The
number
of
people
affected
by
eye
conditions
is
growing
every
year,
due
to
the
popularity
electronic
devices
and
an
aging
population.
In
world
medicine,
accomplishing
medication
administration
has
always
been
a
difficult
task.
Despite
fact
that
there
are
many
drops
on
market,
most
them
have
important
limitations
quick
clearance
mechanisms
ocular
barriers.
One
solution
with
tremendous
potential
contact
lens
used
as
delivery
vehicle
bypass
this
constraint.
Therapeutic
lenses
for
attracted
lot
attention
because
they
improve
bioavailability,
patient
compliance,
reduce
side
effects.
However,
it
essential
not
compromise
features
such
water
content,
optical
transparency,
modulus
in
order
target
successful
vitro
vivo
sustained
drug
profile
from
impregnated
lenses.
Aside
difficulties
like
stability
burst
release,
changing
physical
chemical
properties
caused
therapeutic
or
non-therapeutic
components
can
limit
commercialization
pharmaceutical-loaded
Research
progressed
towards
bioinspired
techniques
smart
materials
efficacy
drug-eluting
method
uses
polymeric
biocompatibility,
specialized
molecule
recognition
technique
called
molecular
imprinting,
stimuli-responsive
system
biocompatibility
support
This
review
encompasses
strategies
material
design,
manufacturing
impregnation
under
current
auspices
ophthalmic
therapies
projects
outlook
onto
future
opportunities
field
management
means
active
principles-eluting
lens.
Smart Molecules,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: March 1, 2024
Abstract
This
comprehensive
review
delves
into
a
unique
intersection
of
hydrogels
as
smart
molecules
and
their
transformative
applications
in
ophthalmology.
Beginning
with
the
foundational
definition,
properties,
classification
hydrogels,
explores
synthesis
responsive
capabilities.
Specific
examined
encompass
topical
drug
delivery,
contact
lenses,
intravitreal
ocular
adhesives,
vitreous
substitutes,
cell‐based
therapy.
A
methodical
analysis,
including
an
overview
relevant
structures
comparative
evaluation
hydrogel‐based
solutions
against
traditional
treatments,
is
conducted.
Additionally,
potential
constraints,
translation
challenges,
knowledge
gaps,
research
areas
are
identified.
Our
approach,
guided
by
extensive
literature
from
2017
to
2023,
illuminates
unprecedented
opportunities
offered
along
pinpointing
for
further
inquiry
facilitate
transition
clinical
practice.
Colloids and Interface Science Communications,
Journal Year:
2024,
Volume and Issue:
61, P. 100794 - 100794
Published: July 1, 2024
Fungal
keratitis
is
a
globally
blinding
eye
disease
caused
by
fungi,
with
more
than
1.05
million
cases
diagnosed
annually,
mainly
in
Asia.
It
the
most
common
form
of
infectious
keratitis,
accounting
for
approximately
40–50%
microbial
cases.
The
difficult
to
treat
and
prognosis
often
poor.
Conventional
antimicrobial
therapies,
which
are
mainstay
treatment,
face
problems
off-target
toxicity,
low
bioavailability,
drug-resistant
fungi.
In
recent
years,
novel
drug
delivery
systems
have
emerged
as
promising
alternative.
These
improve
stability,
extend
residence
time,
control
release,
target
specific
tissues
cells,
reduce
toxic
side
effects.
Nanoparticle-based
particularly
compelling.
aim
this
paper
elucidate
mechanisms
advances
nanoparticle-based
antifungal
therapy
provide
new
perspectives
on
treatment
fungal
keratitis.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Nov. 2, 2023
Abstract
Despite
the
existence
of
numerous
eye
drops
in
market,
most
them
are
not
sufficiently
effective
because
quick
clearance
and
barriers
within
eye.
To
increase
delivery
drugs
to
eye,
various
new
formulations
have
been
explored
recent
decades.
These
aim
enhance
drug
retention
penetration,
while
enabling
sustained
release
over
extended
periods.
One
such
innovative
approach
is
utilization
contact
lenses,
which
were
originally
designed
for
cosmetic
purposes
vision
correction.
Contact
lenses
appeared
as
a
promising
formulation
ocular
delivery,
they
can
bioavailability
diminish
unwanted
side
effects.
They
specifically
appropriate
treating
chronic
conditions,
making
an
area
interest
researchers
field
ophthalmology.
This
review
outlines
potential
nanomaterial-laden
diagnosis
treatment
glaucoma.
It
classifies
therapeutic
approaches
based
on
nanomaterial
type,
summarizes
diagnostic
advances,
discusses
improvement
properties,
covers
marketing
perspectives,
acknowledges
challenges
these
glaucoma
management.
Biointerphases,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 1, 2025
The
special
structure
of
eyes
and
the
existence
various
physiological
barriers
make
ocular
drug
delivery
one
most
difficult
problems
in
pharmaceutical
field.
Considering
patient
compliance,
local
administration
remains
preferred
method
anterior
part
eyes.
However,
suffers
from
poor
bioavailability,
need
for
frequent
administration,
systemic
toxicity.
Administration
posterior
eye
is
more
difficult,
intravitreal
injection
often
used.
But
faces
compliance
likely
side
effects
after
multiple
injections.
development
nanocarrier
technology
provides
an
effective
way
to
solve
these
problems.
Among
them,
liposomes,
as
widely
used
carrier
clinical
application,
have
characteristics
amphiphilic
nanostructure,
easy
surface
modification,
extended
release
time,
good
biocompatibility,
etc.
liposomes
are
expected
overcome
obstacles
effectively
deliver
drugs
target
site
improve
bioavailability.
This
review
summarized
controllable
properties
well
application
research
progress
diseases.
In
addition,
we
routes
contained
eyes,
prospects
treatment
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(5), P. 4580 - 4587
Published: Jan. 29, 2025
The
uptake
and
release
of
target
molecules
were
studied
in
hydrogels
as
a
function
time
over
month
to
determine
what,
if
any,
deviation
exists
these
properties.
Through
the
use
spectroscopic
techniques
such
FT-IR
UV–vis–NIR
combination
with
drug
kinetics
swelling
studies,
both
effect
imprinting
could
be
substantially
analyzed
for
hydrogels.
Molecular
provides
significant
advantage
nonimprinted
hydrogel
samples
through
sustainment
first-order
profile
throughout
without
deviations
releasable
concentration,
while
struggle
their
capability
consistently
load-cycled.
Changes
between
imprinted
are
not
evidenced
chemical
deviations;
rather,
they
attributable
functionality
differences
mechanisms
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Consistent
corneal
epithelial
injury
would
cause
chronic
inflammation,
neovascularization,
and
even
scarring,
resulting
in
vision
loss.
Rapid
repair
is
crucial
for
treatment,
within
which
the
use
of
therapeutic
contact
lenses
presents
great
promise.
A
challenge
how
to
achieve
rapid
severely
deficient
epithelium
regulation
oxidative
stress
environment
simultaneously.
Herein,
a
"bioactive"
lens,
mimicking
layered
helical
structure
native
cornea,
designed
based
on
assembly
cellulose
nanocrystals
(CNCs)
inside
poly(hydroxyethyl
methacrylate)
(PHEMA)
with
CeOx
formed
CNCs'
surface
(CeOx/CNC@CNC-PHEMA).
The
obtained
CeOx/CNC@CNC-PHEMA
hydrogel
possesses
chiral
that
regulates
microenvironment,
nanoscaled
(CeOx/CNC)
acts
as
reactive
oxygen
species
(ROS)
scavenger
triggers
lens
repair.
This
meets
conditions
including
high
degree
transparency,
excellent
mechanical
properties,
ROS-scavenging
efficacy,
significant
enhancement
biocompatibility.
Importantly,
adhesion
proliferation
human
cells
hydrogels
are
successful.
An
vitro
damage
model
vivo
animal
experiments
were
conducted,
results
revealed
realized
migration
antioxidant,
anti-inflammatory,
antineovascular
effects,
achieving
modulation
ocular
evidencing
property
lens.
biotopological
biomimetic
architecture
has
provided
rational
strategy
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(3)
Published: March 1, 2025
ABSTRACT
Moxifloxacin
(MOX)
was
loaded
into
commercial
contact
lenses
(CLs)
via
supercritical
carbon
dioxide
(ScCO
2
)
to
attain
MOX‐impregnated
CL
for
keratitis
treatment.
This
study
aimed
investigate
Pseudomonas
treatment
with
compared
the
traditional
eyedrop
administration.
MOX
impregnation
accomplished
employing
optimum
parameters
of
2.5
h
drug
exposure
time,
25
MPa
pressure,
and
313
K
ScCO
conditions
using
ethanol
co‐solvent
rendering
sustainable
delivery,
up
7
days
at
effective
dosage
formulation.
The
found
be
safe
no
significant
toxicity
on
fibroblast
cells
after
5
time.
Bacterial
viability
in
vivo
rabbit
eyes
significantly
decreased
10
from
9
CFU/cornea
treatment,
almost
similar
exhaustive
conventional
0.5%
eye
drop
treatments.
revealed
conjunctival
hyperemia,
edema,
or
secretion
all
relevant
group,
transparent
cornea
focus
obtained
two
(
n
=
6).
normal
histological
structure
seen
healthy
eyes.
Moreover,
polymorphonuclear
cell
infiltration
observed
without
any
a
few
groups
treated
eyedrops
CL.
Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(11), P. 1571 - 1571
Published: Nov. 3, 2023
In
the
advent
of
an
increasingly
aging
population
and
due
to
popularity
electronic
devices,
ocular
conditions
have
become
more
prevalent.
world
medicine,
accomplishing
eye
medication
administration
has
always
been
a
difficult
task.
Despite
fact
that
there
are
many
commercial
drops,
most
them
important
limitations,
quick
clearance
mechanisms
barrers.
One
solution
with
tremendous
potential
is
contact
lens
used
as
delivery
vehicle
bypass
this
constraint.
Therapeutic
lenses
for
attracted
lot
attention
because
they
improve
bioavailability
patient
compliance,
both
minimal
side
effects.
However,
it
essential
not
compromise
features
such
water
content,
optical
transparency,
modulus
attain
positive
in
vitro
vivo
outcomes
respect
sustained
drug
profile
from
impregnated
lenses.
Aside
difficulties
like
stability
burst
release,
changing
physico-chemical
caused
by
therapeutic
or
non-therapeutic
components
can
limit
commercialization
pharmaceutical-loaded
Research
progressed
towards
bioinspired
techniques
smart
materials,
efficacy
drug-eluting
The
method
uses
polymeric
specialized
molecule-recognition
technique
called
molecular
imprinting
stimuli-responsive
system
biocompatibility
support
This
review
encompasses
strategies
material
design,
manufacturing
impregnation
under
current
auspices
ophthalmic
therapies
projects
outlook
onto
future
opportunities
field
condition
management
means
active
principle-eluting
lens.
Colloids and Surfaces A Physicochemical and Engineering Aspects,
Journal Year:
2024,
Volume and Issue:
688, P. 133550 - 133550
Published: Feb. 23, 2024
Loading
hydrophobic
drugs,
such
as
cyclosporine,
into
contact
lenses
for
dry
eye
treatment
is
challenging
due
to
low
drug
uptake
during
soaking
and
alterations
in
critical
lens
properties,
including
wettability,
water
content,
optical
transmission.
This
study
aimed
investigate
the
role
of
micelle
dynamics
enhancing
cyclosporine
loading
hyaluronic
acid
(HA)-contact
while
improving
their
properties.
The
findings
indicate
that
Pluronic®
F127
(342
nm)
Tween®
80
(296
micelles
could
encapsulate
within
core,
with
demonstrating
superior
surface
tension
on
Langmuir-Blodgett
trough
compared
80.
cyclosporine-loaded
(13.43–20.92
µg)
was
higher
without
(CY-CL
=
8.80
µg).
Moreover,
improved
lens's
angle
(wettability),
equilibrium
transmission
micelles.
vitro
test
showed
sustained
release
from
over
120
h
or
96
using
Pluronic®-micelles
80-micelles,
respectively.
In
animal
study,
0.05%
w/v
F127-CL
0.0015%
Tween
80-CL
an
initial
2.54
µg/ml
3.59
µg/ml,
respectively,
profile
extending
48
h.
Wear
micelle-laden
resulted
lower
levels
IL-6
drops.
conclusion,
demonstrated
greater
stability,
release,
outcomes
These
suggest
potential
micelles-laden
a
promising
alternative
drops
management.
