“Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems” DOI
Sudharshan Reddy Dachani, Ankur Vashi, Anand B. Mundada

et al.

Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 16, 2024

Polymers have become a versatile tool in pharmaceutical chemistry through techniques and new formulation. This review presents an overview of the general topic drug delivery polymers, places particular focus on their specific contributions, discusses significant issues like biocompatibility, controlled release targeted delivery. Unlike previous reviews, it captures recent development biodegradable, smart stimuli-responsive abilities to improve therapy outcomes patient adherence treatments. Furthermore, this work also has enhanced understanding advanced polymer-based systems such as polymeric nanoparticles, bioconjugation strategies natural with examples various therapeutic areas. The stands for itself by expanding discussion regulatory clinical realism difficulties well safety, efficacy, acceptance considerations. In addition, emphasizes role interdisciplinary intersectoral cooperation cross-country collaborations developing polymers-based applications precision medicine. way, provides fresh view both present advancements future possibilities technologies dedicated achievements globally inspire researchers practitioners.

Language: Английский

Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review DOI Creative Commons
Mohamed T. El‐Saadony, Guihong Fang, Si Yan

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12889 - 12937

Published: Dec. 1, 2024

Abstract: Over the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, drug/gene delivery. Among these, zinc (ZnO) NPs stand out versatility effectiveness. Recently, ZnO become a primary material various sectors, such as pharmaceutical, cosmetic, antimicrobials, construction, textile, automotive industries. can generate reactive oxygen species induce cellular apoptosis, thus underpinning potent anticancer antibacterial properties. To meet growing demand, numerous synthetic approaches been developed produce NPs. However, traditional manufacturing processes often involve economic environmental costs, prompting search more sustainable alternatives. Intriguingly, synthesis methods utilizing plants, plant extracts, or microorganisms emerged ideal producing These green production techniques offer medicinal, economic, environmental, health benefits. This review highlights latest advancements applications, showcasing potential revolutionize field with eco-friendly cost-effective solutions. Keywords: antimicrobial, antioxidant, synthesis, nanomedicine, nanoparticle,

Language: Английский

Citations

9
Advances in nano drug delivery systems for enhanced efficacy of emodin in cancer therapy DOI Creative Commons

Zhenghao Ai,

Bingyao Liu, Junyan Chen

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 9, P. 100314 - 100314

Published: Dec. 25, 2024

Cancer remains one of the leading causes death worldwide, highlighting urgent need for novel antitumor drugs. Natural products have long been a crucial source anticancer agents. Among these, emodin (EMO), multifunctional anthraquinone compound, exhibits significant effects but is hindered in clinical applications by challenges such as low solubility, rapid metabolism, poor bioavailability, and off-target toxicity. Nano drug delivery systems offer effective strategies to overcome these limitations enhancing stability, targeting ability EMO. While substantial progress has made developing EMO-loaded nanoformulations, comprehensive review on this topic still lacking. This paper aims fill gap providing an overview recent advancements nanocarriers EMO their applications. These carriers include liposomes, nanoparticles, polymeric micelles, nanogels, others, with nanoparticle-based formulations being most extensively explored. Nanoformulations encapsulating demonstrated promising therapeutic results against various cancers, particularly breast cancer, followed liver lung cancers. We systematically summarize preparation methods, materials, physicochemical properties nanopreparations, underscoring key findings how nanotechnology improves efficacy provides valuable insights researchers engaged nano

Language: Английский

Citations

4
RGD peptide-functionalized micelles loaded with crocetin ameliorate doxorubicin-induced cardiotoxicity DOI Creative Commons
Ting Wang, Zhimin Li, Jian Lei

et al.

International Journal of Pharmaceutics X, Journal Year: 2025, Volume and Issue: 9, P. 100326 - 100326

Published: Feb. 26, 2025

Language: Английский

Citations

0
Microparticles zerumbone from Zingiber zerumbet rhizome in chitosan modified oleic acid DOI
Nasib Marbun,

Fardhan Roiza,

Muhammad Muttaqin

et al.

Pure and Applied Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Zerumbone is a marker compound of Zingiber zerumbet that has antioxidant and anticancer properties. It exhibits low solubility in water, necessitating methods to enhance it solubility, such as the creation microparticles with chitosan oleic acid. Therefore, this research aimed isolate zerumbone from Z. rhizome determine formation its isolated by recrystallization essential oil. Six different formulations (2.5–3.0 %), TPP cross-linker, acid surfactant, zerumbone. The was analyzed using FTIR. results showed yield 0.11 % decibels. particle size best microparticle 5.516 μm, absorptive efficiency 47 %, amide linkages between were confirmed based on have LC 50 value lower than native chitosan-modified great potential for delivery.

Language: Английский

Citations

0
Polymeric Nanosystems: A Breakthrough Approach to Treating Inflammation and Inflammation Related Diseases DOI Open Access
Maja D. Marković, Vesna V. Panić, Rada Pjanović

et al.

Biopolymers, Journal Year: 2025, Volume and Issue: 116(3)

Published: March 19, 2025

ABSTRACT Inflammation processes can cause mild to severe damage in the human body and lead a large number of inflammation‐related diseases (IRD) such as cancer, neural, vascular, pulmonary diseases. Limitations anti‐inflammatory drugs (AID) application are reflected high therapeutic doses, toxicity, low bioavailability solubility, side effects, etc. Polymeric nanosystems (PS) have been recognized safe effective technology that is able overcome these limitations by AID encapsulation answer specific demands IRD treatment. PS attracting great attention due their versatility, biocompatibility, fine‐tuned properties, functionality, ability for precise delivery targeted sites body. This article offers an overview three classes polymeric nanosystems: a) dendrimers, b) micelles nanoparticles, c) filomicelles, well preparation, In future, formulations clinical practice will certainly increase.

Language: Английский

Citations

0
Emerging trends in chitosan based colloidal drug delivery systems: A translational journey from research to practice DOI
Murli Manohar,

Amitha Shetty,

Cynthia Lizzie Lobo

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123604 - 123604

Published: April 1, 2025

Language: Английский

Citations

0
“Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems” DOI
Sudharshan Reddy Dachani, Ankur Vashi, Anand B. Mundada

et al.

Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 16, 2024

Polymers have become a versatile tool in pharmaceutical chemistry through techniques and new formulation. This review presents an overview of the general topic drug delivery polymers, places particular focus on their specific contributions, discusses significant issues like biocompatibility, controlled release targeted delivery. Unlike previous reviews, it captures recent development biodegradable, smart stimuli-responsive abilities to improve therapy outcomes patient adherence treatments. Furthermore, this work also has enhanced understanding advanced polymer-based systems such as polymeric nanoparticles, bioconjugation strategies natural with examples various therapeutic areas. The stands for itself by expanding discussion regulatory clinical realism difficulties well safety, efficacy, acceptance considerations. In addition, emphasizes role interdisciplinary intersectoral cooperation cross-country collaborations developing polymers-based applications precision medicine. way, provides fresh view both present advancements future possibilities technologies dedicated achievements globally inspire researchers practitioners.

Language: Английский

Citations

2