glaucoma.
We
aim
to
identify
key
research
trends
analyze
advancements
devices
drug
delivery
systems
for
treatments.
The
methodology
involved
analyzing
385
documents
indexed
the
Web
Science
using
tools
such
as
VOSviewer
Bibliometrix.
results
show
marked
increase
scientific
output,
highlighting
prominent
authors
institutions,
England
leading
field.
Key
findings
suggest
that
holds
potential
address
limitations
conventional
treatments,
including
low
bioavailability
adverse
side
effects.
Nanoparticles,
nanovesicles,
polymer-based
appear
promising
prolonged
controlled
release,
potentially
offering
enhanced
therapeutic
efficacy.
In
conclusion,
could
transform
disease
treatment,
although
challenges
remain
concerning
biocompatibility
scalability
these
devices.
Further
clinical
studies
are
necessary
establish
innovations
within
context
ophthalmology.
Frontiers in Chemistry,
Journal Year:
2022,
Volume and Issue:
10
Published: April 13, 2022
Ocular
disorders
comprising
various
diseases
of
the
anterior
and
posterior
segments
are
considered
as
main
reasons
for
blindness.
Natural
products
have
been
identified
potential
treatments
ocular
due
to
their
anti-oxidative,
antiangiogenic,
anti-inflammatory
effects.
Unfortunately,
most
these
beneficial
compounds
characterised
by
low
solubility
which
results
in
bioavailability
rapid
systemic
clearance
thus
requiring
frequent
administration
or
high
doses,
hinders
therapeutic
applications.
Additionally,
efficiency
drug
delivery
a
popular
route
treatment
is
restricted
anatomical
physiological
barriers.
Recently,
nanotechnology-based
strategies
including
polymeric
nanoparticles,
micelles,
nanofibers,
dendrimers,
lipid
liposomes,
niosomes
emerged
promising
approaches
overcome
limitations
enhance
effective
target
sites.
This
review
provides
an
overview
nano-drug
systems
natural
such
thymoquinone,
catechin,
epigallocatechin
gallate,
curcumin,
berberine,
pilocarpine,
genistein,
resveratrol,
quercetin,
naringenin,
lutein,
kaempferol,
baicalin,
tetrandrine
approach
involves
increasing
concentration
carriers
movement
into
through
Drug Delivery,
Journal Year:
2023,
Volume and Issue:
30(1)
Published: June 2, 2023
Traditional
ophthalmic
drugs,
such
as
eye
drops,
gels
and
ointments,
are
accompanied
by
many
problems,
including
low
bioavailability
potential
drug
side
effects.
Innovative
delivery
systems
have
been
proposed
to
overcome
the
limitations
associated
with
traditional
formulations.
Recently,
contact
lens-based
gained
popularity
owing
their
advantages
of
sustained
delivery,
prolonged
retention,
improved
bioavailability,
few
Various
methods
successfully
applied
drug-loaded
lenses
release
time,
chemical
crosslinking,
material
embedding,
molecular
imprinting,
colloidal
nanoparticles,
vitamin
E
modification,
polymer
film/coating,
ion
ligand
polymerization
systems,
supercritical
fluid
technology.
Contact
play
an
important
role
in
treatment
multifarious
diseases.
This
review
discusses
latest
developments
for
diseases,
preparation
methods,
application
diseases
future
prospects.
Sensors and Actuators A Physical,
Journal Year:
2024,
Volume and Issue:
376, P. 115617 - 115617
Published: July 2, 2024
Contact
lenses
are
emerging
as
a
promising
platform
for
non-invasive
biosensing
of
various
biomarkers
in
tear
fluid.
This
review
covers
recent
advances
developing
contact
lens-based
biosensors
detecting
glucose,
lactate,
intraocular
pressure,
matrix
metalloproteinases,
and
cancer
biomarkers.
Photonic
crystal-based
colorimetric
sensors
exploiting
the
diffraction
visible
light
have
shown
great
potential
continuous
monitoring
glucose
levels.
Electrochemical
enzymatic
integrated
into
also
been
explored
lactate
glucose.
Novel
sensing
approaches
based
on
microfluidics,
antiopal
photonic
structures,
cantilevers,
surface-enhanced
Raman
spectroscopy
substrates
enabled
measurement
inflammatory
like
MMP-9,
exosomes
offer
unique
advantages
being
non-invasive,
providing
direct
sample
interface,
enabling
monitoring,
integrating
multiple
modalities.
However,
challenges
related
to
enzyme
stability,
calibration,
manufacturing
scalability,
sterilization,
regulatory
approval
need
be
addressed
before
widespread
clinical
implementation.
Overall,
this
multidisciplinary
field
combining
with
advanced
technologies
holds
immense
transforming
healthcare
through
predictive,
preventive,
personalized
ocular
systemic
conditions.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Ocular
injury
and
infection
are
significant
causes
of
vision
impairment
blindness
globally.
Effective
treatment
is,
however,
challenging
due
to
the
physical
barrier
cornea,
which
restricts
drug
penetration
in
eye,
as
well
presence
eye
that
necessitates
continuous
delivery
growth
factors
on
ocular
surface
for
cornea
healing.
Here,
we
introduce
a
transformative
wearable
corneal
microneedle
(MN)
patch
designed
efficient
therapy
infection.
The
MN
comprises
water-soluble
tips
encapsulate
antibacterial
nanoparticles
(NPs),
along
with
backing
layer
contains
epidermal
factor
(EGF).
Upon
insertion
into
dissolve
swiftly
within
stroma,
resulting
release
antimicrobial
NPs
efficiently
eradicate
bacteria.
Meanwhile,
residual
undergoes
rapid
situ
transformation
upon
contact
mildly
acidic
fluid
from
infected
edema,
converting
lens
conforms
eye's
surface,
facilitates
sustained
EGF
over
8
h
promote
Benefiting
these
features,
demonstrates
superior
efficacy
treating
injuries
infections
vivo,
offering
promising
therapeutic
strategy
manage
diseases.
