Polymer Microspheres and Their Application in Cancer Diagnosis and Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6556 - 6556

Published: June 14, 2024

Cancer is a significant global public health issue with increasing morbidity and mortality rates. To address this challenge, novel drug carriers such as nano-materials, liposomes, hydrogels, fibers, microspheres have been extensively researched utilized in oncology. Among them, polymer are gaining popularity due to their ease of preparation, excellent performance, biocompatibility, drug-release capabilities. This paper categorizes commonly used materials for microsphere summarizes various preparation methods (emulsification, phase separation, spray drying, electrospray, microfluidics, membrane emulsification), reviews the applications cancer diagnosis, therapy, postoperative care. The current status future development directions treatment analyzed, highlighting importance potential improving patient outcomes.

Language: Английский

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Bibliometric and visual analysis of drug-specific immunotherapy from 1990 to 2024

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Specific immunotherapy (SIT) is key in allergic diseases, tumor immunity, and autoimmune regulation. In recent years, the mechanism of action drugs SIT has attracted much attention, including induction hypersensitivity responses modulation immune tolerance. However, scientific challenges remain regarding their optimization strategies. Studies on pharmacological have been accumulated past, there an urgent need for bibliometric analyses to review prospect these results future academic development. Strict search criteria were developed screen download literature information from Web Science Core Collection. Six elements included analyzed visualized using Citespace, VOSviewer software, Bibliometrix package. A total 682 publications related drug this study. The growth trend number evident entering a new phase with great potential future, highest citations 1998. countries institutions most USA University Genoa. author who contributed field was Incorvaia, Cristoforo. Moreover, Bousquet J influential author. Allergy considered leading core source journal, Journal Clinical Immunology influential. reference outbreak intensity Roberts G, 2018, Allergy, V73, P765, https://doi.org/10.1111/all.13317 . analysis keywords by various metrics shows that research hotspot tumor-associated SIT, cutting-edge topic AIT, respiratory application hot issue. Drug made good progress joint participation global institutions, scientists, journals. cooperation communication are weak, it necessary build mode promote globalization results. We found hotspots issues field, which will guide us make breakthroughs more precise direction play important role safety safeguarding human life health.

Language: Английский

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Unlocking the power of probiotics, postbiotics: targeting apoptosis for the treatment and prevention of digestive diseases

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 31, 2025

Digestive diseases are becoming an increasingly serious health burden, creating urgent need to develop more effective treatment strategies. Probiotics and postbiotics have been extensively studied for their potential prevent treat digestive diseases. Growing evidence suggests that programmed cell death, especially apoptosis, is a critical mechanism influencing the molecular biological aspects of diseases, contributing disease progression. Understanding mechanisms signaling pathways by which probiotics regulate apoptosis could reveal new therapeutic targets treating This review focuses on beneficial effects in regulating across range liver including non-alcoholic fatty disease, injury, cirrhosis, cancer. It also explores gastrointestinal such as colorectal cancer, colitis, infectious diarrhea. Furthermore, some help balance gut microbiota, enhance intestinal barrier function, immune system, all closely associated with apoptosis. Moreover, emerging technologies, encapsulation methods, developed stabilize probiotics, primarily based experimental findings from rodent human studies.

Language: Английский

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The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Colorectal cancer (CRC) ranks as the third most prevalent worldwide. It is associated with imbalanced gut microbiota. Probiotics can help restore this balance, potentially reducing risk of CRC. However, hostile environment and constant changes in gastrointestinal tract pose significant challenges to efficient delivery probiotics colon. Traditional methods are often insufficient due their low viability lack targeting. To address these challenges, researchers increasingly focusing on innovative encapsulation technologies. One such approach single‐cell encapsulation, which involves applying nanocoatings individual probiotic cells. This technique improve resistance harsh environment, enhance mucosal adhesion, facilitate targeted release, thereby increasing effectiveness delivery. article reviews latest developments for CRC treatment, emphasizing potential benefits emerging techniques. also analyzes compares advantages disadvantages current Furthermore, it elucidates underlying mechanisms through prevent treat CRC, evaluates efficacy safety treatment adjuvant therapy, discusses future directions prevention.

Language: Английский

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Preparation and characterization of microcapsules using an acid-tolerant sanxan gum combined with sodium alginate/chitosan and their application in Lactobacillus plantarum delivery

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123638 - 123638

Published: April 1, 2025

Language: Английский

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Single-cell technologies for dissecting heterogeneity in oral tumours: Implications for precision therapy

Oral Oncology Reports, Journal Year: 2024, Volume and Issue: 10, P. 100460 - 100460

Published: April 29, 2024

• Single-cell tech reveals oral tumor heterogeneity, molecular signatures subpopulations driving growth, resistance for novel agents maps microenvironment, defines cell communication networks

Language: Английский

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Effect of colorectal cancer stem cells on the development and metastasis of colorectal cancer

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(11), P. 4354 - 4368

Published: Oct. 25, 2024

The relevant mechanism of tumor-associated macrophages (TAMs) in the treatment colorectal cancer patients with immune checkpoint inhibitors (ICIs) is discussed, and application prospects TAMs reversing tolerance ICIs are discussed to provide a reference for related studies. As class drugs widely used clinical tumor immunotherapy, can act on regulatory molecules cells that play an inhibitory role - checkpoints kill tumors form response by activating variety system. sensitivity different types ICI varies greatly. phenotype function microenvironment closely efficacy ICIs. regulate phenotypic TAMs, also affect therapy. important resistance, making full use this target as therapeutic strategy expected improve immunotherapy prognosis cancer.

Language: Английский

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