Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node DOI Creative Commons
Eric B. Wong,

Ren-Huan Xu,

Daniel Rubio

et al.

Cell Reports, Journal Year: 2018, Volume and Issue: 24(1), P. 142 - 154

Published: July 1, 2018

Circulating natural killer (NK) cells help protect the host from lympho-hematogenous acute viral diseases by rapidly entering draining lymph nodes (dLNs) to curb virus dissemination. Here, we identify a highly choreographed mechanism underlying this process. Using footpad infection with ectromelia virus, pathogenic DNA of mice, show that TLR9/MyD88 sensing induces NKG2D ligands in virus-infected, skin-derived migratory dendritic (mDCs) induce production IFN-γ classical NK and other types group 1 innate lymphoid (ILCs) already dLNs, via NKG2D. Uninfected inflammatory monocytes, also recruited dLNs mDCs TLR9/MyD88-dependent manner, respond secreting CXCL9 for optimal CXCR3-dependent recruitment circulating cells. This work unveils whereby three cell types—mDCs, ILCs (mostly cells), monocytes—coordinate protective dLNs.

Language: Английский

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis DOI Creative Commons
Qianquan Ma, Changsheng Xing, Wenyong Long

et al.

Journal of Neuroinflammation, Journal Year: 2019, Volume and Issue: 16(1)

Published: March 1, 2019

Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under physiological pathological conditions. Although there anatomical separation, emerging evidence has indicated the existence bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), brain. The cross-talk microbiota brain may crucial impact during basic neurogenerative processes, in neurodegenerative disorders tumors CNS. In this review, we discuss biological interplay gut-brain axis, further explore how communication be dysregulated diseases. Further, highlight new insights modification composition, which emerge as a promising therapeutic approach to treat CNS disorders.

Language: Английский

Citations

612
CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming DOI Creative Commons

Anna Brewitz,

Sarah Eickhoff,

Sabrina Dähling

et al.

Immunity, Journal Year: 2017, Volume and Issue: 46(2), P. 205 - 219

Published: Feb. 1, 2017

Language: Английский

Citations

295
Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response DOI Creative Commons

Dongshan Wan,

Wei Jiang, Junwei Hao

et al.

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: April 28, 2020

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics research. The intrinsic function cGAS-STING facilitates type-I (IFN) and other inflammatory signaling responses. pathway modulates cellular processes such autophagy, cell survival, senescence interplays innate immune pathways, by which it participates in regulating infection, disease cancer. therapeutic approaches targeting this show promise for future translation into clinical applications. Here, we present a review important previous works recent advances regarding pathway, provide comprehensive understanding modulatory pattern under diverse pathologic states.

Language: Английский

Citations

214
Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles DOI
Claire Vanpouille‐Box,

Jules A. Hoffmann,

Lorenzo Galluzzi

et al.

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 18(11), P. 845 - 867

Published: Sept. 25, 2019

Language: Английский

Citations

150
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity DOI Creative Commons
Francesco Borriello, Valentina Poli, Ellen Shrock

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(4), P. 614 - 629.e21

Published: Feb. 1, 2022

Language: Английский

Citations

82
Sources of Type I Interferons in Infectious Immunity: Plasmacytoid Dendritic Cells Not Always in the Driver's Seat DOI Creative Commons
Shafaqat Ali, Ritu Mann‐Nüttel, Anja Schulze

et al.

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: April 12, 2019

Type I Interferons (IFNs) are hallmark cytokines produced in immune responses to all classes of pathogens. IFNs can influence dendritic cell (DC) activation, maturation, migration, and survival, but also directly enhance natural killer (NK) T/B activity, thus orchestrating various innate adaptive effector functions. Therefore, type have long been considered essential the host defense against virus infections. More recently, it has become clear that depending on course infection, production IFN lead immunopathology or immunosuppression. Similarly, bacterial infections is often associated with detrimental effects for host. Although most cells body thought be able produce IFN, plasmacytoid DCs (pDCs) termed "IFN producing cells" due their unique molecular adaptations nucleic acid sensing ability high amounts IFN. Findings from mouse reporter strains depletion experiments

Language: Английский

Citations

141
Innate Sensing of DNA Virus Genomes DOI
Zhe Ma, Guoxin Ni, Blossom Damania

et al.

Annual Review of Virology, Journal Year: 2018, Volume and Issue: 5(1), P. 341 - 362

Published: Sept. 28, 2018

DNA viruses are linked to many infectious diseases and contribute significantly human morbidity mortality worldwide. Moreover, viral infections usually lifelong hard eradicate. Under certain circumstances, these can cause fatal disease, especially in children immunocompromised patients. An efficient innate immune response against is critical, not only as the first line of host defense infection but also for mounting more specific robust adaptive immunity virus. Recognition genome very step this whole process crucial understanding pathogenesis well preventing treating virus-associated diseases. This review focuses on current state our knowledge how sensed by system proteins counteract response.

Language: Английский

Citations

128
Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion DOI Creative Commons
Huibin Yu, Ryan C. Bruneau, Greg Brennan

et al.

Biomedicines, Journal Year: 2021, Volume and Issue: 9(7), P. 765 - 765

Published: July 1, 2021

Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns (PAMPs), which are signatures shared by different pathogens. Recognition of PAMPs PRRs initiate innate immune responses via diverse signaling pathways. Over recent decades, advances in our knowledge sensing have enhanced understanding the host response to poxviruses. Multiple PRR families been implicated poxvirus detection, mediating initiation cascades, activation transcription factors, and, ultimately, expression antiviral effectors. To counteract defense, poxviruses evolved a variety immunomodulators that strategies disrupt or circumvent triggered PRRs. These interactions influence outcomes infections. This review focuses on current roles poxviruses, their elicited effector functions, and how poxviral antagonize PRR-mediated responses.

Language: Английский

Citations

80
Nucleic Acid Sensors as Therapeutic Targets for Human Disease DOI Creative Commons
Sarah M. McWhirter, Caroline A. Jefferies

Immunity, Journal Year: 2020, Volume and Issue: 53(1), P. 78 - 97

Published: July 1, 2020

Language: Английский

Citations

77
Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity DOI Creative Commons
Ayesha Zahid,

Hazrat Ismail,

Bofeng Li

et al.

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Nov. 30, 2020

DNA viruses are a source of great morbidity and mortality throughout the world by causing many diseases; thus, we need substantial knowledge regarding viral pathogenesis host’s antiviral immune responses to devise better preventive therapeutic strategies. The innate system utilizes numerous germ-line encoded receptors called pattern-recognition (PRRs) detect various pathogen-associated molecular patterns (PAMPs) such as nucleic acids, ultimately resulting in form proinflammatory cytokines type I interferons. immune-stimulatory role is known for long time; however, sensing ability was unraveled only recently. At present, multiple sensors have been proposed, most them use STING key adaptor protein exert responses. In this review, aim provide structural underpinnings on endosomal sensor Toll-like receptor 9 (TLR9) cytosolic including cyclic GMP-AMP synthase (cGAS), interferon-gamma inducible 16 (IFI16), absent melanoma 2 (AIM2), DNA-dependent activator IRFs (DAI) new insights their signaling mechanisms physiological relevance. We also addressed less well-understood DEAD-box helicase DDX41, RNA polymerase III (RNA pol III), kinase (DNA-PK), meiotic recombination 11 homolog A (MRE11). By comprehensive understanding aspects DNA-sensing pathways, potential targets autoimmune diseases can be identified.

Language: Английский

Citations

77