Enhanced and Sustained Transdermal Delivery of Oxypurinol Using Thermosensitive Gel Combined with Polymeric Solid Microneedles DOI Creative Commons

Siti Nur Fatimah S. Mohamad,

Stephanie Stephanie,

Zulfiayu Sapiun

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 10(4), P. 3500 - 3510

Published: Dec. 20, 2024

Gout is a pathological condition caused by monosodium urate crystal deposition in tissues. Allopurinol, the first-line therapy, inhibits xanthine oxidase but may be ineffective due to reduced conversion oxypurinol (OXY). Current delivery routes for OXY, including oral and intravenous routes, have drawbacks such as poor solubility patient discomfort. This study developed system integrating thermosensitive gel (TRG) containing OXY with polymeric solid microneedles (PSMNs). Molecular docking demonstrated high-affinity binding interactions between Pluronic (−2.5). The TRG, formulated F127 F68, was assessed gelation temperature, pH, spreadability, bioadhesive strength. PSMN, made from poly(vinyl alcohol) polyvinylpyrrolidone K-30 citric acid, evaluated mechanical strength skin penetration. In vitro hemolysis activity, drug release, ex vivo permeation studies were conducted. results showed stable an affinity of −2.5 ligands Pluronic. TRG formulation exhibited promising characteristics transdermal delivery. PSMN good able penetrate up 504 μm. Hemolysis testing that TSG safe ratio less than 5%. release high 2.24 ± 0.26 mg highest concentration displaying sustained profile. Ex significant difference (p < 0.05) without combination. increased 79–81% compared PSMN. successfully combined enhance OXY. These suggest new route delivery, potentially offering more efficient user-friendly treatment chronic gout. Further are needed evaluate efficacy, pharmacokinetics, pharmacodynamics, interactions, toxicity further clinical applications.

Language: Английский

Development of a curcumin-piperine nanoparticle system using dissolving microneedles for transdermal drug delivery in malaria treatment: In vitro evaluation DOI

Princes Hani Rugka Cariri,

Angeline Kondorura,

Indarty Oktafiana

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125258 - 125258

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enhanced and Sustained Transdermal Delivery of Oxypurinol Using Thermosensitive Gel Combined with Polymeric Solid Microneedles DOI Creative Commons

Siti Nur Fatimah S. Mohamad,

Stephanie Stephanie,

Zulfiayu Sapiun

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 10(4), P. 3500 - 3510

Published: Dec. 20, 2024

Gout is a pathological condition caused by monosodium urate crystal deposition in tissues. Allopurinol, the first-line therapy, inhibits xanthine oxidase but may be ineffective due to reduced conversion oxypurinol (OXY). Current delivery routes for OXY, including oral and intravenous routes, have drawbacks such as poor solubility patient discomfort. This study developed system integrating thermosensitive gel (TRG) containing OXY with polymeric solid microneedles (PSMNs). Molecular docking demonstrated high-affinity binding interactions between Pluronic (−2.5). The TRG, formulated F127 F68, was assessed gelation temperature, pH, spreadability, bioadhesive strength. PSMN, made from poly(vinyl alcohol) polyvinylpyrrolidone K-30 citric acid, evaluated mechanical strength skin penetration. In vitro hemolysis activity, drug release, ex vivo permeation studies were conducted. results showed stable an affinity of −2.5 ligands Pluronic. TRG formulation exhibited promising characteristics transdermal delivery. PSMN good able penetrate up 504 μm. Hemolysis testing that TSG safe ratio less than 5%. release high 2.24 ± 0.26 mg highest concentration displaying sustained profile. Ex significant difference (p < 0.05) without combination. increased 79–81% compared PSMN. successfully combined enhance OXY. These suggest new route delivery, potentially offering more efficient user-friendly treatment chronic gout. Further are needed evaluate efficacy, pharmacokinetics, pharmacodynamics, interactions, toxicity further clinical applications.

Language: Английский

Citations

0