Advances in Therapeutic Contact Lenses for Different Ocular Condition Management DOI Open Access
Mariana Ioniță,

George Mihai Vlăsceanu,

Georgian Alin Toader

et al.

Published: Oct. 1, 2023

The number of people affected by eye conditions is growing every year, due to the popularity electronic devices and an aging population. In world medicine, accomplishing medication administration has always been a difficult task. Despite fact that there are many drops on market, most them have important limitations quick clearance mechanisms ocular barriers. One solution with tremendous potential contact lens used as delivery vehicle bypass this constraint. Therapeutic lenses for attracted lot attention because they improve bioavailability, patient compliance, reduce side effects. However, it essential not compromise features such water content, optical transparency, modulus in order target successful vitro vivo sustained drug profile from impregnated lenses. Aside difficulties like stability burst release, changing physical chemical properties caused therapeutic or non-therapeutic components can limit commercialization pharmaceutical-loaded Research progressed towards bioinspired techniques smart materials efficacy drug-eluting method uses polymeric biocompatibility, specialized molecule recognition technique called molecular imprinting, stimuli-responsive system biocompatibility support This review encompasses strategies material design, manufacturing impregnation under current auspices ophthalmic therapies projects outlook onto future opportunities field management means active principles-eluting lens.

Language: Английский

Drug Delivery in PROSE Device as Alternative to Frequent Drop Administration in Severe Ocular Surface Disease DOI

Yandong Bian,

Deborah S. Jacobs

Eye & Contact Lens Science & Clinical Practice, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract: The design of the prosthetic replacement ocular surface ecosystem (PROSE) device allows it to serve as a novel drug delivery system. In this article, we describe off-label administration amphotericin B and cenegermin by instillation in PROSE reservoir for treatment Candida keratitis setting persistent epithelial defect.

Language: Английский

Citations

0
Advances in Therapeutic Contact Lenses for Different Ocular Condition Management DOI Open Access
Mariana Ioniță,

George Mihai Vlăsceanu,

Georgian Alin Toader

et al.

Published: Oct. 1, 2023

The number of people affected by eye conditions is growing every year, due to the popularity electronic devices and an aging population. In world medicine, accomplishing medication administration has always been a difficult task. Despite fact that there are many drops on market, most them have important limitations quick clearance mechanisms ocular barriers. One solution with tremendous potential contact lens used as delivery vehicle bypass this constraint. Therapeutic lenses for attracted lot attention because they improve bioavailability, patient compliance, reduce side effects. However, it essential not compromise features such water content, optical transparency, modulus in order target successful vitro vivo sustained drug profile from impregnated lenses. Aside difficulties like stability burst release, changing physical chemical properties caused therapeutic or non-therapeutic components can limit commercialization pharmaceutical-loaded Research progressed towards bioinspired techniques smart materials efficacy drug-eluting method uses polymeric biocompatibility, specialized molecule recognition technique called molecular imprinting, stimuli-responsive system biocompatibility support This review encompasses strategies material design, manufacturing impregnation under current auspices ophthalmic therapies projects outlook onto future opportunities field management means active principles-eluting lens.

Language: Английский

Citations

1