Role of ferroptosis in the occurrence and progression of acute ischemic stroke DOI Open Access
H Li, Bin Meng,

Zhongqiang Cheng

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: June 8, 2023

Ferroptosis is a new non-apoptotic form of regulatory cell death, which characterized by intracellular iron overload and excessive accumulation lipid peroxides reactive oxygen species (ROS). closely related to iron, amino acid, metabolism disorders. increasingly recognized as an important process mediating the pathogenesis progression acute ischemic stroke, it can be involved in influencing stroke risk factors atherosclerosis, atrial fibrillation, hypertension, diabetes mellitus, obstructive sleep apnea. Therefore, understanding mechanisms ferroptosis regulation different diseases may have significant implications for preventive treatment improvement prognosis patients with stroke. This article reviews not only specific development but also relevant associations between ferroptosis, describes current limitations future directions its factors.

Language: Английский

Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 DOI Creative Commons
Dandan Liu,

Hewei Qin,

Guanghua Liu

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 126, P. 106695 - 106695

Published: Feb. 5, 2025

Language: Английский

Citations

0
Ferroptosis, pathogenesis and therapy in AS co-depression disease DOI Creative Commons

Yulong Zhao,

Peng Ren,

Qiang Luo

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

Atherosclerosis (AS)-related cardiovascular disease and depression are often comorbid, with patients facing an increased risk of depression, which worsens AS. Both diseases characterized by oxidative stress lipid metabolism disorders. Ferroptosis, a form cell death iron overload harmful peroxide accumulation, is found in various diseases, including AS depression. Consistent the deposition peroxidation (LPO) that characterize ferroptosis mechanism, disturbances also crucial pathogenic mechanisms The comorbid complex, posing challenges for clinical treatment. Chinese herbs hold significant potential owing to their multi-target pharmacological effects. Therefore, this review aims investigate overload, LPO, across types, shared pathogenesis ferroptosis, research on herbal medicine targeting treatment anti-AS co-depression. This provides comprehensive understanding co-depression from perspective ferroptosis.

Language: Английский

Citations

0
p38γ modulates ferroptosis in brain injury caused by ethanol and cerebral ischemia/reperfusion by regulating the p53/SLC7A11 signaling pathway DOI Creative Commons
Xingyu Zhu, Zhihan Zhao, Yan Zhang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111728 - 111728

Published: March 1, 2025

Ischemic stroke, a neurological condition with complicated etiology that is accompanied by severe inflammation and oxidative stress, ethanol (EtOH) may aggravate ischemia/reperfusion (I/R)-induced brain damage. However, the effect of prolonged alcohol intake on acute injury remains ambiguous. As part mitogen-activated protein kinase (MAPK) family, p38γ involved in ferroptosis various diseases. This study explored how effects chronic EtOH consumption caused cerebral I/R. Brain damage was induced mice via administration liquid alcohol-containing diet for 8 weeks, middle artery occlusion reperfusion (MCAO/R), or combination both. We verified significantly exacerbated MCAO/R-induced damage, inflammation. Notably, levels were increased experimental mouse cell models. knockdown markedly attenuated tissue inflammatory infiltration + MCAO/R-treated mice. Mechanistic experiments revealed regulate through p53/SLC7A11 pathway. Overall, our results indicate crucial regulating EtOH- I/R-induced modulating

Language: Английский

Citations

0
Stroke Risk in Head and Neck Cancer: A Meta‐analysis of Reconstructed Individual Patient Survival Data DOI

Elaine Chiew-Lin Liew,

Jennifer Tan,

Chen Ee Low

et al.

Otolaryngology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Objective Although previous studies suggest an increased stroke risk in head and neck cancer (HNC) survivors, the with various treatment modalities, including radiotherapy, is less certain. This study investigates incidence HNC patients, how different treatments influence risk. Data Sources A literature search of PubMed, Scopus, Embase was conducted. Review Methods We included all primary assessing as outcome patients aged 18 older, regardless subtype or modality. Incidence rates were pooled by reconstructing individual patient time‐to‐event data from survival curves. Random‐effects meta‐analyses employed to compare between healthy controls, groups. Results In total, 15 (N = 2,295,447 patients) analyses. Among surviving occurred at a rate 1% per year (10% 10 years 15% cumulatively). Meta‐analyses showed that had significantly higher compared controls (hazard ratio [HR] 1.45; 95% CI: 1.27‐1.65; I 2 : 20%). radiotherapy alone surgery (HR 1.66; 1.35‐2.03; 0%). Patients who received any form those without 1.47; 1.29‐1.68; 60%). definitive chemoradiotherapy heightened 1.28; 1.09‐1.49; 86%). Conclusion face elevated risk, especially treated radiotherapy. underscores need for surveillance tailored preventive strategies reduce this vulnerable population.

Language: Английский

Citations

0
Role of ferroptosis in radiation-induced soft tissue injury DOI Creative Commons

Charlotte E. Berry,

Carter B. Kendig,

Nicholas An

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: July 5, 2024

Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage the generation of reactive oxygen species, which harm nucleic acids, lipids, proteins. While cells are more vulnerable ionizing their inefficiency repairing damage, healthy irradiated area also suffer. Various types cell death occur, including apoptosis, necrosis, pyroptosis, autophagy-dependent death, immunogenic ferroptosis. Ferroptosis, driven by iron-dependent lipid peroxide accumulation, recognized as crucial therapy's effects complications, with extensive research across various tissues. This review aims summarize pathways involved radiation-related ferroptosis, findings different organs, drugs targeting ferroptosis mitigate harmful effects.

Language: Английский

Citations

3
Targeting Ferroptosis: A Novel Strategy for the Treatment of Atherosclerosis DOI
Yifan Zhang, Cheng‐Shi Jiang, Ning Meng

et al.

Mini-Reviews in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(13), P. 1262 - 1276

Published: Jan. 29, 2024

Since ferroptosis was reported in 2012, its application prospects various diseases have been widely considered, initially as a treatment direction for tumors. Recent studies shown that is closely related to the occurrence and development of atherosclerosis. The primary mechanism affect atherosclerosis through intracellular iron homeostasis, ROS lipid peroxide production metabolism, variety signaling pathways. Inhibition effective inhibiting atherosclerosis, it can bring new treating In this review, we discuss focus on relationship between summarize different types inhibitors studied, some issues worthy attention by targeting ferroptosis.

Language: Английский

Citations

2
Reparative effects after low-dose radiation exposure: Inhibition of atherosclerosis by reducing NETs release DOI Creative Commons

Shugen Qu,

Xu Qiu,

Jiao Liu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 947, P. 174540 - 174540

Published: July 6, 2024

The cardiovascular system effects of environmental low-dose radiation exposure on practitioners remain uncertain and require further investigation. aim this study was to initially investigate explore the mechanisms by which may contribute atherosclerosis through a multi-omics joint comprehensive basic experiment.

Language: Английский

Citations

2
Carotid Artery Stenosis and Ischemic Stroke in Patients With Head and Neck Cancer Treated With Radiation Therapy: A Critical Review DOI
Justin Smith, Danielle N. Margalit, Jonathan Golledge

et al.

International Journal of Radiation Oncology*Biology*Physics, Journal Year: 2024, Volume and Issue: 119(5), P. 1437 - 1454

Published: April 5, 2024

Language: Английский

Citations

1
Iron and atherosclerosis: Lessons learned from rabbits relevant to human disease DOI
Barry Halliwell, F. Watt,

Ren Minqin

et al.

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 209, P. 165 - 170

Published: Oct. 16, 2023

Language: Английский

Citations

2
Radiation-Induced Endothelial Ferroptosis Accelerates Atherosclerosis via the DDHD2-Mediated Nrf2/GPX4 Pathway DOI Creative Commons

Xi Su,

Feng Liang,

Ya Zeng

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 879 - 879

Published: July 22, 2024

This study sought to explore potential roles of endothelial ferroptosis in radiation-associated atherosclerosis (RAA) and molecular mechanisms behind this phenomenon. Here, an vivo RAA mouse model was used treated with inhibitors. We found that the group had a higher plaque burden reduction cells increased lipid peroxidation compared control group, while ameliorated by liproxstatin-1. In vitro experiments further confirmed radiation induced occurrence human artery (HAECs). Then, proteomics analysis HAECs identified domain-containing protein 2 (DDHD2) as co-differentially expressed protein, which enriched metabolism pathway. addition, level elevated DDHD2-knockdown HAECs. Mechanistically, significant decrease mRNA expression glutathione peroxidase 4 (GPX4) observed following DDHD2 knockdown. Co-immunoprecipitation assays indicated interaction between nuclear factor erythroid 2-related (Nrf2). The downregulation Nrf2 also detected conclusion, our findings suggest radiation-induced accelerates atherosclerosis, is regulatory through Nrf2/GPX4

Language: Английский

Citations

0