AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(8)
Published: Nov. 21, 2023
Language: Английский
ACS Omega, Journal Year: 2025, Volume and Issue: 10(1), P. 1207 - 1225
Published: Jan. 3, 2025
Manufacturing bioactive materials for drug delivery involves developing that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is optimize therapeutic efficacy reduce side effects by combining knowledge from engineering, biology, pharmacology. This study presents detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," "drug delivery" identify highlight significant advancements field. From Web of Science, 36,504 articles were analyzed, 171 selected deeper identifying key journals, countries, institutions, authors. results field's interdisciplinary nature, grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, glass, tissue engineering. Future research this area will focus on more effective precise systems using technologies like 3D printing nanotechnology enhance customization control release, aiming efficient therapies.
Language: Английский
Citations
6
Cosmetics, Journal Year: 2024, Volume and Issue: 11(1), P. 22 - 22
Published: Feb. 6, 2024
Acne vulgaris is a prevalent dermatological disorder that impacts the quality of life for millions people around world. The multifactorial nature this requires innovative and effective treatment strategies. Over time, there has been growing interest regarding use natural topical therapies, with cannabinoids emerging as promising group compounds investigation. In context acne treatment, are particular due to their anti-acne properties, namely, lipostatic, anti-inflammatory, antiproliferative, antimicrobial activities. Among these bioactive compounds, cannabidiol stands out notable derivative, exhibiting spectrum therapeutic actions. Pre-clinical clinical studies have proven its ability modulate sebum production, reduce inflammation, inhibit bacterial proliferation—all which critical components in pathogenesis dermatosis. This review provides comprehensive overview cannabinoids’ potential novel holistic approach summarizes recent developments area.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1371 - 1371
Published: Jan. 23, 2024
The highly aggressive and invasive glioblastoma (GBM) tumour is the most malignant lesion among adult-type diffuse gliomas, representing common primary brain in neuro-oncology practice of adults. With a poor overall prognosis strong resistance to treatment, this nervous system requires new innovative treatment. GBM polymorphic consisting an array stromal cells various contributing initiation, progression, treatment response. Cannabinoids possess anti-cancer potencies against glioma cell lines animal models. To improve existing cannabinoids as functionalised ligands on nanocarriers were investigated potential agents. microenvironment multifaceted resident or recruited immune cells, extracellular matrix components, tissue-resident soluble factors. accounts for substantial volume tumours. barriers with cannabinoids, such crossing blood–brain barrier psychoactive off-target side effects, can be alleviated use nanocarrier drug delivery systems improved specificity targeting pharmacological receptors signalling pathways. This review has shown presence endocannabinoid microenvironment, which used unique target specific delivery. Existing cannabinoid agents, studied previously, show via pathways associated hallmarks cancer. results provide guidance design future therapy
Language: Английский
Citations
5
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 241 - 241
Published: Feb. 7, 2024
Multiple sclerosis is the predominant autoimmune disorder affecting central nervous system in adolescents and adults. Specific treatments are categorized as disease-modifying, whereas others symptomatic to alleviate painful symptoms. Currently, no singular conventional therapy universally effective for all patients across stages of illness. Nevertheless, cannabinoids exhibit significant promise their capacity neuroprotection, anti-inflammation, immunosuppression. This review will examine traditional treatment multiple sclerosis, increasing interest using cannabis a method, its role protecting regulating immune system, commercially available therapeutic cannabinoids, emerging use nanomedicine. In conclusion, potential disease-modifying rather than merely relief. However, further research necessary unveil establish safety advancements nano-cannabinoid medicine, offering reduced toxicity fewer adverse effects, thereby maximizing benefits cannabinoids.
Language: Английский
Citations
5
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116969 - 116969
Published: June 21, 2024
Cannabidiol (CBD), a naturally occurring cyclic terpenoid found in Cannabis sativa L., is renowned for its diverse pharmacological benefits. Marketed as remedy various health issues, CBD products are utilized by patients supplementary therapy or post-treatment failure, well healthy individuals seeking promised advantages. Despite widespread use, information regarding potential adverse effects, especially genotoxic properties, limited. The present study focused on the mutagenic and activity of isolate (99.4 % content) CBD-rich L extract (63.6 vitro. Both samples were non-mutagenic, determined AMES test (OECD 471) but exhibited cytotoxicity HepG2 cells (∼IC
Language: Английский
Citations
5
AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(5)
Published: May 30, 2024
Cannabinoids, such as ∆
Language: Английский
Citations
4
Molecules, Journal Year: 2023, Volume and Issue: 28(17), P. 6434 - 6434
Published: Sept. 4, 2023
Natural and non-natural hexahydrocannabinols (HHC) were first described in 1940 by Adam late 2021 arose on the drug market United States some European countries. A background discovery, synthesis, pharmacology studies of hydrogenated saturated cannabinoids is described. This harmonized with a summary comparison cannabinoid receptor affinities various classical, hybrid, non-classical cannabinoids. discussion structure–activity relationships four different pharmacophores found scaffold added to this review. According laboratory vitro, several animal species vivo, HHC reported have broadly similar effects Δ9-tetrahydrocannabinol (Δ9-THC), main psychoactive substance cannabis, as demonstrated both vitro vivo. However, treatment not been studied humans, thus biological profile has established.
Language: Английский
Citations
10
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Abstract Intraoral delivery of active pharmaceutical ingredients (API) is an attractive approach to improve their local therapeutic efficacy or enable systemic delivery. It offers several advantages, such as high drug concentration at the intraoral target site and rapid access circulation due vascularization oral cavity, bypassing first‐pass metabolism. However, limitations need be addressed, relatively short residence time formulations applied in cavity salivation, swallowing reflex, tongue movement, well poor membrane permeability of, particular, hydrophilic drugs. Within this review, a comprehensive summary latest strategies formulation approaches field provided, focusing on those pursued by academia industry overcome challenges. An overview provided excipients that are generally recognized safe (GRAS) utilized enhance systems, mucoadhesive materials, enzyme inhibitors, permeation enhancers. Innovative dosage forms outlined, covering solid, semi‐solid, liquid systems aerosols. Future trends, including self‐emulsifying microneedles, situ bioprinting, explored, presenting new opportunities for
Language: Английский
Citations
0
Journal of Biomedical Materials Research Part A, Journal Year: 2025, Volume and Issue: 113(5)
Published: April 25, 2025
ABSTRACT Cannabidiol (CBD) holds promise for managing metabolic diseases, yet enhancing its oral bioavailability and efficacy remains challenging. To address this, we developed polymeric nanoparticles (NPs), using poly(lactic‐co‐glycolic acid) (PLGA), encapsulating CBD nanoprecipitation, aiming to create an effective CBD‐nanoformulation disorder treatment. These NPs (135–265 nm) demonstrated high encapsulation efficiency (EE% ≈ 100%) sustained release kinetics. Their therapeutic potential was evaluated in vitro syndrome model employing sodium palmitate‐induced HepG2 cells. Key assessment parameters included cell viability (MTT assay), glucose uptake, lipid accumulation (Oil Red O staining), triglycerides, cholesterol, HDL‐c levels, gene expression of regulators. Results showed IC50 9.85 μg/mL free 11.26 CBD‐loaded NPs. significantly enhanced reduced content, lowered triglycerides total increased levels compared CBD. Gene analysis indicated gluconeogenesis via downregulation PPARγ, FOXO‐1, PEPCK, G6Pase fatty acid oxidation through CPT‐1 upregulation. findings suggest that may serve as a novel strategy the management disorders, warranting further vivo studies.
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: May 22, 2025
Language: Английский
Citations
0