The Dual Roles of STAT3 in Ferroptosis: Mechanism, Regulation and Therapeutic Potential

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 4251 - 4266

Published: March 1, 2025

Ferroptosis, an iron-dependent programmed mechanism of cell death that is driven by lipid peroxidation, important pathogenic factor in oncological and non-oncological disorders. Dysregulation iron metabolism profoundly influences disease progression through ferroptosis modulation. Signal transducer activator transcription 3 (STAT3), a transcriptional regulator, regulates binding to promoters key molecules such as solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1). In this review, we described the role STAT3 supporting tumors survival suppressing malignancies, bidirectionally regulating non-tumors regulate development disease. We also reported emerging therapeutic strategies target STAT3-mediated ferroptosis, including natural phytochemicals, inhibitors, nanotechnology-enabled drug delivery systems. These advancements deepen mechanistic understanding regulation, provide new theoretical bases treat ferroptosis-related diseases.

Language: Английский

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Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(2), P. 122 - 122

Published: Jan. 16, 2025

Nano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging unique advantages nanotechnology to enhance effectiveness and specificity treatments. These utilize nanoscale carriers deliver tumor-associated antigens immunostimulatory adjuvants, facilitating targeted immune activation promoting robust antitumor responses. By improving antigen presentation localizing within tumor microenvironment, nano-oncologic can significantly increase efficacy particularly when combined with other treatment modalities. This review highlights mechanisms through which operate, their potential overcome existing limitations treatment, ongoing advancements design. Additionally, it discusses delivery approach, such as EPR effects, pH response, ultrasonic magnetic response. The combination therapy effects photothermal therapy, radiotherapy, or checkpoint inhibitors are also discussed. Overall, hold great promise for changing landscape advancing personalized medicine, paving way more effective therapeutic strategies tailored individual patient needs.

Language: Английский

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Utilizing Nanomaterials in Microfluidic Devices for Disease Detection and Treatment

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(6), P. 434 - 434

Published: March 12, 2025

Microfluidic technology has gained widespread application in the field of biomedical research due to its exceptional sensitivity and high specificity. Particularly when combined with nanomaterials, synergy between two significantly advanced fields such as precision medicine, drug delivery, disease detection, treatment. This article aims provide an overview latest achievements microfluidic nanomaterials detection It delves into applications detecting blood parameters, cardiovascular markers, neurological tumor markers. Special emphasis is placed on their roles treatment, including models vessels, blood–brain barrier, lung chips, tumors. The development emerging medical technologies, particularly skin interactive devices imaging, also introduced. Additionally, challenges future prospects current clinical are discussed. In summary, play indispensable role With continuous advancement technology, will become even more profound extensive.

Language: Английский

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Emerging biomaterials and bio-nano interfaces in pulmonary hypertension therapy: transformative strategies for personalized treatment

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 9, 2025

Pulmonary hypertension (PH) is still an aggressive and progressive illness with vascular remodeling right heart failure despite the therapeutic advances made in recent past. Biomaterials offer attractive route to break current paradigms by inducing repair, facilitating drug targeting, allowing dynamic regeneration of tissue. This review taking integrated approach investigates revolutionary role played novel biomaterials bio–nano interfaces PH treatment. We classify evaluate several classes biomaterial platforms including natural polymers, scaffolds based on synthetic extracellular vesicles (EVs), stimulus-responsive systems emphasis both underlying mechanisms clinical relevance. further address progress artificial intelligence (AI)-based integrating multi-omics tools provide patient-tailored therapy. finally touch ongoing limitations enumerate future directions required take forward biomaterial-based therapies towards reality.

Language: Английский

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Stimuli-responsive nanoparticles for lung disorder treatment: From serendipity to precision phosphorylation modulation and drug repurposing

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 7, P. 100182 - 100182

Published: Jan. 1, 2025

Language: Английский

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Development and characterization of pH-sensitive zerumbone-encapsulated liposomes for lung fibrosis via inhalation Route

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 114599 - 114599

Published: Nov. 1, 2024

Language: Английский

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Identification of genetic associations between acute myocardial infarction and non-small cell lung cancer

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 6, 2024

A growing body of evidence suggests a potential connection between myocardial infarction (MI) and lung cancer (LC). However, the underlying pathogenesis molecular mechanisms remain unclear. This research aims to identify common genes pathways MI LC through bioinformatics analysis.

Language: Английский

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