Physics and Imaging in Radiation Oncology,
Journal Year:
2020,
Volume and Issue:
16, P. 54 - 60
Published: Oct. 1, 2020
Background
and
purposeAuto-contouring
performance
has
been
widely
studied
in
development
commissioning
studies
radiotherapy,
its
impact
on
clinical
workflow
assessed
that
context.
This
study
aimed
to
evaluate
the
manual
adjustment
of
auto-contouring
routine
practice
identify
improvements
regarding
model
user
interaction,
improve
efficiency
auto-contouring.Materials
methodsA
total
103
head
neck
cancer
cases,
contoured
using
a
commercial
deep-learning
contouring
system
subsequently
checked
edited
for
use
were
retrospectively
taken
from
data
over
twelve-month
period
(April
2019–April
2020).
The
amount
performed
was
calculated,
all
cases
registered
common
reference
frame
assessment
purposes.
median,
10th
90th
percentile
calculated
displayed
3D
renderings
structures
visually
assess
systematic
random
adjustment.
Results
also
compared
inter-observer
variation
reported
previously.
Assessment
both
whole
regional
sub-structures,
according
radiation
therapy
technologist
(RTT)
who
contour.ResultsThe
median
low
(<2
mm),
although
large
local
observed
some
structures.
systematically
greater
or
equal
zero,
indicating
tends
under-segment
desired
contour.ConclusionAuto-contouring
identified
required
technically,
but
highlighted
need
continued
RTT
training
ensure
adherence
guidelines.
Radiation Oncology,
Journal Year:
2020,
Volume and Issue:
15(1)
Published: May 6, 2020
Abstract
Background
Automated
brain
tumor
segmentation
methods
are
computational
algorithms
that
yield
delineation
from,
in
this
case,
multimodal
magnetic
resonance
imaging
(MRI).
We
present
an
automated
method
and
its
results
for
resection
cavity
(RC)
glioblastoma
multiforme
(GBM)
patients
using
deep
learning
(DL)
technologies.
Methods
Post-operative,
T1w
with
without
contrast,
T2w
fluid
attenuated
inversion
recovery
MRI
studies
of
30
GBM
were
included.
Three
radiation
oncologists
manually
delineated
the
RC
to
obtain
a
reference
segmentation.
developed
DL
method,
which
utilizes
all
four
sequences
learn
perform
delineations.
evaluated
terms
Dice
coefficient
(DC)
estimated
volume
measurements.
Results
Median
DC
three
oncologist
0.85
(interquartile
range
[IQR]:
0.08),
0.84
(IQR:
0.07),
0.86
0.07).
The
automatic
compared
different
raters
0.83
0.14),
0.81
0.12),
0.13)
was
significantly
lower
among
(chi-square
=
11.63,
p
0.04).
did
not
detect
statistically
significant
difference
measured
volumes
(Kruskal-Wallis
test:
chi-square
1.46,
0.69).
main
sources
error
due
signal
inhomogeneity
similar
intensity
patterns
between
tissues.
Conclusions
proposed
approach
yields
promising
proof
concept
study.
Compared
human
experts,
still
subpar.
PeerJ,
Journal Year:
2021,
Volume and Issue:
9, P. e11451 - e11451
Published: May 17, 2021
Artificial
intelligence
has
been
emerging
as
an
increasingly
important
aspect
of
our
daily
lives
and
is
widely
applied
in
medical
science.
One
major
application
artificial
science
imaging.
As
a
component
intelligence,
many
machine
learning
models
are
diagnosis
treatment
with
the
advancement
technology
imaging
facilities.
The
popularity
convolutional
neural
network
dental,
oral
craniofacial
heightening,
it
continually
to
broader
spectrum
scientific
studies.
Our
manuscript
reviews
fundamental
principles
rationales
behind
learning,
summarizes
its
research
progress
recent
applications
specifically
It
also
problems
that
remain
be
resolved
evaluates
prospect
future
development
this
field
study.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: April 6, 2023
Organ-at-risk
segmentation
for
head
and
neck
cancer
radiation
therapy
is
a
complex
time-consuming
process
(requiring
up
to
42
individual
structure,
may
delay
start
of
treatment
or
even
limit
access
function-preserving
care.
Feasibility
using
deep
learning
(DL)
based
autosegmentation
model
reduce
contouring
time
without
compromising
contour
accuracy
assessed
through
blinded
randomized
trial
oncologists
(ROs)
retrospective,
de-identified
patient
data.
Physics and Imaging in Radiation Oncology,
Journal Year:
2020,
Volume and Issue:
15, P. 8 - 15
Published: July 1, 2020
Background
and
purposeHead
neck
(HN)
radiotherapy
can
benefit
from
automatic
delineation
of
tumor
surrounding
organs
because
the
complex
anatomy
regular
need
for
adaptation.
The
aim
this
study
was
to
assess
performance
a
commercially
available
deep
learning
contouring
(DLC)
model
on
an
external
validation
set.Materials
methodsThe
CT-based
DLC
model,
trained
at
University
Medical
Center
Groningen
(UMCG),
applied
independent
set
58
patients
Radboud
(RUMC).
results
were
compared
RUMC
manual
reference
using
Dice
similarity
coefficient
(DSC)
95th
percentile
Hausdorff
distance
(HD95).
Craniocaudal
spatial
information
added
by
calculating
binned
measures.
In
addition,
qualitative
evaluation
acceptance
contours
in
both
groups
observers.ResultsGood
correspondence
shown
mandible
(DSC
0.90;
HD95
3.6
mm).
Performance
reasonable
glandular
OARs,
brainstem
oral
cavity
0.78–0.85,
3.7–7.3
other
aerodigestive
tract
OARs
showed
only
moderate
agreement
0.53–0.65,
around
9
measures
displayed
largest
deviations
caudally
and/or
cranially.ConclusionsThis
demonstrates
that
provide
starting
point
when
patient
cohort.
did
not
reveal
large
differences
interpretation
guidelines
between
UMCG
observers.
Medical Physics,
Journal Year:
2021,
Volume and Issue:
48(7), P. 3968 - 3981
Published: April 27, 2021
Purpose
Accurately
delineating
clinical
target
volumes
(CTV)
is
essential
for
completing
radiotherapy
plans
but
time‐consuming,
labor‐intensive,
and
prone
to
inter‐observer
variation.
Automating
CTV
delineation
has
the
benefits
of
both
speeding
up
contouring
process
improving
quality
contours.
Recently,
auto‐segmentation
approaches
based
on
deep
learning
have
achieved
some
improvements.
However,
unlike
organ
segmentation,
contains
potential
tumor
spread
tissues
or
subclinical
disease
tissues,
resulting
in
poorly
defined
margin
interface
irregular
shape.
It
not
reasonable
directly
apply
segmentation
algorithms
tasks
without
considering
unique
characteristics
shape
margin.
In
this
work,
we
propose
a
novel
automatic
algorithm
addressing
challenges.
Methods
Our
method,
called
RA‐CTVNet,
segments
from
cervical
cancer
CT
images.
RA‐CTVNet
denotes
our
with
A
rea‐aware
reweight
strategy
R
ecursive
refinement
strategy.
(1)
order
whole‐volume
images
delineate
all
CTVs
one
shot,
method
built
upon
popular
3D
Unet
architecture.
We
further
extend
it
robust
residual
squeeze‐and‐excitation
blocks
better
feature
representation.
(2)
area‐aware
which
assigns
different
weights
slices.
The
core
adjusting
model’s
attention
each
slice.
(3)
terms
trade‐off
between
providing
performance
improvements
meeting
limitations
GPU
memory,
exploit
new
recursive
address
challenge.
Results
This
retrospective
study
included
462
patients
diagnosed
who
received
June
2017
May
2019.
Extensive
experiments
were
conducted
evaluate
RA‐CTVNet.
First,
compared
network
architectures,
Dice
similarity
coefficient
(DSC).
Second,
ablation
study.
results
showed
that
backbone,
increased
DSC
by
3.3%
average
1.6%
average.
Then,
three
human
experts.
performed
than
two
experts
while
comparably
third
expert.
Finally,
multicenter
evaluation
was
verify
accuracy
generalizability.
Conclusions
findings
show
able
offer
an
efficient
framework
delineation.
tailored
can
improve
contours,
great
reducing
burden
increasing
future,
if
more
training
data,
are
possible,
bringing
approach
closer
real
practice.
Magnetic Resonance in Medicine,
Journal Year:
2022,
Volume and Issue:
88(6), P. 2592 - 2608
Published: Sept. 21, 2022
Abstract
Radiation
therapy
is
a
major
component
of
cancer
treatment
pathways
worldwide.
The
main
aim
this
to
achieve
tumor
control
through
the
delivery
ionizing
radiation
while
preserving
healthy
tissues
for
minimal
toxicity.
Because
relies
on
accurate
localization
target
and
surrounding
tissues,
imaging
plays
crucial
role
throughout
chain.
In
planning
phase,
radiological
images
are
essential
defining
volumes
organs‐at‐risk,
as
well
providing
elemental
composition
(e.g.,
electron
density)
information
dose
calculations.
At
treatment,
onboard
informs
patient
setup
could
be
used
guide
placement
sites
affected
by
motion.
Imaging
also
an
important
tool
response
assessment
plan
adaptation.
MRI,
with
its
excellent
soft
tissue
contrast
capacity
probe
functional
properties,
holds
great
untapped
potential
transforming
paradigms
in
therapy.
MR
Therapy
ISMRM
Study
Group
was
established
provide
forum
within
community
discuss
unmet
needs
fuel
opportunities
further
advancement
MRI
applications.
During
summer
2021,
study
group
organized
first
virtual
workshop,
attended
diverse
international
clinicians,
scientists,
clinical
physicists,
explore
our
predictions
future
next
25
years.
This
article
reviews
findings
from
event
considers
challenges
reaching
vision
expanding
field.
Physics in Medicine and Biology,
Journal Year:
2022,
Volume and Issue:
67(11), P. 115007 - 115007
Published: Feb. 8, 2022
Purpose.The
purpose
of
this
study
was
to
utilize
a
deep
learning
model
with
an
advanced
inception
module
automatically
contour
critical
organs
on
the
computed
tomography
(CT)
scans
head
and
neck
cancer
patients
who
underwent
radiation
therapy
treatment
interpret
clinical
suitability
results
through
activation
mapping.Materials
methods.This
included
25
that
were
delineated
by
expert
oncologists.
Contoured
medical
images
964
sourced
from
publicly
available
TCIA
database.
The
proportion
training,
validation,
testing
samples
for
development
65%,
25%,
10%
respectively.
CT
segmentation
masks
augmented
shift,
scale,
rotate
transformations.
Additionally,
pre-processed
using
contrast
limited
adaptive
histogram
equalization
enhance
soft
tissue
while
contours
subjected
morphological
operations
ensure
their
structural
integrity.
based
U-Net
architecture
embedded
Inception-ResNet-v2
blocks
trained
over
100
epochs
batch
size
32
rate
optimizer.
loss
function
combined
Jaccard
Index
binary
cross
entropy.
performance
evaluated
Dice
Score,
Index,
Hausdorff
Distances.
interpretability
analyzed
guided
gradient-weighted
class
mapping.Results.The
mean
Distance
averaged
all
structures
0.82
±
0.10,
0.71
1.51
1.17
mm
respectively
data
sets.
Scores
86.4%
compared
within
range
or
better
than
published
interobserver
variability
derived
multi-institutional
studies.
average
training
time
8
h
per
anatomical
structure.
full
anatomy
network
required
only
6.8
s
patient.Conclusions.High
accuracy
obtained
large,
set,
short
clinically-realistic
prediction
reasoning
make
proposed
in
work
feasible
solution
scan
environment.