Dual Metal Nanoflower Oxygen Pump Microneedles Based on Cuproptosis and STING Pathway Activation for Cancer Immunotherapy

Small, Journal Year: 2025, Volume and Issue: 21(11)

Published: Feb. 14, 2025

Abstract Immunotherapy is a promising new approach for tumor treatment. However, its clinical application hindered by insufficient immunogenicity, hypoxia, and immunosuppressive microenvironment (TME). Here, oxygen pump microneedles (OPMNs) loaded with zinc‐doped copper sulfide nanoflowers (ZCS NFs) PD‐L1 small interfering RNA (siPD‐L1) (OPMNs‐ZCS@siPD‐L1) are developed boosting immunotherapy. OPMN‐ZCS@siPD‐L1 enhances immunogenicity through ZCS NFs inducing cuproptosis, reverses TME siPD‐L1, promotes drug penetration, ameliorates hypoxia bubbles. More importantly, cuproptosis‐induced mitochondrial DNA (mtDNA) together Zn 2+ co‐activate the STING pathway, triggering robust immune response. increases sensitivity to cuproptosis induces immunogenic cell death (ICD) in vivo vitro, which significantly inhibits progression metastasis. The novel strategy of “increasing throttle” (cuproptopsis‐mediated activation & ICD effect) combined “releasing brake” (PD‐L1 inhibition improvement) provides enhancing percutaneous

Language: Английский

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The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.

Language: Английский

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A photoswitchable phase-reversible gel engine for systemic redox homeostasis remodeling and on-demand chemodynamic immunotherapy with sustainable immunostimulation

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160516 - 160516

Published: Feb. 1, 2025

Language: Английский

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Light and pH-activated nanoplatform based on oxidative stress-amplified for photodynamic and ferroptosis synergistic therapy of breast cancer

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113744 - 113744

Published: Feb. 1, 2025

Language: Английский

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Construction of pH-Responsive Copper Sulfide Nanocomposites and Their Photothermal/Chemodynamic Synergistic Antibacterial Studies

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

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New insights of transition metal sulfide nanoparticles for tumor precision diagnosis and treatment

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113871 - 113871

Published: May 1, 2025

Language: Английский

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