The
skin
exhibits
a
hierarchical
structure,
and
the
application
of
tissue
engineering
techniques
is
recommended
for
treatment
severe
cutaneous
injuries.
To
biologically
mimic
structural
characteristics
distinct
layers
skin,
utilization
multilayered
scaffolds
has
become
prominent
approach.
In
current
study,
an
asymmetric
trilayered
scaffold
was
fabricated,
consisting
middle
layer
(ML)
composed
3D
printed
poly(vinyl
alcohol)-carrageenan
(PVA.Crg),
top
(TL)
nanofibrous
polycaprolactone-propolis
(PCL.Pp),
bottom
(BL)
alcohol)-fucoidan-deferoxamine
(PVA.Fu.Def)
nanofibers.
It
indicated
that
tensile
strength
elastic
modulus
trilayer
were
significantly
higher
compared
to
other
samples.
in
vitro
degradation
rate
studied
as
well
release
Def
from
after
7
days
quantified
within
range
36-40
91.1%,
respectively.
did
not
induce
cytotoxicity
chicken
chorioallantoic
membrane
assay
revealed
remarkably
enhanced
angiogenesis.
Furthermore,
vivo
examinations
exhibited
fastest
re-epithelialization
group
treated
with
containing
Def.
findings
this
study
suggest
potential
fabricated
substitute
or
wound
dressing.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(19), P. 24351 - 24371
Published: May 1, 2024
Chronic
nonhealing
wounds
are
serious
complications
of
diabetes
with
a
high
morbidity,
and
they
can
lead
to
disability
or
death.
Conventional
drug
therapy
is
ineffective
for
diabetic
wound
healing
because
the
complex
environment
depth
penetration.
Here,
we
developed
self-healing,
dual-layer,
drug-carrying
microneedle
(SDDMN)
healing.
This
SDDMN
realize
transdermal
delivery
broad-spectrum
sterilization
without
resistance
meets
multiple
needs
process.
Quaternary
ammonium
chitosan
cografted
dihydrocaffeic
acid
(Da)
l-arginine
oxidized
hyaluronic
acid-dopamine
main
parts
self-healing
hydrogel
patch.
Methacrylated
poly(vinyl
alcohol)
(methacrylated
PVA)
phenylboronic
(PBA)
were
used
as
part
MN,
gallium
porphyrin
modified
3-amino-1,2
propanediol
(POGa)
insulin
encapsulated
at
its
tip.
Under
hyperglycaemic
conditions,
PBA
moiety
in
MN
reversibly
formed
glucose-boronic
that
promoted
rapid
release
POGa
insulin.
disguised
hemoglobin
through
Trojan-horse
strategy,
which
then
taken
up
by
bacteria,
allowing
it
target
bacteria
infected
lesions.
Based
on
synergistic
properties
these
components,
SDDMN-POGa
patches
exhibited
an
excellent
biocompatibility,
slow
release,
antimicrobial
properties.
Thus,
provide
potential
therapeutic
approach
treatment
wounds.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 2, 2024
Abstract
Severe
cutaneous
injuries
may
not
heal
spontaneously
and
necessitate
the
use
of
supplementary
therapeutic
methods.
Electrospun
nanofibers
possess
high
porosity
specific
surface
area,
which
provide
necessary
microenvironment
for
wound
healing.
Here
in,
Soluplus-soy
protein
isolate
(Sol-SPI)
containing
mupirocin
(Mp)
were
fabricated
via
electrospinning
treatment.
The
exhibited
water
absorption
capacities
about
300.83
±
29.72%
vapor
permeability
values
821.8
49.12
g/m
2
day.
Sol/SPI/Mp
showed
an
in
vitro
degradability
33.73
3.55%
after
5
days.
ultimate
tensile
strength,
elastic
modulus,
elongation
measured
as
3.61
0.29
MPa,
39.15
5.08
59.11
1.94%,
respectively.
Additionally,
85.90
6.02%
Mp
loaded
was
released
days
vitro,
by
applying
Mp-loaded
nanofibers,
93.06
5.40%
90.40
5.66%
S.
aureus
E.
coli
bacteria
killed,
Human
keratinocyte
cells
(HaCat)
demonstrated
notable
biocompatibility
with
prepared
nanofibers.
Furthermore,
compare
to
other
groups,
Sol-SPI-Mp
caused
fastest
re-epithelialization
healing
a
rat
model.
findings
this
study
present
novel
nanofiber-based
dressing
that
accelerates
severe
skin
wounds
risk
infection.
