Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year DOI Creative Commons
Elizabeth A. Kennedy,

Jennifer Connolly,

Jonathan O’B Hourihane

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2016, Volume and Issue: 139(1), P. 166 - 172

Published: Sept. 9, 2016

Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition the microbiome between early infancy dysbiosis AD is unknown.We randomly selected 50 children from Cork Babies After SCOPE: Evaluating Longitudinal Impact Using Neurological Nutritional Endpoints (BASELINE) longitudinal birth cohort for sampling at 3 points in first 6 months life 4 sites relevant to AD: antecubital popliteal fossae, nasal tip, cheek. We identified 10 infants compared them control no AD. performed bacterial 16S ribosomal RNA sequencing analysis directly clinical samples.Bacterial community structures diversity shifted over time, suggesting that age strongly affects infants. Unlike AD, these patients infantile did not have noticeably dysbiotic communities before or disease were colonized by S aureus. In comparing subjects, who had affected month 12 statistically significant differences on fossa 2 unaffected 12. particular, commensal staphylococci significantly less abundant 12, this genus might protect against later development AD.This study suggests 12-month-old having Additional studies needed confirm whether colonization modulates immunity attenuates

Language: Английский

Host–microbiota interactions in immune-mediated diseases DOI
William Ruff, Teri M. Greiling, Martin Kriegel

et al.

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 18(9), P. 521 - 538

Published: May 26, 2020

Language: Английский

Citations

372
Microbiota and maintenance of skin barrier function DOI Open Access
Tamia Harris-Tryon, Elizabeth A. Grice

Science, Journal Year: 2022, Volume and Issue: 376(6596), P. 940 - 945

Published: May 26, 2022

Human skin forms a protective barrier against the external environment and is our first line of defense toxic, solar, pathogenic insults. Our also defines outward appearance, protects internal tissues organs, acts as sensory interface, prevents dehydration. Crucial to skin's function colonizing microbiota, which provides protection pathogens, tunes immune responses, fortifies epithelium. Here we highlight recent advances in understanding how microbiota mediates multiple facets function. We discuss insights into pathological host-microbiota interactions implications for disorders distant organs. Finally, examine microbiota-based mechanisms can be targeted prevent or manage impaired wound healing.

Language: Английский

Citations

351
Priority effects in microbiome assembly DOI
Reena Debray, Robin A. Herbert, Alexander L. Jaffe

et al.

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 20(2), P. 109 - 121

Published: Aug. 27, 2021

Language: Английский

Citations

323
Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression DOI Creative Commons
Teruaki Nakatsuji, Tiffany H. Chen,

Aimee Two

et al.

Journal of Investigative Dermatology, Journal Year: 2016, Volume and Issue: 136(11), P. 2192 - 2200

Published: July 3, 2016

Language: Английский

Citations

312
Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year DOI Creative Commons
Elizabeth A. Kennedy,

Jennifer Connolly,

Jonathan O’B Hourihane

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2016, Volume and Issue: 139(1), P. 166 - 172

Published: Sept. 9, 2016

Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition the microbiome between early infancy dysbiosis AD is unknown.We randomly selected 50 children from Cork Babies After SCOPE: Evaluating Longitudinal Impact Using Neurological Nutritional Endpoints (BASELINE) longitudinal birth cohort for sampling at 3 points in first 6 months life 4 sites relevant to AD: antecubital popliteal fossae, nasal tip, cheek. We identified 10 infants compared them control no AD. performed bacterial 16S ribosomal RNA sequencing analysis directly clinical samples.Bacterial community structures diversity shifted over time, suggesting that age strongly affects infants. Unlike AD, these patients infantile did not have noticeably dysbiotic communities before or disease were colonized by S aureus. In comparing subjects, who had affected month 12 statistically significant differences on fossa 2 unaffected 12. particular, commensal staphylococci significantly less abundant 12, this genus might protect against later development AD.This study suggests 12-month-old having Additional studies needed confirm whether colonization modulates immunity attenuates

Language: Английский

Citations

311