Investigating the causal relationship between immune cells and colorectal cancer risk using bidirectional and multivariable Mendelian randomization analysis DOI
Jiajie Zhou, Yeliu Liu

Journal of Receptors and Signal Transduction, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 26, 2025

This study explores the relationship between immune recognition diversity and colorectal cancer (CRC) risk using a bidirectional Mendelian randomization approach. Genetic data from 731 cell types were analyzed, with sourced IEU FinnGen databases CRC genome-wide association studies on Finnish population. Forward reverse analyses conducted, sensitivity to assess pleiotropic effects. Analyses revealed significant increased Effector Memory CD4 CD8 T cells higher (odds ratio [OR] = 1.11, 95% confidence interval [CI] 1.04-1.18, p .0008). Conversely, elevated CD45 natural killer was associated lower (OR 0.93, CI 0.88-0.98, .0095), indicating protective effect. Sensitivity confirmed no These findings highlight specific cells' roles in pathogenesis, suggesting potential avenues for immune-targeted therapies prevention. Given rising global incidence of CRC, understanding is crucial advancing effective treatments.

Language: Английский

CAFs-released exosomal CREB1 promotes cell progression and immune evasion in thyroid cancer via the positive regulation of CCL20 DOI Creative Commons

Zheng Chen,

Hu Hei,

Yifei Zhai

et al.

Autoimmunity, Journal Year: 2025, Volume and Issue: 58(1)

Published: Jan. 25, 2025

Exosomes derived from cancer-associated fibroblasts (CAFs) can affect tumor microenvironment (TME) of thyroid cancer (TC). The cAMP response element binding protein 1 (CREB1) acts as a transcription factor to participate in development. Currently, we aimed explore the molecular mechanism exosome-associated CREB1 and C-C motif chemokine ligand 20 (CCL20) TC. mRNA levels were examined via RT-qPCR western blot. Gene interaction was analyzed using ChIP dual-luciferase reporter assays. Cell migration, invasion proliferation assessed by wound healing, transwell EdU characterized morphology observation apoptosis CD8+ T cells detected immunofluorescence flow cytometry. In vivo assays performed establishing xenograft models. highly expressed positively interacted with CCL20 facilitated TC cell targeting CCL20. expression reduced transferring CAFs-secreted exosomes sheltering downregulation. Exosomal knockdown receded progression enhanced function mediating CAFs-associated exosomal downregulation inhibited tumorigenesis through affecting CAFs-derived accelerated malignant behaviors immune evasion carrying up-regulate

Language: Английский

Citations

0
The Emerging Role of CD8+ T Cells in Shaping Treatment Outcomes of Patients with MDS and AML DOI Open Access
Athanasios Tasis,

Theodoros Spyropoulos,

Ioannis Mitroulis

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 749 - 749

Published: Feb. 22, 2025

CD8+ T cells are critical players in anti-tumor immunity against solid tumors, targeted by immunotherapies. Emerging evidence suggests that also play a crucial role responses and determining treatment outcomes hematologic malignancies like myelodysplastic neoplasms (MDS) acute myeloid leukemia (AML). In this review, we focus on the implication of response patients with MDS AML. First, review reported studies aberrant functionality clonality AML, often driven immunosuppressive bone marrow microenvironment, which can hinder effective antitumor immunity. Additionally, discuss potential use cell subpopulations, including memory senescent-like subsets, as predictive biomarkers for to variety regimens, such hypomethylating agents, is standard care higher-risk MDS, chemotherapy main Understanding multifaceted their interaction malignant AML will provide useful insights into prognostic/predictive biomarkers, but uncover alternative approaches novel strategies could reshape therapeutic landscape, thus improving efficacy, aiding overcoming resistance patient survival these challenging neoplasms.

Language: Английский

Citations

0
Defeating lethal cancer: Interrupting the ecologic and evolutionary basis of death from malignancy DOI Open Access
Kenneth J. Pienta,

Patrick L. Goodin,

Sarah R. Amend

et al.

CA A Cancer Journal for Clinicians, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Despite the advances in cancer prevention, early detection, and treatments, all of which have led to improved survival, globally, there is an increased incidence cancer-related deaths. Although each patient tumor wholly unique, tipping point incurable disease common across patients: dual capacity for cancers metastasize resist systemic treatment. The discovery genetic mutations epigenetic variation that emerges during progression highlights evolutionary ecology principles can be used understand how evolves a lethal phenotype. By applying such eco-evolutionary framework, authors reinterpret our understanding metastatic process as one ecologic invasion define paths evolving therapy resistance. With this understanding, draw from successful strategies optimized strategic interventions with goal altering trajectory cancer. Ultimately, studying, treating using provides opportunity improve lives patients

Language: Английский

Citations

0
Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

et al.

Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Language: Английский

Citations

0
Investigating the causal relationship between immune cells and colorectal cancer risk using bidirectional and multivariable Mendelian randomization analysis DOI
Jiajie Zhou, Yeliu Liu

Journal of Receptors and Signal Transduction, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 26, 2025

This study explores the relationship between immune recognition diversity and colorectal cancer (CRC) risk using a bidirectional Mendelian randomization approach. Genetic data from 731 cell types were analyzed, with sourced IEU FinnGen databases CRC genome-wide association studies on Finnish population. Forward reverse analyses conducted, sensitivity to assess pleiotropic effects. Analyses revealed significant increased Effector Memory CD4 CD8 T cells higher (odds ratio [OR] = 1.11, 95% confidence interval [CI] 1.04-1.18, p .0008). Conversely, elevated CD45 natural killer was associated lower (OR 0.93, CI 0.88-0.98, .0095), indicating protective effect. Sensitivity confirmed no These findings highlight specific cells' roles in pathogenesis, suggesting potential avenues for immune-targeted therapies prevention. Given rising global incidence of CRC, understanding is crucial advancing effective treatments.

Language: Английский

Citations

0