Comparing continuous micromixing and extrusion downsizing for PEGylated nanoliposomes remotely loaded with doxorubicin or the steroid pro-drug methylprednisolone hemisuccinate

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113707 - 113707

Published: April 1, 2025

Language: Английский

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Bottom-up development of lipid-based synthetic cells for practical applications

Trends in biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Microfluidic-Assisted ZIF-Silk-Polydopamine Nanoparticles as Promising Drug Carriers for Breast Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1811 - 1811

Published: June 24, 2023

Metal–organic frameworks (MOFs) are heralded as potential nanoplatforms for biomedical applications. Zeolitic imidazolate framework-8 (ZIF-8), one of the most well known MOFs, has been widely applied a drug delivery carrier cancer therapy. However, application ZIF-8 nanoparticles therapeutic agent hindered by challenge how to control release behaviour anti-cancer zinc ions cells. In this paper, we designed microfluidic-assisted core-shell modified with silk fibroin (SF) and polydopamine (PDA) sustained curcumin (CUR) tested these in vitro various human breast We report that microfluidic rapid mixing is an efficient method precisely proportion ZIF-8, SF, PDA, CUR simply adjusting total flow rates (from 1 50 mL/min) rate ratios. Owing sufficient during nanoprecipitation, our designer CUR@ZIF-SF-PDA had desired particle size 170 nm narrow distribution (PDI: 0.08), which much smaller than produced using traditional magnetic stirrer (over 1000 nm). Moreover, properly coated SF layer successfully enhanced capability reservoir ions. Meanwhile, self-etching reaction between PDA naturally induced pH-responsive level MDA-MB-231, SK-BR-3, MCF-7 cell lines, resulting high cellular uptake efficiency, cytotoxicity, cycle arrest. More importantly, biocompatibility remained low cytotoxicity on AD-293 non-cancer demonstrate prepared promising carriers controlled

Language: Английский

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Microfluidics-mediated Liposomal Nanoparticles for Cancer Therapy: Recent Developments on Advanced Devices and Technologies

Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(14), P. 1185 - 1211

Published: March 1, 2024

Abstract: Liposomes, spherical particles with phospholipid double layers, have been extensively studied over the years as a means of drug administration. Conventional manufacturing techniques like thin-film hydration and extrusion limitations in controlling liposome size distribution. Microfluidics enables superior tuning parameters during self-assembly liposomes, producing uniform populations. This review summarizes microfluidic methods for engineering including hydrodynamic flow focusing, jetting, micro mixing, emulsions. The precise control lamellarity afforded by microfluidics has advantages cancer therapy. Liposomes created through designed to encapsulate chemotherapy drugs exhibited several advantageous properties treatment. They showcase enhanced permeability retention effects, allowing them accumulate specifically tumor tissues passively. passive targeting tumors results improved delivery efficacy while reducing systemic toxicity. Promising observed pancreatic, lung, breast, ovarian models, making potential breakthrough Surface-modified antibodies or carbohydrates, also achieve active targeting. Overall, fabrication improves reproducibility scalability compared traditional maintaining loading biological efficacy. Microfluidics-engineered liposomal formulations hold significant overcome challenges nanomedicine-based

Language: Английский

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Research progress and application exploration of typical microreactor technologies for health monitoring and disease Diagnosis/Treatment

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155938 - 155938

Published: Sept. 1, 2024

Language: Английский

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