Frontiers in Oncology,
Journal Year:
2019,
Volume and Issue:
9
Published: Feb. 11, 2019
Despite
advances
in
the
diagnostic
and
therapeutic
modalities,
prognosis
of
several
solid
tumor
malignancies
remains
poor.
Different
factors
associated
with
tumors
including
a
varied
genetic
signature,
complex
molecular
signaling
pathways,
defective
cross
talk
between
cells
immune
cells,
hypoxic
immunosuppressive
effects
microenvironment
result
treatment
resistant
metastatic
phenotype.
Over
past
years,
immunotherapy
has
emerged
as
an
attractive
option
against
multiple
malignancies.
The
unique
ability
natural
killer
(NK)
to
target
cancer
without
antigen
specificity
makes
them
ideal
candidate
for
use
tumors.
However,
outcomes
adoptive
NK
cell
infusions
into
patients
have
been
disappointing.
Extensive
studies
done
investigate
different
strategies
improve
function,
trafficking
targeting.
Use
cytokines
cytokine
analogues
well
described
utilized
enhance
proliferation,
stimulation
persistence
cells.
Other
techniques
like
blocking
human
leukocyte
antigen-killer
receptors
(KIR)
interactions
anti-KIR
monoclonal
antibodies,
preventing
CD16
receptor
shedding,
increasing
expression
activating
NKG2D,
immunocytokines
checkpoint
inhibitors
can
mediated
cytotoxicity.
Using
genetically
modified
chimeric
bispecific
trispecific
engagers,
be
effectively
redirected
improving
their
cytotoxic
potential.
In
this
review,
we
these
highlighted
need
further
optimize
clinical
outcome
based
Journal of Hematology & Oncology,
Journal Year:
2021,
Volume and Issue:
14(1)
Published: Jan. 6, 2021
Abstract
Natural
killer
(NK)
cell
is
a
specialized
immune
effector
type
that
plays
critical
role
in
activation
against
abnormal
cells.
Different
from
events
required
for
T
activation,
NK
governed
by
the
interaction
of
receptors
with
target
cells,
independent
antigen
processing
and
presentation.
Due
to
relatively
unsophisticated
cues
has
gained
significant
attention
field
cancer
immunotherapy.
Many
efforts
are
emerging
developing
engineering
cell-based
In
this
review,
we
provide
our
current
understandings
biology,
ongoing
pre-clinical
clinical
development
therapies
discuss
progress,
challenges,
future
perspectives.
Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: Oct. 7, 2020
The
risk
and
severity
of
some
specific
infections
are
increased
during
pregnancy
due
to
a
combination
physiological
immunological
changes.
Characterizing
the
normal
adaptations
is
important
understand
how
maternal
immune
system
maintains
tolerance
towards
allogeneic
fetus.
This
may
also
inform
strategies
prevent
fatalities
optimize
vaccination
best
protect
mother-fetus
dyad
infant
after
birth.
In
this
review,
we
describe
what
known
about
changes
that
occur
pregnancy.
Immunity,
Journal Year:
2018,
Volume and Issue:
49(5), P. 971 - 986.e5
Published: Nov. 1, 2018
Natural
killer
(NK)
cells
are
innate
lymphoid
(ILCs)
involved
in
antimicrobial
and
antitumoral
responses.
Several
NK
cell
subsets
have
been
reported
humans
mice,
but
their
heterogeneity
across
organs
species
remains
poorly
characterized.
We
assessed
the
diversity
of
human
mouse
by
single-cell
RNA
sequencing
on
thousands
individual
isolated
from
spleen
blood.
Unbiased
transcriptional
clustering
revealed
two
distinct
signatures
differentiating
between
splenic
blood
cells.
This
analysis
at
resolution
identified
three
subpopulations
four
spleen,
each
A
comparison
transcriptomic
profiles
within
highlighted
similarity
major
subsets,
NK1
NK2,
species.
unbiased
approach
provides
insight
into
biology
establishes
a
rationale
for
translation
studies
to
physiology
disease.
Cancer Discovery,
Journal Year:
2020,
Volume and Issue:
11(1), P. 34 - 44
Published: Dec. 4, 2020
Abstract
Because
of
their
potent
antitumor
activity
and
proinflammatory
role,
natural
killer
(NK)
cells
are
at
the
forefront
efforts
to
develop
immuno-oncologic
treatments.
NK
participate
in
immune
responses
tumors
by
killing
target
producing
cytokines.
However,
immunosuppressive
tumor
microenvironment,
become
dysfunctional
through
exposure
inhibitory
molecules
produced
cancer
cells,
leading
escape.
We
provide
an
overview
what
is
known
about
infiltration
surveillance
mechanisms
which
dysfunctional.
Significance:
The
functions
tumor-infiltrating
may
be
impaired.
This
review
aims
describe
various
alter
NK-cell
functions.
Frontiers in Immunology,
Journal Year:
2019,
Volume and Issue:
10
Published: May 28, 2019
Natural
killer
(NK)
cells
contribute
to
the
first
line
of
defense
against
viruses
and
control
tumor
growth
metastasis
spread.
The
discovery
HLA
class
I
specific
inhibitory
receptors,
primarily
Ig-like
receptors
(KIRs),
activating
has
been
fundamental
unravel
NK
cell
function
molecular
mechanisms
killing.
Stemmed
from
seminal
discoveries
in
early
'90s,
which
Alessandro
Moretta
was
major
actor,
an
extraordinary
amount
research
on
KIR
specificity,
genetics,
polymorphism,
repertoire
followed.
These
basic
notions
their
have
successfully
translated
clinical
applications,
haploidentical
hematopoietic
stem
transplantation
cure
otherwise
fatal
leukemia
patients
with
no
compatible
donors.
finding
that
may
express
PD-1
checkpoint,
particularly
cancer
patients,
allow
understanding
how
anti-PD-1
therapy
could
also
case
