Particulate platform for pulmonary drug delivery: Recent advances of formulation and fabricating strategies DOI
Zhibin Zhang, Mengya Jin, Xinyu Yang

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125601 - 125601

Published: April 1, 2025

Language: Английский

Advances in Lipid Nanoparticle‐Based Disease Treatment DOI Open Access
Yujie Zhou,

Qiqi Ge,

Xin Wang

et al.

ChemMedChem, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Lipid nanoparticles (LNPs) have emerged as a transformative platform for the targeted delivery of therapeutic agents, revolutionizing treatment paradigms across spectrum diseases. Since inception liposomes in 1960s, lipid‐based nanotechnology has evolved to address limitations such poor bioavailability, off‐target effects, and instability, thereby enhancing efficacy safety drug administration. This review highlights latest advancements LNPs technology, focusing on their application cancer therapy, gene infectious disease management, glaucoma, other clinical areas. Recent studies underscore potential deliver messenger RNA (mRNA) small interfering (siRNA) precise genetic intervention, exemplified by breakthroughs interference CRISPR‐Cas9 genome editing. Additionally, been successfully employed ameliorate conditions, demonstrating versatility addressing both acute chronic disorders. However, challenges persist concerning large‐scale manufacturing, long‐term stability, comprehensive evaluations. Future research must focus optimizing formulations, exploring synergistic combinations with existing therapies, expanding scope treatable The integration into personalized medicine exploration applications diseases represent promising avenues further investigation. are poised play an increasingly central role development next‐generation therapeutics.

Language: Английский

Citations

1
Recent Advances in Drying and Development of Solid Formulations for Stable mRNA and siRNA Lipid Nanoparticles DOI

Kinnari Santosh Arte,

Manlin Chen,

Chanakya Patil

et al.

Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

4
Choice of organic solvent affects function of mRNA-LNP; pyridine produces highly functional mRNA-LNP DOI Creative Commons
Koki Ogawa,

Tatsuaki Tagami,

Shinji Miyake

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125367 - 125367

Published: Feb. 1, 2025

Language: Английский

Citations

0
Particulate platform for pulmonary drug delivery: Recent advances of formulation and fabricating strategies DOI
Zhibin Zhang, Mengya Jin, Xinyu Yang

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125601 - 125601

Published: April 1, 2025

Language: Английский

Citations

0