Nanomedicine approaches to enhance the effectiveness of meropenem: a strategy to tackle antimicrobial resistance

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 1, 2025

Meropenem, a carbapenem typically reserved for treating severe infections, has encountered resistance from certain bacteria, including multidrug-resistant (MDR) strains of Pseudomonas aeruginosa (P. aeruginosa) and Klebsiella pneumonia (K. pneumonia). Nanoparticles (NPs) have emerged as promising strategy to combat drug-resistant bacteria. By targeting specific biosynthetic enzymatic pathways penetrating bacterial membranes, NPs can function antibiotic delivery systems (nanocarriers) or exhibit intrinsic antibacterial properties. When combined with various types nanoparticles-such lipid- polymer-based NPs, metallic silica nanoemulsions, niosomes, carbon nanocomposites-meropenem shown enhanced effectiveness in overcoming MDR bacteria reducing adverse effects. However, several challenges persist, scaling up industrial production, ensuring safety favorable toxicity profiles, addressing the limited availability vivo evidence. This review explores nanoparticle strategies meropenem.

Language: Английский

Study of doxorubicin release carried out by pH-responsive chitosan-alginate hydrogels

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127523 - 127523

Published: April 1, 2025

Language: Английский