Melatonin as a natural ally against oxidative stress: a physicochemical examination

Journal of Pineal Research, Journal Year: 2011, Volume and Issue: 51(1), P. 1 - 16

Published: June 14, 2011

Abstract: Oxidative stress has been proven to be related the onset of a large number health disorders. This chemical is triggered by an excess free radicals, which are generated in cells because wide variety exogenous and endogenous processes. Therefore, finding strategies for efficiently detoxifying radicals become subject great interest, from both academic practical points view. Melatonin ubiquitous versatile molecule that exhibits most desirable characteristics good antioxidant. The amount data gathered so far regarding protective action melatonin against oxidative overwhelming. However, rather little known concerning mechanisms involved this activity. review summarizes current progress understanding physicochemical insights radical–scavenging activity melatonin. Thus far, there general agreement electron transfer hydrogen main reactions with radicals. relative importance other also analyzed. nature reacting radical influence on different these reactions. point discussed detail review. Based available data, it concluded protects mechanisms. Moreover, proposed even though referred as expression darkness, perhaps could light health.

Language: Английский

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Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Endocrine, Journal Year: 2005, Volume and Issue: 27(2), P. 119 - 130

Published: Jan. 1, 2005

Language: Английский

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Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

Critical Reviews in Biochemistry and Molecular Biology, Journal Year: 2009, Volume and Issue: 44(4), P. 175 - 200

Published: July 6, 2009

The discovery of melatonin and its derivatives as antioxidants has stimulated a very large number studies which have, virtually uniformly, documented the ability these molecules to detoxify harmful reactants reduce molecular damage. These observations have clear clinical implications given that numerous age-related diseases in humans an important free radical component. Moreover, major theory explain processes aging invokes radicals their causative agents. conditions, coupled with loss organisms age, suggest some aspects may be aggravated by diminished levels advanced age. Another corollary this is administration melatonin, uncommonly low toxicity profile, could theoretically defer progression possibly forestall signs aging. Certainly, research next decade will help define role determining successful While increasing life span not necessarily goal investigative efforts, improving health quality aged should aim research.

Language: Английский

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Free Radical Properties, Source and Targets, Antioxidant Consumption and Health

Oxygen, Journal Year: 2022, Volume and Issue: 2(2), P. 48 - 78

Published: April 12, 2022

Free radicals have acquired growing importance in the fields of biology and medicine. They are produced during many different endogenous exogenous processes. Mitochondria main source reactive oxygen species (ROS) at cell level. The overproduction free can damage macromolecules such as nucleic acids, proteins lipids. This leads to tissue various chronic degenerative diseases. Antioxidants play a crucial role body’s defense against radicals. review concerns properties radicals, their sources deleterious effects. It highlights potential dietary supplementation antioxidants discusses unsolved problems regarding antioxidant supplements prevention therapy

Language: Английский

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Trends in the development of radioprotective agents

Drug Discovery Today, Journal Year: 2007, Volume and Issue: 12(19-20), P. 794 - 805

Published: Sept. 11, 2007

Language: Английский

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Melatonin and the ovary: physiological and pathophysiological implications

Fertility and Sterility, Journal Year: 2008, Volume and Issue: 92(1), P. 328 - 343

Published: Sept. 19, 2008

Language: Английский

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Radiation pneumonitis and pulmonary fibrosis in non–small-cell lung cancer: Pulmonary function, prediction, and prevention

International Journal of Radiation Oncology*Biology*Physics, Journal Year: 2005, Volume and Issue: 63(1), P. 5 - 24

Published: June 18, 2005

Language: Английский

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Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

International Journal of Molecular Sciences, Journal Year: 2017, Volume and Issue: 18(4), P. 843 - 843

Published: April 17, 2017

There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, molecular mechanisms underpinning these inhibitory actions have been proposed. What rather perplexing, however, large number of processes by which reportedly restrains development growth. These diverse suggest what being observed are merely epiphenomena an underlying more fundamental action remains to be disclosed. Some arresting on clearly membrane receptor-mediated while others receptor-independent involve direct intracellular this ubiquitously-distributed molecule. While emphasis melatonin/cancer research has role indoleamine in restraining breast cancer, changing quickly with types having shown susceptible inhibition melatonin. several facets could immediate applications clinical level. Many studies melatonin's co-administration improves sensitivity cancers conventional drugs. Even important findings renders previously totally resistant treatment sensitive same therapies. Melatonin also inhibits associated limiting entrance cells into vascular system preventing them from establishing secondary growths distant sites. This particular importance since often significantly contributes death patient. Another area deserves additional consideration related capacity reducing toxic consequences anti-cancer drugs increasing their efficacy. Although information available for than a decade, it not adequately exploited if only beneficial patients its ability attenuate acute long-term drug toxicity, should used improve physical wellbeing patients. The experimental findings, advantages using as co-treatment therapies would far exceed improvements

Language: Английский

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Food Antioxidants: Chemical Insights at the Molecular Level

Annual Review of Food Science and Technology, Journal Year: 2016, Volume and Issue: 7(1), P. 335 - 352

Published: Jan. 16, 2016

In this review, we briefly summarize the reliability of density functional theory (DFT)-based methods to accurately predict main antioxidant properties and reaction mechanisms involved in free radical-scavenging reactions chemical compounds present food. The analyzed are bond dissociation energies, particular those involving OH bonds, electron transfer enthalpies, adiabatic ionization potentials, proton affinities. hydrogen-atom transfer, proton-coupled radical adduct formation, single sequential proton-loss transfer. Furthermore, chelating ability these its role decreasing or inhibiting oxidative stress induced by Fe(III) Cu(II) considered. Comparisons between theoretical experimental data confirm that modern tools not only able explain controversial facts but also behavior.

Language: Английский

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Recent advances in hydrogen research as a therapeutic medical gas

Free Radical Research, Journal Year: 2010, Volume and Issue: 44(9), P. 971 - 982

Published: Sept. 1, 2010

Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory anti-apoptotic protective effects on cells organs. Therapeutic been applied by different delivery methods including straightforward inhalation, drinking dissolved in water injection hydrogen-saturated saline. This review summarizes currently available data regarding the role of hydrogen, provides outline recent advances use as a therapeutic medical gas diverse models disease discusses feasibility strategy. It not overstatement to say hydrogen's impact preventive medicine could be enormous future.

Language: Английский

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