Design of an Experimental System for the Assessment of the Drug Loss in Drug-Coated Balloons Due to Washing Off During Tracking

Designs, Journal Year: 2025, Volume and Issue: 9(2), P. 37 - 37

Published: March 24, 2025

Drug-coated balloons (DCBs) are designed to deliver an anti-proliferative drug the stenotic vessel combat restenosis after angioplasty treatment. However, significant loss can occur during device navigation toward lesion site, thus reducing delivery efficiency and increasing off-target loss. In this framework, study aimed design a novel in vitro setup estimate due blood flow–coating interaction tracking. The system consists of millifluidic chamber, able host small drug-coated flat patches representative DCBs, connected at inlet syringe pump provide ad hoc flow and, outlet, vial collecting testing fluid with possible removed from specimen. Unlike other studies, presented here uniquely evaluates flow-related smaller-scale DCB samples, making it precise, easy-to-use, efficient assessment tool. order define proper boundary conditions for these washing off tests, computational dynamics (CFD) models idealized were developed wall shear stresses (WSSs) experienced vivo by when inserted into leg arteries. From simulations, different target WSSs identified as interest be replicated setup. A combined analytical–CFD approach was followed set rates imposed generate desired WSSs. Finally, proof-of-concept performed eight coated specimens analyzing content via high-performance liquid chromatography (HPLC). Results indicated amounts according confirmed suitability assess resistance coatings balloons.

Language: Английский

A novel strategy to produce spherical SBA-15 by polymeric macrospheres as a template for drug delivery

Journal of Porous Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Mesoporous silica SBA-15 has been a material widely studied for drug delivery due to its high biocompatibility and chemical stability, ordered mesoporous cavities allow loading. However, it non-spherical particle shape, making difficult use in solid dosage forms, where spherical particles are preferred better flow distribution. In this regard, study presented novel strategy produce spheric using polymeric macrospheres of pharmaceutical grade acidic-resistant copolymer (Eudragit ® S) stabilized with Pluronic 123, as template. The Eudragit S were fabricated the double emulsion (W1/O/W2) solvent-diffusion technique then used template synthesize following acidic hydrolysis. physicochemical analysis revealed that morphology (SEM) pores arranged hexagonal lattice (TEM). XRD showed signals at 0.71, 0.88 y 2.03 °2θ, indexed Miller indices (100), (110), (200). Nitrogen adsorption-desorption isotherms (type IV, H3) demonstrated characteristics pore size 9.3 nm, wall thickness 3 volume 0.7538 cm³g −1 , surface area 640 m²g . These also zero-order release ibuprofen. formation suggests P123 on macrosphere acts core, shown by FT-IR analysis. acid-resistant maintained integrity, enabling assembly mesostructure 24-hour manufacturing time under conditions.

Language: Английский

Comparative Analysis of Bare and Quercetin-Loaded Nonionic Block Copolymer Micelles in an Artificial Gastrointestinal Medium

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Block copolymer micelles have been increasingly used for the solubilization and delivery of hydrophobic drugs. There exists a possibility dissociation formation other association structures in contact with gastrointestinal fluid. In this study, we demonstrated effect fed-state intestinal fluid (FeSSIF) upon characteristics bare quercetin (QCT)-loaded pluronic 123 (P123) micelles. Characterizations were performed using dynamic light scattering (DLS),

Language: Английский