Interplay of m6A RNA methylation and gut microbiota in modulating gut injury

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 17, 2025

The gut microbiota undergoes continuous variations among individuals and across their lifespan, shaped by diverse factors encompassing diet, age, lifestyle choices, medication intake, disease states. These microbial inhabitants play a pivotal role in orchestrating physiological metabolic pathways through the production of metabolites like bile acids, choline, short-chain fatty neurotransmitters, thereby establishing dynamic "gut-organ axis" with host. intricate interplay between host is indispensable for health, RNA N6-methyladenosine modification, epigenetic mark on RNA, emerges as key player this process. M6A most prevalent internal modification eukaryotic has garnered significant attention realm epigenetics. Recent findings underscore its potential to influence diversity intestinal barrier function modulating gene expression patterns. Conversely, microbiota, impact landscape cells, may indirectly regulate recruitment activity m6A-modifying enzymes. This review endeavors delve into biological functions m6A consequences injury pathogenesis, elucidating partial possible mechanisms which maintain health homeostasis. Furthermore, it also explores crosstalk them injury, offering novel perspective that deepens our understanding underlying diseases.

Language: Английский

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Ficus pumila fruit polysaccharide alleviates OVA-induced allergic asthma mice through the MAPK/NF-κB signaling pathway

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105827 - 105827

Published: Jan. 1, 2025

Language: Английский

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Airway Microbiota Profiles in Children With and Without Asthma: A Comparative Study

Journal of Asthma and Allergy, Journal Year: 2025, Volume and Issue: Volume 18, P. 349 - 361

Published: March 1, 2025

Asthma is a common chronic respiratory disease that affects children and adults can have serious impact on their quality of life. Factors contributing to the development asthma related exacerbations are multifactorial, with microbial communities colonizing airways possibly playing key role. The study included asthmatic (79) healthy (57) aged 5-16 years. Nasal throat swabs were collected, bacterial (16s rRNA) fungal (18s amplicon sequence analysis was performed. Diversity indices most abundant genera estimated accordingly. At level bacteriome in nasal samples, group had significantly lower diversity than control (p = 0.02). However, microbiota cohort more evenly distributed, staphylococci enriched group. Throat samples collected from revealed < 0.0001), significant difference species composition between two groups 0.005). Enriched different within subgroups (controlled vs uncontrolled asthma). microbiome showed no richness groups, however, beta (species composition) detected. Malassezia species, while cases Mucor species. On other hand, specimens found be Candida Saccharomyces. Our findings suggest less diverse certain enriching some groups. Addressing biomarkers influence progression could lead improved care for suffering severe episodes, by including targeted therapies prevention strategies.

Language: Английский

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PROBIÓTICOS NO TRATAMENTO DO MIELOMA MÚLTIPLO: UMA REVISÃO

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, Journal Year: 2024, Volume and Issue: 5(6), P. e565340 - e565340

Published: June 7, 2024

O mieloma múltiplo (MM) é a segunda neoplasia hematológica mais comum, caracterizada pela proliferação descontrolada de células plasmáticas, resultando em complicações como anemia, lesões ósseas e insuficiência renal. Estudos sugerem que microbiota intestinal pode influenciar progressão do MM resposta ao tratamento. Nesse contexto, os probióticos, conhecidos por seus benefícios à saúde intestinal, apresentam potencial terapêutico para o tratamento MM, melhorando imunológica. Dessa forma, objetivou-se realizar uma revisão sistemática através Methodi Ordinatio sobre uso probióticos no múltiplo. As buscas foram feitas mês abril 2024, nas bases dados: Embase, Scopus Web of Science. Não empregados intervalos temporais. A busca resultou um total 104 publicações dos quais 2 atenderam aos critérios seleção. datam 2018 2024. maior valor InOrd foi alcançado pelo periódico Cell Metabolism, enquanto revista Probiotics and Antimicrobial Proteins apresentou número citações. Ambas revistas apresentaram alto fator impacto. Evidências preliminares prebióticos podem desencadear efeitos imunomoduladores anti-inflamatórios, condição geral pacientes. indicam desequilíbrio da doença eficácia tratamento, sublinhando necessidade investigações neste campo.

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