Investigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia DOI Creative Commons
Spiros Vlahopoulos, Lokman Varışlı,

Panagiotis Zoumpourlis

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 65(6)

Published: Oct. 30, 2024

Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a of the aldehyde gene subfamily that encode enzymes with ability to oxidize retinaldehyde. It was recently shown high ALDH1A1 RNA abundance correlates poor prognosis in acute myeloid leukemia (AML). AML hematopoietic malignancy associated morbidity and mortality rates. Although there are number agents inhibit ALDH activity, it would be crucial develop methodologies for adjustable genetic interference, which permit interventions on several oncogenic pathways parallel. Intervention multiple theoretically possible microRNAs (miRNAs or miRs), class small non‑coding RNAs have emerged as key regulators expression AML. A miRNAs interfere directly solid tumor cells, these can evaluated model systems. There indications few actually do an association disease course, rendering them promising target intervention cells.

Language: Английский

Pulmonary fibrosis: from mechanisms to therapies DOI Creative Commons

Mengna Jiang,

Wenxia Bu,

Xuehai Wang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 8, 2025

Pulmonary fibrosis (PF) is a chronic, progressive interstitial lung disease characterized by excessive deposition of extracellular matrix (ECM) and abnormal fibroblast proliferation, which mainly caused air pollution, smoking, aging, occupational exposure, environmental pollutants microbial infections. Although antifibrotic agents such as pirfenidone nintedanib, approved the United States (US) Food Drug Administration (FDA), can slow decline in function progression, their side effects delivery inefficiency limit overall prognosis PF. Therefore, there an urgent need to develop effective therapeutic targets approaches for PF clinical settings. This review provides overview pathogenic mechanisms, drug targeting signaling pathways, promising strategies treating

Language: Английский

Citations

0
Investigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia DOI Creative Commons
Spiros Vlahopoulos, Lokman Varışlı,

Panagiotis Zoumpourlis

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 65(6)

Published: Oct. 30, 2024

Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a of the aldehyde gene subfamily that encode enzymes with ability to oxidize retinaldehyde. It was recently shown high ALDH1A1 RNA abundance correlates poor prognosis in acute myeloid leukemia (AML). AML hematopoietic malignancy associated morbidity and mortality rates. Although there are number agents inhibit ALDH activity, it would be crucial develop methodologies for adjustable genetic interference, which permit interventions on several oncogenic pathways parallel. Intervention multiple theoretically possible microRNAs (miRNAs or miRs), class small non‑coding RNAs have emerged as key regulators expression AML. A miRNAs interfere directly solid tumor cells, these can evaluated model systems. There indications few actually do an association disease course, rendering them promising target intervention cells.

Language: Английский

Citations

0