Novel neural activity profiles underlying inhibitory control deficits of clinical relevance in ADHD – insights from EEG tensor decomposition

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Attention-Deficit-Hyperactivity Disorder (ADHD) is a multifaceted neurodevelopmental disorder that impacts cognitive control processes. While neurophysiological data (e.g., EEG data) have provided valuable insights into its underlying mechanisms, fully understanding the altered functions in ADHD requires advanced analytical approaches capable of capturing highly dimensional nature more effectively. We examined N=59 individuals with and N=63 neurotypical participants using standard Go/Nogo task to assess response inhibition. used tensor decomposition extract spectral, temporal, spatial trial-level features associated inhibitory deficits ADHD. The capture intra-individual variability which then machine learning analysis differentiate from participants. also applied feature selection algorithm identify most important for distinguishing between two groups classification process. observed typical inhibition Contrary common assumptions, fronto-central theta band activity did not appear be individuals. Instead, are components reflecting posterior alpha during attentional time windows windows. identified novel facets ADHD, enabling Our findings suggest ADHD-related emerge early persist through stages. underscore need refine conceptions about neural peculiarities adapt clinical interventions targeting accordingly.

Language: Английский

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Enhancing perceptual, attentional, and working memory demands through variable practice schedules: insights from high-density EEG multi-scale analyses

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(11)

Published: Nov. 1, 2024

Abstract Contextual interference (CI) enhances learning by practicing motor tasks in a random order rather than blocked order. One hypothesis suggests that the benefits arise from enhanced early perceptual/attentional processes, while another posits better is due to highly activated mnemonic processes. We used high-density electroencephalography multi-scale analysis approach, including topographic analyses, source estimations, and functional connectivity, examine intertwined dynamics of attentional processes within short time windows. recorded scalp activity 35 participants as they performed an aiming task at three different distances, under both conditions using crossover design. Our results showed topographies associated with related perception/attention (N1, P3a) working memory (P3b) were more pronounced condition. Source estimation analyses supported these findings, revealing greater involvement perceptual ventral pathway, anterior cingulate parietal cortices, along increased connectivity alpha frontoparietal theta band networks during practice. suggest CI driven, compared condition, specific such perceptual, attentional, well large-scale sustaining general executive

Language: Английский

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Enhancing Perceptual, Attentional, and Working Memory Demands through Variable Practice Schedules: Insights from High-Density EEG Multi-Scale Analyses

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Contextual interference (CI) enhances learning by practicing motor tasks in a random order rather than blocked order. One hypothesis suggests that the benefits arise from enhanced early perceptual/attentional processes, while another posits better is due to highly activated mnemonic processes. We propose harness high-density electroencephalography multi-scale analysis approach, including topographic analyses, source estimations, and functional connectivity, examine intertwined dynamics of attentional processes within short time windows. recorded scalp activity 35 participants as they performed an aiming task at three different distances, under both conditions using crossover design. Our results showed topographies associated with related perception/attention (N1, P3a) working memory (P3b) were more pronounced condition. Source estimation analyses supported these findings, revealing greater involvement perceptual ventral pathway anterior cingulate parietal cortices, along increased connectivity alpha frontoparietal theta band networks during practice. suggest CI driven, compared condition, specific such perceptual, attentional, mnemonic, well large-scale general

Language: Английский

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Effects of Frontal-Midline Theta Neurofeedback with Different Training Directions on Goal-Directed Attentional Control

Applied Psychophysiology and Biofeedback, Journal Year: 2024, Volume and Issue: 50(1), P. 11 - 23

Published: Nov. 5, 2024

Language: Английский

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