Long-term versus short-term stress physical stability assessment of pharmaceutical nano- and microsuspensions

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 677, P. 125646 - 125646

Published: April 26, 2025

Language: Английский

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Machine learning strengthened formulation design of pharmaceutical suspensions

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124967 - 124967

Published: Nov. 1, 2024

Many different formulation strategies have been investigated to oppose suboptimal treatment of long-term or chronic conditions, one which are the nano- and microsuspensions prepared as long-acting injectables prolong release an active pharmaceutical compound for a defined period time by regulating size particles milling. Typically, surfactant and/or polymers added in dispersion medium suspension during processing stabilization purposes. However, current investigations with milling heavily based on prior expertise trial-and-error approaches. Various interacting parameters such bead size, stabilizer type concentration confounded investigation process. The present study systematically exploited statistical machine learning (ML) understand relationship between characteristics under full-factorial experiments. Stabilizer was identified significant factor (p < 0.001) median diameter (D

Language: Английский

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Two in One: Size Characterization and Accelerated Short-Term Physical Stability of Dual-Drug Suspensions with Two Acidic Compounds (Indomethacin and Naproxen)

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1495 - 1495

Published: Nov. 21, 2024

Background/Objectives: Co-delivering dual-drug systems have proven to be effective in, for example, anticancer therapy or HIV prophylaxis due a higher target selectivity and therapeutic efficacy from compound synergism. However, various challenges regarding physical stability can arise during the formulation definition when multiple drug compounds are included in same formulation. In this work, focus was on aqueous suspensions, which could applied as long-acting injectable formulations release over weeks months after administration. Methods: It possible gain insights into nano- microsuspensions containing two acidic (indomethacin naproxen) prepared by milling with dual centrifugation. Information of individual suspensions subtracted compared conditions stored at elevated temperatures 40 °C. Results: Distinct particle size profiles were obtained dependent stabilizer used both suspensions. Most notably, combination indomethacin naproxen one resulted smaller sizes particles under presence some stabilizers. The further indicated that least model needed sufficiently stabilized obtain physically stable 28 days Similarly, distribution showed monomodal achieved demonstrated alone. Over 28-day period, smallest polysorbate 85 poloxamer 338 only single preparation, indicating tendencies towards stabilization synergism stabilizers well compounds. Conclusion: Overall, study preparation naproxen.

Language: Английский

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Design of Nanocrystalline Suspension of Dutasteride for Intramuscular Prolonged Delivery

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(22), P. 1781 - 1781

Published: Nov. 5, 2024

The aim of the study is to formulate an injectable nanocrystalline suspension (NS) dutasteride (DTS), a hydrophobic 5α-reductase inhibitor used treat benign prostatic hyperplasia and scalp hair loss, for parenteral long-acting delivery. A DTS-loaded NS (DTS-NS, 40 mg/mL DTS) was prepared using lab-scale bead-milling technique. optimized DTS-NS Tween 80 (0.5%

Language: Английский

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