Characterizing the Complex Multi-Step Degradation Kinetics of Amphotericin B in a Microemulsified Drug Delivery System
AAPS PharmSciTech,
Journal Year:
2025,
Volume and Issue:
26(3)
Published: March 12, 2025
Language: Английский
Pharmaceutical 3D Printing Technology Integrating Nanomaterials and Nanodevices for Precision Neurological Therapies
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 352 - 352
Published: March 9, 2025
Pharmaceutical
3D
printing,
combined
with
nanomaterials
and
nanodevices,
presents
a
transformative
approach
to
precision
medicine
for
treating
neurological
diseases.
This
technology
enables
the
creation
of
tailored
dosage
forms
controlled
release
profiles,
enhancing
drug
delivery
across
blood−brain
barrier
(BBB).
The
integration
nanoparticles,
such
as
poly
lactic-co-glycolic
acid
(PLGA),
chitosan,
metallic
nanomaterials,
into
3D-printed
scaffolds
improves
treatment
efficacy
by
providing
targeted
prolonged
release.
Recent
advances
have
demonstrated
potential
these
systems
in
conditions
like
Parkinson’s
disease,
epilepsy,
brain
tumors.
Moreover,
printing
allows
multi-drug
combinations
personalized
formulations
that
adapt
individual
patient
needs.
Novel
approaches,
including
stimuli-responsive
systems,
on-demand
dosing,
theragnostics,
provide
new
possibilities
real-time
monitoring
disorders.
Despite
innovations,
challenges
remain
terms
scalability,
regulatory
approval,
long-term
safety.
future
perspectives
this
suggest
its
revolutionize
treatments
offering
patient-specific
therapies,
improved
penetration,
enhanced
outcomes.
review
discusses
current
state,
applications,
nanotechnology
treatment,
highlighting
need
further
research
overcome
existing
challenges.
Language: Английский
Study of doxorubicin release carried out by pH-responsive chitosan-alginate hydrogels
Journal of Molecular Liquids,
Journal Year:
2025,
Volume and Issue:
unknown, P. 127523 - 127523
Published: April 1, 2025
Language: Английский
Advances in Nanoparticles in Targeted Drug Delivery- A Review
Results in Surfaces and Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100529 - 100529
Published: April 1, 2025
Language: Английский
Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer’s, Parkinson’s, and ALS
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12613 - 12613
Published: Nov. 24, 2024
Neurodegenerative
diseases,
such
as
Alzheimer's,
Parkinson's,
ALS,
and
Huntington's,
remain
formidable
challenges
in
medicine,
with
their
relentless
progression
limited
therapeutic
options.
These
diseases
arise
from
a
web
of
molecular
disturbances-misfolded
proteins,
chronic
neuroinflammation,
mitochondrial
dysfunction,
genetic
mutations-that
slowly
dismantle
neuronal
integrity.
Yet,
recent
scientific
breakthroughs
are
opening
new
paths
to
intervene
these
once-intractable
conditions.
This
review
synthesizes
the
latest
insights
into
underlying
dynamics
neurodegeneration,
revealing
how
intertwined
pathways
drive
course
diseases.
With
an
eye
on
most
promising
advances,
we
explore
innovative
therapies
emerging
cutting-edge
research:
nanotechnology-based
drug
delivery
systems
capable
navigating
blood-brain
barrier,
gene-editing
tools
like
CRISPR
designed
correct
harmful
variants,
stem
cell
strategies
that
not
only
replace
lost
neurons
but
foster
neuroprotective
environments.
Pharmacogenomics
is
reshaping
treatment
personalization,
enabling
tailored
align
individual
profiles,
while
diagnostics
biomarkers
ushering
era
early,
precise
disease
detection.
Furthermore,
novel
perspectives
gut-brain
axis
sparking
interest
mounting
evidence
suggests
microbiome
modulation
may
play
role
reducing
neuroinflammatory
responses
linked
neurodegenerative
progression.
Taken
together,
advances
signal
shift
toward
comprehensive,
personalized
approach
could
transform
care.
By
integrating
techniques,
this
offers
forward-looking
perspective
future
where
treatments
aim
just
manage
symptoms
fundamentally
alter
progression,
presenting
renewed
hope
for
improved
patient
outcomes.
Language: Английский
The Langmuir Monolayer as a Model Membrane System for Studying the Interactions of Poly(Butyl Cyanoacrylate) Nanoparticles with Phospholipids at the Air/Water Interface
Membranes,
Journal Year:
2024,
Volume and Issue:
14(12), P. 254 - 254
Published: Dec. 2, 2024
Poly(butyl
cyanoacrylate)
(PBCA)
nanoparticles
have
numerous
applications,
including
drug
and
gene
delivery,
molecular
imaging,
cancer
therapy.
To
uncover
the
mechanisms
underlying
their
interactions
with
cell
membranes,
we
utilized
a
Langmuir
monolayer
as
model
membrane
system.
This
approach
enabled
us
to
investigate
processes
of
penetration
reorganization
PBCA
when
deposited
in
phospholipid
subphase.
Atomic
force
microscopy
(AFM)
was
employed
visualize
Langmuir–Blodgett
(LB)
films
these
nanoparticles.
Additionally,
examined
state
Pluronic
F68,
stabilizer
suspension,
by
measuring
changes
relative
surface
area
potential
over
time
barostatic
regime
following
suspension
spreading.
Based
on
findings,
propose
mechanism
for
nanoparticle
at
air–water
interface.
Language: Английский