Hypoxic control of metastasis

Science, Journal Year: 2016, Volume and Issue: 352(6282), P. 175 - 180

Published: April 7, 2016

Metastatic disease is the leading cause of cancer-related deaths and involves critical interactions between tumor cells microenvironment. Hypoxia a potent microenvironmental factor promoting metastatic progression. Clinically, hypoxia expression hypoxia-inducible transcription factors HIF-1 HIF-2 are associated with increased distant metastasis poor survival in variety types. Moreover, HIF signaling malignant influences multiple steps within cascade. Here we review research focused on elucidating mechanisms by which hypoxic microenvironment promotes These studies have identified potential biomarkers therapeutic targets regulated that could be incorporated into strategies aimed at preventing treating disease.

Language: Английский

---

Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: June 23, 2021

The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of disease 2019 (COVID-19). Across the globe, subset patients who sustain an SARS-CoV-2 infection are developing wide range persistent symptoms that do not resolve over course many months. These being given diagnosis Long COVID or Post-acute sequelae COVID-19 (PASC). It is likely individual with PASC have different underlying biological factors driving their symptoms, none which mutually exclusive. This paper details mechanisms by RNA viruses beyond just be connected to long-term health consequences. also reviews literature on and other virus-initiated chronic syndromes such as post-Ebola myalgic encephalomyelitis/chronic fatigue (ME/CFS) discuss scenarios for symptom development. Potential contributors include consequences from injury one multiple organs, reservoirs in certain tissues, re-activation neurotrophic pathogens herpesviruses under conditions immune dysregulation, interactions host microbiome/virome communities, clotting/coagulation issues, dysfunctional brainstem/vagus nerve signaling, ongoing activity primed cells, autoimmunity due molecular mimicry between pathogen proteins. individualized nature suggests therapeutic approaches may required best manage care specific diagnosis.

Language: Английский

---

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

Seminars in Cancer Biology, Journal Year: 2015, Volume and Issue: 35, P. S25 - S54

Published: April 17, 2015

Proliferation is an important part of cancer development and progression. This manifest by altered expression and/or activity cell cycle related proteins. Constitutive activation many signal transduction pathways also stimulates growth. Early steps in tumor are associated with a fibrogenic response the hypoxic environment which favors survival proliferation stem cells. Part strategy cells may manifested alterations metabolism. Once tumors appear, growth metastasis be supported overproduction appropriate hormones (in hormonally dependent cancers), promoting angiogenesis, undergoing epithelial to mesenchymal transition, triggering autophagy, taking cues from surrounding stromal A number natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene quercetin) have been found inhibit one or more that contribute hypoxia inducible factor 1, nuclear kappa B, phosphoinositide 3 kinase/Akt, insulin-like receptor Wnt, proteins, as well androgen estrogen signaling). These data, combination bioinformatics analyses, will very for identifying signaling molecular targets provide early diagnostic markers critical new drugs drug combinations block formation

Language: Английский

---

Autophagy: The spotlight for cellular stress responses

Life Sciences, Journal Year: 2017, Volume and Issue: 188, P. 53 - 67

Published: Sept. 1, 2017

Language: Английский

---

Regulation of immunity and inflammation by hypoxia in immunological niches

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 17(12), P. 774 - 785

Published: Oct. 3, 2017

Language: Английский

---

The Role of HIF in Immunity and Inflammation

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(4), P. 524 - 536

Published: Aug. 26, 2020

Language: Английский

---

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Nature, Journal Year: 2019, Volume and Issue: 573(7772), P. 69 - 74

Published: Aug. 21, 2019

Language: Английский

---

Understanding Subset Diversity in T Cell Memory

Immunity, Journal Year: 2018, Volume and Issue: 48(2), P. 214 - 226

Published: Feb. 1, 2018

Language: Английский

---

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Cancer Cell, Journal Year: 2017, Volume and Issue: 32(5), P. 669 - 683.e5

Published: Nov. 1, 2017

Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation the hypoxic tumor microenvironment. Deletion analyses of two key isoforms found that HIF-1α, but not HIF-2α, was essential for effector state in CD8+ cells. Furthermore, loss HIF-1α reduced infiltration and cell killing, altered vascularization. VEGF-A, an target gene, accelerated tumorigenesis while also altering Analyses human breast cancer showed inverse correlations between VEGF-A expression infiltration, a link These data demonstrate HIF-1α/VEGF-A axis is aspect immunity.

Language: Английский

---

Klebsiella pneumoniaeinfection biology: living to counteract host defences

FEMS Microbiology Reviews, Journal Year: 2018, Volume and Issue: 43(2), P. 123 - 144

Published: Nov. 17, 2018

Klebsiella species cause a wide range of diseases including pneumonia, urinary tract infections (UTIs), bloodstream and sepsis. These are particularly problem among neonates, elderly immunocompromised individuals. is also responsible for significant number community-acquired infections. A defining feature these their morbidity mortality, the strains associated with them considered hypervirulent. The increasing isolation multidrug-resistant has significantly narrowed, or in some settings completely removed, therapeutic options treatment Not surprisingly, this pathogen then been singled out as an 'urgent threat to human health' by several organisations. This review summarises tremendous progress that made uncover sophisticated immune evasion strategies K. pneumoniae. co-evolution response challenge activated formidable exploiting stealth actively suppressing innate defences overcome host responses survive tissues. better understanding context host-pathogen interactions pivotal develop new therapeutics, which can be based on antagonising anti-immune pathogen.

Language: Английский

---