Designing advanced hydrogel inks with direct ink writing based 3D printability for engineered biostructures

European Polymer Journal, Journal Year: 2024, Volume and Issue: 205, P. 112736 - 112736

Published: Jan. 4, 2024

Language: Английский

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Recent advances in 3D bioprinted polysaccharide hydrogels for biomedical applications: A comprehensive review

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122845 - 122845

Published: Oct. 17, 2024

Polysaccharide hydrogels, which can mimic the natural extracellular matrix and possess appealing physicochemical biological characteristics, have emerged as significant bioinks for 3D bioprinting. They are highly promising applications in tissue engineering regenerative medicine because of their ability to enhance cell adhesion, proliferation, differentiation a manner akin cellular environment. This review comprehensively examines fabrication methods, polysaccharide hydrogel-driven bioprinting, underscoring its potential engineering, drug delivery, medicine. To contribute pertinent knowledge future research this field, critically key aspects, including chemistry carbohydrates, manufacturing techniques, formulation bioinks, characterization polysaccharide-based hydrogels. Furthermore, explores primary advancements 3D-printed encompassing delivery systems with controlled release kinetics targeted therapy, along tissue-engineered constructs bone, cartilage, skin, vascular regeneration. The use these bioprinted hydrogels innovative fields, disease modeling screening, is also addressed. Despite notable progress, challenges, modulating properties polysaccharides, enhancing bioink printability mechanical properties, achieving long-term vivo stability, been highlighted.

Language: Английский

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Synthesis and characterization of SiO2 nanoparticles reinforced 3D printable gelatin/PVA/guar gum/ hydroxypropyl methylcellulose-based biocomposite hydrogel

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 218, P. 118977 - 118977

Published: June 14, 2024

Language: Английский

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Evaluation of the printability of agar and hydroxypropyl methylcellulose gels as gummy formulations: Insights from rheological properties

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 654, P. 123937 - 123937

Published: Feb. 23, 2024

The trial-and-error method currently used to create formulations with excellent printability demands considerable time and resources, primarily due the increasing number of variables involved. Rheology serves as a relatively rapid highly beneficial for assessing materials evaluating their effectiveness 3D constructs. However, data obtained can be overwhelming, especially users lacking experience in this field. This study examined rheological properties agar, hydroxypropyl methylcellulose, model drug caffeine, alongside exploring gummy formulations. gels' were characterized using oscillatory rotational experiments. correlation between these was established, three clusters formed based on samples principal component analysis. Furthermore, predicted sample's property that correlated most printability, phase angle δ, regression models resulted an accuracy over 80%. Although relationships merit confirmation later studies, suggests quantitative definition relationship one development destined extrusion printing.

Language: Английский

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From conception to consumption: Applications of semi-solid extrusion 3D printing in oral drug delivery

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 674, P. 125436 - 125436

Published: March 15, 2025

Language: Английский

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Hydrogel-Based Inks for Extrusion 3D Printing: A Rheological Viewpoint

Current Opinion in Colloid & Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 101918 - 101918

Published: March 1, 2025

Language: Английский

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Nanofibrillated cellulose/gellan gum hydrogel-based bioinks for 3D bioprinting of skin cells

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 229, P. 849 - 860

Published: Dec. 24, 2022

Language: Английский

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Properties and Printability of the Synthesized Hydrogel Based on GelMA

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2121 - 2121

Published: Jan. 20, 2023

Gelatin methacryloyl (GelMA) has recently attracted increasing attention. Unlike other hydrogels, it allows for the adjustment of mechanical properties using such factors as degree functionalization, concentration, and photocrosslinking parameters. In this study, GelMA with a high substitution (82.75 ± 7.09%) was synthesized, its suitability extrusion printing, cytocompatibility, biocompatibility studied. Satisfactory printing quality demonstrated 15% concentration hydrogel. The functionalization led to decrease in ability human adipose-derived stem cells (ADSCs) adhere surface. During first 3 days after sowing, proliferation observed. Degradation animals subcutaneous implantation slowed down.

Language: Английский

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Bioprinting: A focus on improving bioink printability and cell performance based on different process parameters

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 640, P. 123020 - 123020

Published: May 4, 2023

Language: Английский

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Hydrogel Bioinks of Alginate and Curcumin-Loaded Cellulose Ester-Based Particles for the Biofabrication of Drug-Releasing Living Tissue Analogs

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(34), P. 40898 - 40912

Published: Aug. 16, 2023

3D bioprinting is a versatile technique that allows the fabrication of living tissue analogs through layer-by-layer deposition cell-laden biomaterials, viz. bioinks. In this work, composite alginate hydrogel-based bioinks reinforced with curcumin-loaded particles cellulose esters (CEpCUR) and laden human keratinocytes (HaCaT) are developed. The addition CEpCUR particles, sizes 740 ± 147 nm, improves rheological properties inks, increasing their shear stress viscosity, while preserving recovery rate mechanical viscoelastic resulting fully cross-linked hydrogels. Moreover, presence these reduces degradation hydrogels from 26.3 0.8% (ALG) to 18.7 1.3% (ALG:CEpCUR_10%) after 3 days in culture medium. structures printed ALG:CEpCUR inks reveal increased printing definition ability release curcumin (with nearly 70% cumulative 24 h PBS). After being HaCaT cells (1.2 × 106 mL-1), can be successfully bioprinted, obtained constructs show good dimensional stability high cell viabilities at 7 post-bioprinting (nearly 90%), confirming great potential for application fields like wound healing.

Language: Английский

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