pH-sensitive lyotropic liquid crystal beads designed for oral zero-order extended drug release DOI Creative Commons

Eliezer Goldmünz,

Abraham Aserin, Ananya Pal

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125412 - 125412

Published: March 1, 2025

The present study introduces a novel formulation approach for utilizing Lyotropic Liquid Crystals (LLCs) as sustained oral delivery systems. For this purpose, we have developed bottom-up fabrication process that enables the LLC beads to be formulated with precise control over their diameter by pre-determining surface area. By directly controlling effective diffusional interfacial of LLCs, release rate from can determined. were pH-responsive systems, attenuating Higuchian primary burst in gastric environment, and increasing solubilized load at an elevated pH environment (pH 6.4). To demonstrate applicability approach, loaded lipophilic low water solubility (< 5 µg/mL) model drug, Celecoxib (CLXB). Although CLXB is not dependent, CLXB's constant increased 9.31 1.5 15.03 6.4. dependency was achieved co-solubilization additional compounds structure, creating pH-dependent influences both structure co-solubilized compounds. enhanced gaining zero-order (R2 > 0.99) profile extending beyond 10 h medium simulating gastrointestinal (GI) tract environment. Additionally, investigated association between micellar using techniques such small-angle X-ray diffraction, nuclear magnetic resonance, electron paramagnetic resonance. results revealed co-dependent relationship changes curvature LLCs different levels, suggesting compensatory mechanism operates these two processes. These insights, combined innovative method beads, provide valuable tools enhancing effectiveness controlled

Language: Английский

pH-sensitive lyotropic liquid crystal beads designed for oral zero-order extended drug release DOI Creative Commons

Eliezer Goldmünz,

Abraham Aserin, Ananya Pal

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125412 - 125412

Published: March 1, 2025

The present study introduces a novel formulation approach for utilizing Lyotropic Liquid Crystals (LLCs) as sustained oral delivery systems. For this purpose, we have developed bottom-up fabrication process that enables the LLC beads to be formulated with precise control over their diameter by pre-determining surface area. By directly controlling effective diffusional interfacial of LLCs, release rate from can determined. were pH-responsive systems, attenuating Higuchian primary burst in gastric environment, and increasing solubilized load at an elevated pH environment (pH 6.4). To demonstrate applicability approach, loaded lipophilic low water solubility (< 5 µg/mL) model drug, Celecoxib (CLXB). Although CLXB is not dependent, CLXB's constant increased 9.31 1.5 15.03 6.4. dependency was achieved co-solubilization additional compounds structure, creating pH-dependent influences both structure co-solubilized compounds. enhanced gaining zero-order (R2 > 0.99) profile extending beyond 10 h medium simulating gastrointestinal (GI) tract environment. Additionally, investigated association between micellar using techniques such small-angle X-ray diffraction, nuclear magnetic resonance, electron paramagnetic resonance. results revealed co-dependent relationship changes curvature LLCs different levels, suggesting compensatory mechanism operates these two processes. These insights, combined innovative method beads, provide valuable tools enhancing effectiveness controlled

Language: Английский

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