“Development, optimization, and characterization of Eudragit-based nanoparticles for Dasatinib delivery” DOI

G Hemanth,

Anasuya Patil,

Hariprasad MG

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Nov. 19, 2024

This study focused on developing and evaluating dasatinib-loaded nanoparticles (DST-NPs) using Eudragit L100 as a polymer matrix for enhanced breast cancer treatment. The optimized formulation exhibited particle size of 202.1 ± 5.7 nm, zeta potential −18 1.01 mV, an entrapment efficiency 93.11 0.2%. In-vitro release studies demonstrated sustained drug from DST-NPs, following Fickian diffusion. Pharmacokinetic in rats revealed higher Cmax AUC0-t DST-NPs compared to pure DST, indicating improved bioavailability. Tissue distribution showed targeting with concentrations the liver spleen. In vivo efficacy DMBA-induced mammary carcinoma model that significantly reduced tumor volume, maintained stable body weight, survival rates DST. Hematologic analysis indicated favorable blood profile histopathological examinations confirmed restoration normal gland architecture. MTT assays cytotoxicity against MCF-7, MDA-MB231, 4T1 cell lines, lower IC50 values than Stability their properties over six months at various storage conditions. These findings highlight effective nanocarrier system therapy.

Language: Английский

Advances in chitosan-based blends as potential drug delivery systems: A review DOI
Mohamed J. Saadh, Chou‐Yi Hsu, Mohammed Ahmed Mustafa

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132916 - 132916

Published: June 5, 2024

Language: Английский

Citations

19
Fabrication and characterization of teriflunomide-loaded chondroitin sulfate hybridized zein nanoparticles for the management of triple negative breast cancer DOI
Naveen Rajana,

Lakshmi Tulasi Naraharisetti,

Nalla Usha Kumari

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140316 - 140316

Published: Jan. 1, 2025

Language: Английский

Citations

1
Investigation of a Palbociclib and Naringin Co-Amorphous System to Ameliorate Anticancer Potential: Insights on In Silico Modeling, Physicochemical Characterization, Ex Vivo Permeation, and In Vitro Efficacy DOI

Tanmoy Kanp,

Anish Dhuri,

Mayur Aalhate

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Palbociclib (PCB), categorized as a BCS class II drug, is characterized by low aqueous solubility. The drug's limited solubility and poor dissolution rate pose significant challenges, potentially affecting its absorption overall therapeutic efficacy. Co-amorphous (CAM) systems have been extensively investigated potential solution to overcome the issue of water in numerous active pharmaceutical ingredients. This research study hypothesized that coamorphization process involving compounds PCB naringin (NG) would lead an increase PCB. Additionally, it was proposed this also enhance anticancer impact since NG recognized for pharmacological on breast cancer cells. In silico studies, revealed could interact with via hydrogen bonding. Furthermore, prepared CAM (PCB-NG-CAM) system using PXRD, DSC, FTIR, Raman spectroscopy, solid-state 13C nuclear magnetic resonance, SEM. PCB-NG-CAM exhibited solubility, rate, intestinal permeation compared crystalline excellent physical stability at 40 °C/75% RH up 3 months. addition, showed superior vitro efficacy MDA-MB-231 triple-negative cell lines. resulted 2.24 times higher apoptosis 1.6 greater ROS production than free inhibitory effect migration alterations MMP more pronounced cells treated PCB-NG-CAM. Therefore, indicated has significantly improve oral administration,

Language: Английский

Citations

0
Oral linalool-based nanoemulsion of acalabrutinib for ameliorating its oral bioavailability and in vitro anticancer potential in T lymphoblast cell lines DOI

Arti Shettiwar,

Ujala Gupta,

Essha Chatterjee

et al.

Colloid & Polymer Science, Journal Year: 2024, Volume and Issue: 302(10), P. 1491 - 1511

Published: July 4, 2024

Language: Английский

Citations

3
Manifesting the Dasatinib-gallic acid co-amorphous system to augment anticancer potential: Physicochemical characterization, in silico molecular simulation, ex vivo permeability, and in vitro efficacy DOI

Tanmoy Kanp,

Anish Dhuri,

Mayur Aalhate

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 665, P. 124672 - 124672

Published: Sept. 7, 2024

Language: Английский

Citations

3
Exploration of Enalapril-Lacidipine Co-Amorphous System with Superior Dissolution, In vivo Absorption and Physical Stability via Incorporated into Mesoporous Silica DOI Creative Commons
Yuhan Guo, Hanyu Wang, Qiang Zhu

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 207, P. 107033 - 107033

Published: Feb. 5, 2025

In the present study, enalapril (ENP) was taking as a potential co-former to fabricate co-amorphous system with lacidipine (LCDP). The ENP/LCDP firstly prepared or without mesoporous SiO2 and characterized by DSC, XRD SEM technologies. molecular interactions were evaluated FTIR spectrums. Furthermore, dissolution pharmacokinetics behavior of various formulations also carried out. It demonstrated that completely co-amorphization obtained at 2:1 molar ratio intermolecular between ENP LCDP. significantly improve rate LCDP respectively. Compared naked system, remarkable enhancement bioavailability model drugs observed incorporated into SiO2, superior physical stability after accelerated study. Raman mapping revealed less microstructure phase separation could be main reason for better in presence SiO2. conclusion, successfully used poorly water-soluble collaborates become promising strategy achieve stable amorphous formulation further bioavailability.

Language: Английский

Citations

0
Nanoemulsion for enhanced absorption and anti-tumor activity of dasatinib DOI
Dina A. Eltahan, Rania K. Eid, Shimaa M. Ashmawy

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106870 - 106870

Published: March 1, 2025

Language: Английский

Citations

0
Harnessing the targeting potential of hyaluronic acid for augmented anticancer activity and safety of duvelisib-loaded nanoparticles in hematological malignancies DOI
Srushti Mahajan, Mayur Aalhate,

Essha Chatterjee

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136600 - 136600

Published: Oct. 18, 2024

Language: Английский

Citations

1
The Neoteric Paradigm of Biomolecule-Functionalized Albumin-Based Targeted Cancer Therapeutics DOI

Swati Gunjkar,

Ujala Gupta, R. Nair

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(8)

Published: Nov. 5, 2024

Language: Английский

Citations

0
“Development, optimization, and characterization of Eudragit-based nanoparticles for Dasatinib delivery” DOI

G Hemanth,

Anasuya Patil,

Hariprasad MG

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Nov. 19, 2024

This study focused on developing and evaluating dasatinib-loaded nanoparticles (DST-NPs) using Eudragit L100 as a polymer matrix for enhanced breast cancer treatment. The optimized formulation exhibited particle size of 202.1 ± 5.7 nm, zeta potential −18 1.01 mV, an entrapment efficiency 93.11 0.2%. In-vitro release studies demonstrated sustained drug from DST-NPs, following Fickian diffusion. Pharmacokinetic in rats revealed higher Cmax AUC0-t DST-NPs compared to pure DST, indicating improved bioavailability. Tissue distribution showed targeting with concentrations the liver spleen. In vivo efficacy DMBA-induced mammary carcinoma model that significantly reduced tumor volume, maintained stable body weight, survival rates DST. Hematologic analysis indicated favorable blood profile histopathological examinations confirmed restoration normal gland architecture. MTT assays cytotoxicity against MCF-7, MDA-MB231, 4T1 cell lines, lower IC50 values than Stability their properties over six months at various storage conditions. These findings highlight effective nanocarrier system therapy.

Language: Английский

Citations

0