MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings

Small, Journal Year: 2024, Volume and Issue: 20(30)

Published: March 7, 2024

Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials

Language: Английский

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Electrospun nylon 6/hyaluronic acid/chitosan bioactive nanofibrous composite as a potential antibacterial wound dressing

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2024, Volume and Issue: 112(1)

Published: Jan. 1, 2024

Abstract Hyaluronic acid (HA) and chitosan (CS), as natural biomaterials, display excellent biocompatibility stimulate the growth proliferation of fibroblasts. Furthermore, nylon 6 (N6) is a low‐cost polymer with good compatibility human tissues high mechanical stability. In this study, HA CS were applied to modify N6 nanofibrous mat (N6/HA/CS) for potential wound dressing. N6/HA/CS composite mats developed using simple one‐step electrospinning technique at different concentrations 1, 2, 3 wt%. The results demonstrated that incorporating into resulted in increased hydrophilicity, well favorable physical properties. addition, minimum inhibitory concentration (MIC) optical density techniques used determine antibacterial properties mats, composites could markedly inhibit Gram‐positive bacteria Staphylococcus aureus Gram‐negative Escherichia coli . Because its superior properties, substantial antimicrobial effects, hydrophilic surface, 2 wt% (N6/HA/CS2) was chosen most suitable mat. swelling, porosity, gel content, vitro degradation studies imply N6/HA/CS2 has proper moisture retention biodegradability. discovered be nontoxic L929 fibroblast cells even improve cell proliferation. Based on findings, research offers rapid method creating material utilized prospective dressings clinical environments.

Language: Английский

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Development of a labeled-free and labeled electrochemical aptasensor for the detection of cancer antigen 125 by using magnetic g-C3N4/MoS2 nanocomposite

Sensors and Actuators Reports, Journal Year: 2024, Volume and Issue: 7, P. 100195 - 100195

Published: April 24, 2024

Efficient and timely detection of cancer biomarkers is pivotal for enhancing treatment outcomes mitigating patient mortality. This study addresses the pressing need a swift, accurate, non-invasive method to identify antigen 125 (CA125), vital biomarker in ovarian cancer. Leveraging growing prominence nano-biosensors their high selectivity sensitivity, we present development characterization an innovative electrochemical nano-biosensor. The sensor, featuring aptamer strands immobilized on glassy carbon electrode modified with graphitic nitrides, molybdenum disulfide, magnetic nanoparticles (g-C3N4/MoS2/Fe3O4), demonstrates superior sensitivity accuracy CA125 detection. Utilizing methylene blue labeled ferrocyanide label-free detection, our aptasensor achieves low limit (LOD) at 0.202 U.mL−1 0.215 U.mL−1, respectively, broad range from 2 10 U.mL−1. exhibits pronounced affinity CA125, demonstrating enhanced stability compared other biomolecules. Crucially, evaluation both normal serum samples underscores aptasensor's remarkable performance. These findings not only establish robust foundation future research diagnosis but also highlight potential clinical impact nano-biosensor advancing early methodologies.

Language: Английский

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Aptamer-enabled electrochemical bioplatform utilizing surface-modified g-C3N4/MoS2/PANI nanocomposite for detection of CA125 biomarker

Sensing and Bio-Sensing Research, Journal Year: 2024, Volume and Issue: 45, P. 100669 - 100669

Published: June 28, 2024

Detecting ovarian cancer at an early stage is crucial for enhancing patient outcomes, underscoring the demand efficient and non-invasive detection method. Cancer antigen 125 (CA125) a vital biomarker in detection, there pressing to develop quick, sensitive, simple Nanobiosensors are increasingly being used by scientists due their high selectivity sensitivity, allowing swift precise of wide range biomarkers. This study aimed design fabricate electrochemical nanobiosensor that could accurately selectively detect CA125. The employed graphitic carbon nitrides, molybdenum disulfide, polyaniline (g-C3N4/MoS2/PANI) stabilize aptamer strands on modified glassy electrode. aptasensor was perform labeled CA125, utilizing methylene blue label-free ferrocyanide methods. Ferrocyanide limits were determined be 0.196 U.mL−1 blue, with linear 2–10 detection. results showed electrode exhibited towards CA125 superior stability compared other biomolecules. also displayed impressive performance when analyzing serum patients healthy people. These findings hold significant promise future investigation diagnosis. novel may aid management cancer, ultimately leading better outcomes.

Language: Английский

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Potential of Curcumin in the Management of Skin Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3617 - 3617

Published: March 23, 2024

Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal preventing treating skin inflammation, premature ageing, psoriasis, acne. Additionally, exhibits antiviral, antimutagenic, antifungal effects. provides protection against damage caused by prolonged exposure UVB radiation. It reduces wound healing times improves collagen deposition. Moreover, increases fibroblast vascular density in wounds. review summarizes available information on therapeutic effect curcumin diseases. The results suggest that may be an inexpensive, well-tolerated, effective agent However, larger clinical trials are needed confirm these observations limitations vivo use, such as low bioavailability after oral administration metabolism.

Language: Английский

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The Horizons of Medical Mineralogy: Structure-Bioactivity Relationship and Biomedical Applications of Halloysite Nanoclay

ACS Nano, Journal Year: 2024, Volume and Issue: 18(31), P. 20001 - 20026

Published: July 17, 2024

Medical mineralogy explores the interactions between natural minerals and living organisms such as cells, tissues, organs develops therapeutic diagnostic applications in drug delivery, medical devices, healthcare materials. Many (especially clays) have been recognized for pharmacological activities potential. Halloysite clay (Chinese medicine name: Chishizhi), manifested one-dimensional aluminum silicate nanotubes (halloysite nanotubes, HNTs), has gained hemostasis, wound repair, gastrointestinal diseases, tissue engineering, detection sensing, cosmetics, daily chemicals formulations. Various biomedical of HNTs are derived from hollow tubular structures, high mechanical strength, good biocompatibility, bioactivity, unique surface characteristics. This nanomaterial is safe, abundantly available, may be processed with environmentally safe green chemistry methods. review describes structure physicochemical properties relative to bioactivity. We discuss area, porosity defects, hydrophilicity, heterogeneity charge external internal surfaces, well biosafety. The paper provides comprehensive guidance development this tubule nanoclay its advanced clinical diagnosis therapy.

Language: Английский

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Enhancing H. pylori detection: ultrasensitive electrochemical aptasensor with Au-doped CQDs and polythiophene conjugation

Journal of Applied Electrochemistry, Journal Year: 2024, Volume and Issue: 54(8), P. 1887 - 1900

Published: Feb. 16, 2024

Language: Английский

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Halloysite nanotube-polymer nanocomposites: A review on fabrication and biomedical applications

Journal of Manufacturing Processes, Journal Year: 2024, Volume and Issue: 118, P. 76 - 88

Published: March 18, 2024

Polymer nanocomposites, which incorporate nanomaterials into a polymer matrix, are known for their exceptional material properties attributed to strong interfacial interactions between different components. Halloysite nanotubes (Hal) that have been characterized by unique tubular structure, high aspect ratio, excellent mechanical strength, and low toxicity garnered scientific attention, exploring potential as reinforcing polymers with enhanced biocompatibility in the biomedical field. This review explores fabrication techniques employed develop Hal-based nanocomposites examines impacts of incorporating Hal matrices, mainly focusing on its effects processes enhancements diverse applications. Common techniques, including solution mixing, melt processing, situ polymerization, electrospinning, electrophoretic deposition, applications, each technique having own set advantages limitations. Consequently, these facilitate development offering improved structural functional previously unachievable through conventional polymers. Such advancements hold promise drug delivery, tissue engineering, wound healing, packaging

Language: Английский

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Sustainable wastewater treatment: LDH@Fe3O4-Ag as a promising photocatalyst for tetracycline degradation

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 396, P. 124005 - 124005

Published: Jan. 12, 2024

Language: Английский

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A bi‐functional nanofibrous composite membrane for wound healing applications

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(8)

Published: May 15, 2024

Various wound dressings have been developed so far for healing, but most of them are ineffective in properly reestablishing the skin's structure, which increases infection risks and dehydration. Electrospun membranes particularly interesting dressing applications because they mimic extracellular matrix healthy skin. In this study, a potential healing platform capable inducing synergistic antibacterial antioxidation activities was by incorporating bio-active rosmarinic acid-hydroxyapatite hybrid (HAP-RA) with different contents (0.5, 1, 1.5 wt.%) into electrospun polyamide 6 (PA6) nanofibers. Then, polyethylene glycol (PEG) introduced to nanofibrous composite improve biocompatibility biodegradability dressing. The results indicated that hydrophilicity, water uptake, biodegradability, mechanical properties obtained PA6/PEG/HAP-RA enhanced at 1 wt.% HAP-RA. had excellent activity. samples assessed vitro. MTT assay performed on L929 cell line confirmed positive effects scaffold viability proliferation. According results, showed desirable physiochemical biological besides antioxidative capabilities, making it promising candidate further studies applications.

Language: Английский

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