Improvement of solubility, dissolution, and bioavailability of phenytoin intercalated in Mg-Al layered double hydroxide DOI Creative Commons

Rehab Anwar Bakr,

Sabna Kotta,

Hibah Mubarak Aldawsari

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 2, 2024

Layered double hydroxides (LDHs) are highly effective drug delivery systems, owing to their capacity intercalate or adsorb biomaterials, flexible structure, swelling property, high stability, good biocompatibility, and ease of synthesis. Phenytoin (PHT) is an antiseizure BCS (Biopharmaceutics Classification System) class II drug, presenting low aqueous solubility. Therefore, the current study aimed at increasing its solubility, dissolution, bioavailability. PHT was intercalated MgAl-LDH formed

Language: Английский

Advances in artificial intelligence for drug delivery and development: A comprehensive review DOI
Amol D. Gholap, Md Jasim Uddin, Md. Faiyazuddin

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 178, P. 108702 - 108702

Published: June 7, 2024

Language: Английский

Citations

41
Overview of 3d Printing Technology with Pharmaceutical Applications, Challenges and Future Aspects DOI Open Access

Vanshika Sautha,

Mansi Butola, Meenu Chaudhary

et al.

Biomedical & Pharmacology Journal, Journal Year: 2025, Volume and Issue: 18(December Spl Edition), P. 17 - 32

Published: Jan. 20, 2025

Since its beginnings in the 1980s, 3D printing has transformed several research areas, including pharmaceutical sector. The primary objective is to manufacture complex, customized products using a cost-effective, on-demand manufacturing process. In past decade, gained interest of groups for development various drug delivery systems. Advantages technologies over traditional procedures include modification pharmaceuticals with dosages, capability produce complex solid dosage forms, manufacturing, and cost efficiency. Nonetheless, although technology potential medical economic advantages, some technological regulatory obstacles limit wide application products. Thus, further innovation refinement processes must address existing limitations provide patient-specific healthcare drugs on demand. This review presents useful their treatment disorders, demonstrating this regular commercial production.

Language: Английский

Citations

1
The Future of Medicine: How 3D Printing Is Transforming Pharmaceuticals DOI Creative Commons
Jurga Bernatonienė, Jolita Stabrauskiene, Jurga Andrėja Kazlauskaitė

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 390 - 390

Published: March 19, 2025

Three-dimensional printing technology is transforming pharmaceutical manufacturing by shifting from conventional mass production to additive manufacturing, with a strong emphasis on personalized medicine. The integration of bioinks and AI-driven optimization further enhancing this innovation, enabling drug precise dosages, tailored drug-release profiles, unique multi-drug combinations that respond individual patient needs. This advancement significantly impacting healthcare accelerating development, encouraging innovative designs, treatment efficacy. Traditional follows one-size-fits-all approach, which often fails meet the specific requirements patients medical conditions. In contrast, 3D printing, coupled bioink formulations, allows for on-demand production, reducing dependency large-scale storage. AI-powered design process refine dosage forms, printability, release mechanisms, ensuring precision efficiency in manufacturing. These advancements have potential lower overall costs while improving adherence medication regimens. review explores potential, challenges, environmental benefits positioning it as key driver next-generation

Language: Английский

Citations

1
Drug delivery strategies to improve the treatment of corneal disorders DOI Creative Commons

Mahsa Fallah Tafti,

Zeinab Fayyaz,

Hossein Aghamollaei

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e41881 - e41881

Published: Jan. 1, 2025

Anterior eye disorders including dry syndrome, keratitis, chemical burns, and trauma have varying prevalence rates in the world. Classical dosage forms based-topical ophthalmic drugs are popular treatments for managing corneal diseases. However, current of ocular can be associated with major challenges such as short retention time presence barriers. Developing alternative therapeutic methods is required to overcome drug bioavailability from Nanocarriers platforms promising candidates administration an adjustable manner. This paper briefly introduces advantages, disadvantages, characteristics delivery systems treatment Additionally, advanced technologies 3D printing being considered fabricate carriers determine dosages personalized treatment. comprehensive review gathered through multiple databases Google Scholar, PubMed, Web Science. It explores information around "ocular systems'', "nano-based "engineered nanocarriers'', "advanced systems''.

Language: Английский

Citations

0
AN OVERVIEW OF 3D PRINTING TECHNOLOGIES FOCUSING MULTIDRUG-LOADED 3D PRINTED DOSAGE FORMS DOI Open Access
Aysel Yılmaz, N. Başaran Mutlu Ağardan, Sevgi Takka

et al.

Ankara Universitesi Eczacilik Fakultesi Dergisi, Journal Year: 2025, Volume and Issue: 49(1), P. 28 - 28

Published: Jan. 11, 2025

Objective: This review focuses on multidrug-loaded dosage forms produced with three-dimensional printing (3DP) technologies since the confirmation of Spritam®, first 3D printed form, in 2015. Result and Discussion: The integration multiple drugs within a single form through 3DP offers substantial flexibility design, allowing for customization dosage, drug release profiles, geometric structures. These formulations offer significant design by combining different unit, have potential to optimize treatment strategies, especially diseases requiring use. wide literature search reveals that most commonly used method is Fused Deposition Modeling (FDM) obtain various geometries, such as multi-compartment capsules or tablets, bi-layered multi-layered tablets exhibiting kinetics, core/shell structured tablets. Multidrug-loaded 3D-printed individualizing fixed-dose combinations become promising tool advancing personalized medicine improving therapeutic outcomes polypharmacy. innovative approach can efficacy, reduce side effects, improve patient compliance. As research continues expand, these represent direction future development strategies.

Language: Английский

Citations

0
Use of Computational Intelligence in Customizing Drug Release from 3D-Printed Products: A Comprehensive Review DOI Creative Commons
Fantahun Molla Kassa, Souha H. Youssef, Yunmei Song

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 551 - 551

Published: April 23, 2025

Computational intelligence (CI) mimics human by expanding the capabilities of machines in data analysis, pattern recognition, and making informed decisions. CI has shown promising contributions to advancements drug discovery, formulation, manufacturing. Its ability analyze vast amounts patient optimize formulations predicting pharmacokinetic pharmacodynamic responses makes it a very useful platform for personalized medicine. The integration with 3D printing further strengthens this potential, as enables fabrication medicines precise doses, controlled-release profiles, complex formulations. Furthermore, automated digital make suitable CI. proven material printability, optimizing release rates, designing structures, ensuring quality control, improving manufacturing processes printing. In context customizing from 3D-printed products, techniques have been applied predict input variables design geometries that achieve desired profile. This review explores role It provides overview limitations printing; how can overcome these challenges, its potential release; comparison other methods optimization; real-world examples

Language: Английский

Citations

0
Explicating the transformative role of artificial intelligence in designing targeted nanomedicine DOI

Masheera Akhtar,

Nida Nehal,

Azka Gull

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Artificial intelligence (AI) has emerged as a transformative force in nanomedicine. revolutionizing drug delivery, diagnostics, and personalized treatment. While nanomedicine offers precise targeted delivery reduced toxic effects, its clinical translation is hindered by biological complexity, unpredictable vivo behavior, inefficient trial-and-error approaches. This review covers the application of AI Machine Learning (ML) across development pipeline, starting from target identification to nanoparticle design, toxicity prediction, dosing. Different AI/ML models like QSAR, MTK-QSBER, Alchemite, along with data sources high-throughput screening methods, have been explored. Real-world applications are critically discussed, including AI-assisted repurposing, controlled-release formulations, cancer-specific systems. an essential component designing next-generation Efficiently handling multidimensional datasets, optimizing personalizing treatment regimens, it sped up innovation process. However, challenges heterogeneity, model transparency, regulatory gaps remain. Addressing these hurdles through interdisciplinary efforts emerging innovations explainable federated learning will pave way for AI-driven

Language: Английский

Citations

0
3D printing for controlled release Pharmaceuticals: Current trends and future directions DOI

Mingyue Deng,

Siyi Wu, Meiying Ning

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125089 - 125089

Published: Dec. 16, 2024

Language: Английский

Citations

2
Improvement of solubility, dissolution, and bioavailability of phenytoin intercalated in Mg-Al layered double hydroxide DOI Creative Commons

Rehab Anwar Bakr,

Sabna Kotta,

Hibah Mubarak Aldawsari

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 2, 2024

Layered double hydroxides (LDHs) are highly effective drug delivery systems, owing to their capacity intercalate or adsorb biomaterials, flexible structure, swelling property, high stability, good biocompatibility, and ease of synthesis. Phenytoin (PHT) is an antiseizure BCS (Biopharmaceutics Classification System) class II drug, presenting low aqueous solubility. Therefore, the current study aimed at increasing its solubility, dissolution, bioavailability. PHT was intercalated MgAl-LDH formed

Language: Английский

Citations

0