Erlotinib and curcumin-loaded nanoparticles embedded in thermosensitive chitosan hydrogels for enhanced treatment of head and neck cancer DOI
Mohamed Haider, Jayalakshmi Jagal, Maha Al‐Ghamdi

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 666, P. 124825 - 124825

Published: Oct. 12, 2024

Language: Английский

Polysarcosine functionalised cationic polyesters efficiently deliver self-amplifying mRNA DOI Creative Commons
Hulya Bayraktutan, Rafał J. Kopiasz, Amr Elsherbeny

et al.

Polymer Chemistry, Journal Year: 2024, Volume and Issue: 15(18), P. 1862 - 1876

Published: Jan. 1, 2024

In this work we demonstrate the endcapping of a poly(beta-amino ester) polysarcosine, widely established PEG-alternative, and show its ability as non-viral vector for self-amplifying mRNA.

Language: Английский

Citations

3
Curcumin-Loaded Zein Nanoparticles: A Quality by Design Approach for Enhanced Drug Delivery and Cytotoxicity against Cancer Cells DOI

Jayalakshmi Cs,

Mohamed Haider, Mutasem Rawas‐Qalaji

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114319 - 114319

Published: Oct. 16, 2024

Language: Английский

Citations

2
Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine DOI Creative Commons
Hulya Bayraktutan,

Peter Symonds,

Victoria A. Brentville

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122647 - 122647

Published: June 5, 2024

DNA technology has emerged as a promising route to accelerated manufacture of sequence agnostic vaccines. For activity, vaccines must be protected and delivered the correct antigen presenting cells. However, physicochemical properties vector carefully tuned enhance interaction with immune cells generate sufficient response for disease protection. In this study, we have engineered range polymer-based nanocarriers based on poly(beta-amino ester) (PBAE) polycation platform investigate role that surface poly(ethylene glycol) (PEG) density pDNA encapsulation, formulation gene transfectability both in vitro vivo. We achieved by synthesising non-PEGylated PEGylated PBAE produced formulations containing these PBAEs, mixed polyplexes tune PEG density. All polymers co-formulations small polyplex nanoparticles almost complete encapsulation cargo all cases. Despite high transfection HEK293T cells, only fully displayed significantly higher expression reporter than negative control dendritic Further vivo studies bivalent SARS-CoV-2 vaccine revealed led strong specific T-cell responses, however did not translate into presence serum antibodies indicating need further improving immunisation polymer delivery systems.

Language: Английский

Citations

1
Erlotinib and curcumin-loaded nanoparticles embedded in thermosensitive chitosan hydrogels for enhanced treatment of head and neck cancer DOI
Mohamed Haider, Jayalakshmi Jagal, Maha Al‐Ghamdi

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 666, P. 124825 - 124825

Published: Oct. 12, 2024

Language: Английский

Citations

1