The antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability DOI Creative Commons
Chong Li, Yu Tian Wang, Wenjing Zhang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 11, 2024

Glabridin, a flavonoid derived from the plant

Language: Английский

Disulfiram-Loaded PLGA nanoparticles modified with a Phenyl borate chitosan Conjugate enhance hepatic carcinoma treatment DOI

Yanyi Feng,

Hongyu Chen, Simiao Chen

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125293 - 125293

Published: Jan. 1, 2025

Language: Английский

Citations

0
Disulfiram-loaded electrospun fibers with antimicrobial and antitumoral properties for glioblastoma treatment DOI Creative Commons

Iago Gonzalez-Prada,

Arthur Barcelos Ribeiro,

Marine Dion

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113615 - 113615

Published: March 12, 2025

Glioblastoma (GB) is a malignant brain tumor with low survival rates and high recurrence ratio due to limited therapeutic arsenal. The repurposed drug disulfiram (DSF), approved for alcoholism treatment, shows promising anticancer antimicrobial activity, but its poor biopharmaceutical profile hinders clinical use. This work aimed develop DSF-loaded silk fibroin (SF) electrospun fibers controlled release in the postsurgical resection cavity. Incorporating hydroxypropyl-β-cyclodextrin (HPβCD), which formed inclusion complexes DSF, enhanced rate activity (>3 logCFUs reduction) against Staphylococcus aureus Pseudomonas aeruginosa. Addition of CuCl2 enabled situ formation Cu(DDC)2 complexes, further boosting vitro antitumoral effects nanofibers (≤ 500 nm) while maintaining adequate mechanical properties. Selective toxicity DSF glioblastoma cells, sparing astrocytes, highlights potential targeted cancer therapy. Increased potency at concentrations when combined SF fibers, HPβCD copper was remarkable. Thus, delivery bioavailability can be significantly optimized through nanofibers, may also allow more precise dosing. Combination radiotherapy explored assess translational as part combination therapy regimen glioblastoma. In vivo studies rat model simulating GB surgery confirmed safety selected formulations healthy tissue. However, findings suggest that alone insufficient complete eradication, indicating need existing therapies target residual cells effectively.

Language: Английский

Citations

0
Drug functional remapping: a new promise for tumor immunotherapy DOI Creative Commons
Jiayi Dong, Ting Su, Jun Wu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 14, 2025

The research and development of new anti-cancer drugs face challenges such as high costs, lengthy cycles, limited data on side effects. In contrast, the clinical safety effects traditional have been well established through long-term use. or repurposing with potential applications in cancer treatment offers an economical, feasible, promising strategy for drug development. This article reviews novel tumor immunotherapy, discussing how they can enhance efficacy functional repositioning, while also reducing time costs. Recent advancements immunotherapy revolutionized options, but resistance to ICIs remains a significant challenge. Drug has emerged identify agents that immunotherapies by overcoming ICI resistance. A study suggests repositioning modulate immune cell activity alter microenvironment, thereby circumventing mechanisms associated checkpoint blockade. approach provides rapid cost-effective pathway identifying therapeutic candidates be quickly transitioned into trials. To improve effectiveness it is crucial explore systematic methods repurposed candidates. Methods high-throughput screening, computational bioinformatic analysis employed efficiently treatment. Furthermore, leveraging databases related provide valuable resources discovery facilitate identification compounds. It focuses latest use antidiabetic drugs, antihypertensive agents, weight-loss medications, antifungal antiviral examining their action, application prospects, challenges. this context, our aim these strategies highlight expanding options available providing references

Language: Английский

Citations

0
Hydroxy propyl β-cyclodextrin complexes of Olaparib: Amalgamation of in silico, in vitro and in vivo approaches for Bioavailability Enhancement DOI

Paras Famta,

Saurabh Shah,

Abhishek Sharma

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142077 - 142077

Published: March 1, 2025

Language: Английский

Citations

0
The encapsulation of isoeugenol in the cavity of β-cyclodextrin and the interaction mechanism of the two molecules DOI
Guangyong Zhu, Xue Y. Zhu

Structural Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

Citations

0
Advances in cyclodextrin-based materials: Anticancer and antimicrobial applications–A review (2021–2024) DOI
Alaa Shafie, Amal Adnan Ashour

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113672 - 113672

Published: April 1, 2025

Language: Английский

Citations

0
Parallel (competitive) reactions of micelle formation and cyclodextrin–surfactant inclusion complex formation in aqueous solution: A consequence of the Gibbs–Duhem equation—invariance of the mass action law and the possibility of determining the equilibrium constant of the inclusion complex DOI
Mihalj Poša

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 415, P. 126409 - 126409

Published: Nov. 7, 2024

Language: Английский

Citations

0
The antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability DOI Creative Commons
Chong Li, Yu Tian Wang, Wenjing Zhang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 11, 2024

Glabridin, a flavonoid derived from the plant

Language: Английский

Citations

0