Impact of Periodontal Lipopolysaccharides on Systemic Health: Mechanisms, Clinical Implications, and Future Directions DOI

Wanderson Silva dos Santos,

Isabelly G. Solon, Luiz G.S. Branco

et al.

Molecular Oral Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

ABSTRACT Periodontal diseases, particularly periodontitis, are complex inflammatory conditions caused by interactions between oral microbiota and the host immune response. Lipopolysaccharides (LPSs) from Gram‐negative bacteria like Tannerella forsythia , Treponema denticola Porphyromonas gingivalis key in pathogenesis. This review examines how LPS impacts systemic health through direct invasion, compromised barriers, increased vascular permeability, cell transport. triggers inflammation periodontal tissues, leading to tissue destruction disease progression. In bloodstream, contributes conditions, such as cardiovascular diabetes, respiratory rheumatoid arthritis. Current treatments include mechanical debridement, antibiotics, antimicrobial mouthwashes, anti‐inflammatory therapies. Despite progress, gaps remain understanding molecular mechanisms of diseases. Future research should focus on longitudinal studies, gut–oral axis, biomarkers for early detection, lymphatic system's role dissemination. Maintaining is crucial overall well‐being.

Language: Английский

Efficacy of caerulomycin A in modulating macrophage polarization and cytokine response in a murine model of lipopolysaccharide-induced sepsis DOI Creative Commons
Jun Zhang,

Shiyue Tang

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 10, 2025

Sepsis is characterized by an excessive immune response. Modulation of the response, particularly macrophage polarization, may provide therapeutic benefit. The effects Caerulomycin A (caeA), a known STAT1 phosphorylation inhibitor, on polarization and inflammatory markers were explored using lipopolysaccharide (LPS)-induced sepsis mouse model. model was established in C57BL/6 mice induced intraperitoneal injection LPS, survival rate observed after treatment with different doses caeA to determine optimal dose. For in-vitro assays RAW264.7 cell line, concentration that non-toxic screened MTT assay, followed analyses qRT-PCR, ELISA, Western blot flow cytometry for M1/M2 type (CD86, NOS2, CD206, ARG1) factors (IL-1β, IL-6, TNF-α, IL-4, IL-10) expression. In addition, levels STAT6 JAK–STAT signaling pathway detected. results in-vivo experiments showed (20 mg/kg) significantly increased LPS-induced septic decreased expression M1-type (CD86 NOS2) pro-inflammatory cytokines TNF-α) while increasing M2-type (CD206 anti-inflammatory (IL-4 experiments, 20 μM effectively inhibited macrophages without affecting activity cells, yet enhanced level STAT6, as detected blot. CaeA modulates attenuates response mice, possibly pathway. These findings support further exploration potential agent sepsis.

Language: Английский

Citations

0
New formulation of ibuprofen-arginate reduces oxidative stress and prevents macrophage polarization toward M1 phenotype DOI Open Access
María Soledad Álvarez,

Luciana Mazzei,

María Belén Hapon

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117819 - 117819

Published: Jan. 21, 2025

Language: Английский

Citations

0
Exosomal miR-203 from bone marrow stem cells targets the SOCS3/NF-κB pathway to regulate neuroinflammation in temporal lobe epilepsy DOI
Wei Wang, Jian Yin

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 24, 2025

Epilepsy is a prevalent chronic neurological disorder affecting 50 million individuals globally, with temporal lobe epilepsy (TLE) being the most common form. Despite advances in antiepileptic drug development, over 30% of patients suffer from drug-resistant epilepsy, which can lead to severe cognitive impairments and adverse psychosocial outcomes. To explore role bone marrow mesenchymal stem cell (BMSC)-derived exosomal miR-203 regulation neuroinflammation mouse model providing theoretical basis for development targeted microRNA delivery therapies epilepsy. Adult male C57BL/6 mice were divided into control group TLE 30 each, was established by injecting kainic acid. BMSCs isolated mice, exosomes purified using ultracentrifugation. Exosomal identified characterized high-throughput sequencing quantitative reverse-transcription polymerase chain reaction. The uptake hippocampal neurons subsequent effects on neuroinflammatory markers assessed vitro culture models. exhibited significant upregulation derived epileptic mice. In investigations demonstrated efficient internalization these neurons, resulting downregulation suppressor cytokine signaling 3 expression activation nuclear factor kappaB pathway, ultimately leading enhanced secretion pro-inflammatory cytokines. Our study identifies as key regulator findings suggest that targeting may offer novel therapeutic strategy modulating suppression 3/nuclear thus potential avenue cell-free therapeutics.

Language: Английский

Citations

0
Combination of lipopolysaccharide and polygalacturonic acid exerts antitumor activity and augments anti-PD-L1 immunotherapy DOI
Jie Song, Jiaxin Li, Anping Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136390 - 136390

Published: Oct. 9, 2024

Language: Английский

Citations

0
The role of macrophage and adipocyte mitochondrial dysfunction in the pathogenesis of obesity DOI Creative Commons
Min Wang, Min Min,

Hongying Duan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Obesity has emerged as a prominent global public health concern, leading to the development of numerous metabolic disorders such cardiovascular diseases, type-2 diabetes mellitus (T2DM), sleep apnea and several system diseases. It is widely recognized that obesity characterized by state inflammation, with immune cells-particularly macrophages-playing significant role in its pathogenesis through production inflammatory cytokines activation corresponding pathways. In addition their functions, macrophages have also been implicated lipogenesis. Additionally, mitochondrial existed commonly, decreased heat production. Meantime, adipocytes dysfunction damage which affect thermogenesis insulin resistance. Therefore, enhancing our comprehension both adipose tissue will facilitate identification potential therapeutic targets for addressing this condition.

Language: Английский

Citations

0
Impact of Periodontal Lipopolysaccharides on Systemic Health: Mechanisms, Clinical Implications, and Future Directions DOI

Wanderson Silva dos Santos,

Isabelly G. Solon, Luiz G.S. Branco

et al.

Molecular Oral Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

ABSTRACT Periodontal diseases, particularly periodontitis, are complex inflammatory conditions caused by interactions between oral microbiota and the host immune response. Lipopolysaccharides (LPSs) from Gram‐negative bacteria like Tannerella forsythia , Treponema denticola Porphyromonas gingivalis key in pathogenesis. This review examines how LPS impacts systemic health through direct invasion, compromised barriers, increased vascular permeability, cell transport. triggers inflammation periodontal tissues, leading to tissue destruction disease progression. In bloodstream, contributes conditions, such as cardiovascular diabetes, respiratory rheumatoid arthritis. Current treatments include mechanical debridement, antibiotics, antimicrobial mouthwashes, anti‐inflammatory therapies. Despite progress, gaps remain understanding molecular mechanisms of diseases. Future research should focus on longitudinal studies, gut–oral axis, biomarkers for early detection, lymphatic system's role dissemination. Maintaining is crucial overall well‐being.

Language: Английский

Citations

0