Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 206 - 206
Published: March 15, 2025
Hydrogel
microneedles
(HMNs)
have
emerged
as
a
transformative
platform
for
minimally
invasive
drug
delivery
and
biosensing,
offering
enhanced
bioavailability,
controlled
release,
real-time
biomarker
detection.
By
leveraging
swelling
hydrogels,
nanomaterial
integration,
stimuli-responsive
properties,
HMNs
provide
precision
medicine
capabilities
across
diverse
therapeutic
diagnostic
applications.
However,
challenges
remain
in
mechanical
stability,
hydrogel-based
MNs
must
balance
flexibility
with
sufficient
strength
skin
penetration.
Drug
retention
release
require
optimization
to
prevent
premature
diffusion
ensure
sustained
effects.
Additionally,
biosensing
accuracy
is
influenced
by
variability
interstitial
fluid
extraction
signal
transduction.
Clinical
translation
hindered
regulatory
hurdles,
scalability
concerns,
the
need
extensive
safety
validation
human
trials.
This
review
critically
examines
key
materials,
fabrication
techniques,
functional
testing
frameworks
of
while
addressing
these
limitations.
Furthermore,
we
explore
future
research
directions
smart
wearable
MNs,
AI-assisted
hybrid
drug–device
platforms
optimize
transdermal
medicine.
Overcoming
barriers
will
drive
clinical
adoption
HMNs,
paving
way
next-generation
patient-centered
therapeutics
diagnostics.
Language: Английский
Fabrication of Hybrid Coated Microneedles with Donepezil Utilizing Digital Light Processing and Semisolid Extrusion Printing for the Management of Alzheimer’s Disease
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(9), P. 4450 - 4464
Published: Aug. 20, 2024
Microneedle
(MN)
patches
are
gaining
increasing
attention
as
a
cost-effective
technology
for
delivering
drugs
directly
into
the
skin.
In
present
study,
two
different
3D
printing
processes
were
utilized
to
produce
coated
MNs,
namely,
digital
light
processing
(DLP)
and
semisolid
extrusion
(SSE).
Donepezil
(DN),
cholinesterase
inhibitor
administered
treatment
of
Alzheimer's
disease,
was
incorporated
coating
material.
Physiochemical
characterization
MNs
confirmed
successful
incorporation
donepezil
well
stability
suitability
materials
transdermal
delivery.
Optical
microscopy
SEM
studies
validated
uniform
weight
distribution
precise
dimensions
MN
arrays,
while
mechanical
testing
ensured
MNs'
robustness,
ensuring
efficient
skin
penetration.
vitro
conducted
evaluate
produced
patches,
indicating
their
potential
use
in
clinical
treatment.
Permeation
revealed
significant
increase
DN
permeation
compared
plain
material,
affirming
effectiveness
enhancing
drug
Confocal
laser
scanning
(CLSM)
elucidated
API,
within
layers,
demonstrating
sustained
release
transcellular
transport
pathways.
Finally,
cell
also
on
NIH3T3
fibroblasts
biocompatibility
safety
printed
objects
applications.
Language: Английский
A Combinatorial Approach with Microneedle Pretreatment and Thermosensitive Gel Loaded with Rivastigmine Lipid Nanoparticle Formulation Enables Brain Delivery via the Trigeminal Nerve
Andi Dian Permana,
No information about this author
Muhammad Alif Sya’ban Mahfud,
No information about this author
Miftakhul Munir
No information about this author
et al.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(49), P. 68388 - 68406
Published: Nov. 26, 2024
Alzheimer's
disease
(AD)
often
leads
to
dementia,
causing
cognitive
decline
and
increased
care
needs.
Rivastigmine
(RV)
is
a
key
AD
treatment,
but
its
brain
delivery
limited
by
the
blood-brain
barrier
(BBB).
Aside
from
oral,
olfactory,
intradermal
injection
(i.d.)
routes,
application
of
polymeric
microneedles
via
trigeminal
nerve
on
facial
skin
as
pretreatment,
followed
solid
lipid
nanoparticle
RV-loaded
thermosensitive
gel
(PMN-SLN-RV-TG),
an
alternative
deal
with
problems.
This
study
aims
determine
optimal
formula
for
PMN-SLN-RV-TG
assess
ability
compared
conventional
routes.
The
optimum
SLN-RV
had
particle
size
<200
nm
sustained
release
72
h,
which
was
selected
SLN-RV-TG
formulation.
transformed
into
at
normal
temperature
(32-37
°C),
good
physical
properties
nontoxic
behavior.
ideal
PMN
able
penetrate
dermal
layer
i.d.
administration.
Language: Английский
Leveraging Nanoengineered Microneedle‐Augmented Drug Delivery in Oncological Intervention
Particle & Particle Systems Characterization,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
Abstract
The
landscape
of
chemotherapy
for
cancer
is
experiencing
a
dramatic
transition
with
the
integration
sophisticated
drug
delivery
methods,
especially
nanoengineered
microneedles.
Percutaneous
vaccination
regarded
optimum
therapeutic
approach
due
to
high
amount
immune
cell
accumulation
and
rich
capillary
lymphatic
system
in
dermis.
curative
impact
Microneedles‐based
vaccines
suboptimal
complicated
mix
tumor,
host,
environmental
variables,
as
well
vaccine's
restricted
loading
capacity.
As
result,
additional
enhancements
are
still
needed
accelerate
their
clinical
translation.
This
article
offers
meticulous
analysis
avant‐garde
strategies
harnessed
augment
via
microneedle.
Various
tactics,
such
tailored
nanoparticle
carriers,
functionalized
microneedle
arrays,
real‐time
monitoring
system,
work
together
improve
efficacy
prevent
off‐target
effects.
By
integrating
recent
advancement
delineating
future
trajectories,
this
gives
an
in‐depth
how
microneedle‐augmented
technologies
have
potential
change
face
therapy,
heralding
new
era
precision
medicine
better
outcomes.
Language: Английский
Controlled Release of Madecassoside and Asiaticoside of Centella asiatica L. Origin from Sustainable Cold-Processed Topical Formulations
Molecules,
Journal Year:
2024,
Volume and Issue:
29(23), P. 5583 - 5583
Published: Nov. 26, 2024
Centella
asiatica
L.
extract
is
a
promising
natural
agent
for
the
treatment
of
atopic
dermatitis.
It
significantly
reduces
inflammation
due
to
its
immunomodulatory
properties,
mainly
attributed
presence
pentacyclic
triterpenes,
namely
madecassoside
and
asiaticoside.
Their
incorporation
into
sustainable
cold-processed
topical
formulations,
such
as
emollient-rich
emulsions
cosmetic
gel
containing
hydrophilic
polymers,
should
inhibit
in
skin.
Therefore,
objective
this
study
investigate
controlled
release
asiaticoside
isolated
from
L.,
loaded
O/W
W/O
gel,
which
could
support
The
carriers
active
substances
have
been
prepared
with
emulsifiers,
substances,
emollients
obtained
by
green
technologies
food
industry
wastes.
Low-energy
methods
during
carrier
emulsification
process
were
applied
reduce
carbon
footprints
preserve
valuable
properties
raw
materials
used.
influence
on
physicochemical
formulations
was
studied,
showing
satisfactory
degree
stability
obtained.
Moreover,
factors
that
may
mechanism
kinetics
asiaticoside,
concentration
substance,
pH
dissolution
medium,
type
carrier,
tested
widely
discussed.
Language: Английский