Cell, Journal Year: 2020, Volume and Issue: 181(5), P. 1004 - 1015.e15
Published: May 1, 2020
Language: Английский
The Lancet, Journal Year: 2021, Volume and Issue: 397(10270), P. 220 - 232
Published: Jan. 1, 2021
Language: Английский
Citations
3992
Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(3), P. 155 - 170
Published: Oct. 28, 2020
The SARS-CoV-2 pandemic and its unprecedented global societal economic disruptive impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into human population. Although previous SARS-CoV MERS-CoV epidemics raised awareness need for clinically available therapeutic or preventive interventions, to date, no treatments with proven efficacy are available. development effective intervention strategies relies on knowledge molecular cellular mechanisms infections, which highlights significance studying virus-host interactions at level identify targets antiviral elucidate critical viral host determinants that decisive severe disease. In this Review, we summarize first discoveries shape our current understanding infection throughout intracellular life cycle relate biology. elucidation similarities differences between other coronaviruses will support future preparedness combat infections.
Language: Английский
Citations
2847
Nature, Journal Year: 2020, Volume and Issue: 586(7830), P. 594 - 599
Published: Sept. 30, 2020
Language: Английский
Citations
1837
Cell, Journal Year: 2020, Volume and Issue: 183(4), P. 996 - 1012.e19
Published: Sept. 16, 2020
Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches adaptive immunity at level SARS-CoV-2-specific CD4
Language: Английский
Citations
1808
Science, Journal Year: 2020, Volume and Issue: 369(6508)
Published: July 15, 2020
Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry analyze 125 COVID-19 patients and compare them with recovered healthy individuals. Integrated analysis of ~200 ~50 clinical features revealed activation T cell B subsets in proportion patients. A subgroup had characteristic acute viral infection plasmablast reaching >30% circulating cells. However, another lymphocyte comparable that uninfected Stable versus dynamic immunological signatures were identified linked trajectories severity change. Our analyses three immunotypes associated poor improving health. These may have implications for design therapeutics vaccines COVID-19.
Language: Английский
Citations
1544
Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)
Published: March 27, 2020
Dear Editor
Language: Английский
Citations
1528
Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)
Published: May 4, 2020
Abstract The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment this are currently lacking. Here we report monoclonal antibody that neutralizes (and SARS-CoV) cell culture. This cross-neutralizing targets communal epitope on these viruses may offer potential prevention COVID-19.
Language: Английский
Citations
1129
Gut, Journal Year: 2021, Volume and Issue: 70(4), P. 698 - 706
Published: Jan. 11, 2021
Although COVID-19 is primarily a respiratory illness, there mounting evidence suggesting that the GI tract involved in this disease. We investigated whether gut microbiome linked to disease severity patients with COVID-19, and perturbations composition, if any, resolve clearance of SARS-CoV-2 virus.In two-hospital cohort study, we obtained blood, stool patient records from 100 laboratory-confirmed infection. Serial samples were collected 27 up 30 days after SARS-CoV-2. Gut compositions characterised by shotgun sequencing total DNA extracted stools. Concentrations inflammatory cytokines blood markers measured plasma.Gut composition was significantly altered compared non-COVID-19 individuals irrespective had received medication (p<0.01). Several commensals known immunomodulatory potential such as Faecalibacterium prausnitzii, Eubacterium rectale bifidobacteria underrepresented remained low resolution. Moreover, perturbed exhibited stratification concordant elevated concentrations C reactive protein, lactate dehydrogenase, aspartate aminotransferase gamma-glutamyl transferase.Associations between microbiota levels suggest magnitude possibly via modulating host immune responses. Furthermore, dysbiosis resolution could contribute persistent symptoms, highlighting need understand how microorganisms are inflammation COVID-19.
Language: Английский
Citations
1119
Cytokine & Growth Factor Reviews, Journal Year: 2020, Volume and Issue: 54, P. 62 - 75
Published: June 2, 2020
Language: Английский
Citations
1084
Obesity Reviews, Journal Year: 2020, Volume and Issue: 21(11)
Published: Aug. 26, 2020
The linkage of individuals with obesity and COVID-19 is controversial lacks systematic reviews. After a search the Chinese English language literature on COVID-19, 75 studies were used to conduct series meta-analyses relationship obesity-COVID-19 over full spectrum from risk mortality. A review mechanistic pathways for presented. Pooled analysis show more at positive, >46.0% higher (OR = 1.46; 95% CI, 1.30-1.65; p < 0.0001); hospitalization, 113% 2.13; 1.74-2.60; ICU admission, 74% 1.74; 1.46-2.08); mortality, 48% increase in deaths 1.48; 1.22-1.80; 0.001). Mechanistic are presented depth factors linked risk, severity their potential diminished therapeutic prophylactic treatments among these individuals. Individuals large significant increases morbidity mortality COVID-19. There many mechanisms that jointly explain this impact. major concern vaccines will be less effective obesity.
Language: Английский
Citations
1070