Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
156, P. 113686 - 113686
Published: Oct. 13, 2022
Metformin
as
a
first-line
drug
for
type
2
diabetes
mellitus(T2DM)
treatment
is
widely
studied.
can
reduce
liver
glucose
output
and
improve
insulin
resistance.
Recent
evidence
from
in
vivo
vitro
has
confirmed
that
metformin
transport
across
the
blood-brain
barrier(BBB)
activate
specific
neurons
neuroglia
to
exert
neurological
actions,
however,
effect
of
regulation
on
CNS
still
obscure.
In
this
review,
we
summarized
current
preclinical
focusing
regulatory
role
found
potential
neuroprotective,
neurotrophic,
neurogenesis-stimulated
actions;
besides,
also
exerts
antiinflammatory
by
inhibiting
microglial
activates
regulating
polarization.
These
findings
indicate
there
might
be
extensive
pharmacological
efficacy
therapeutic
insights
diseases'
clinical
application.
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(12), P. 3113 - 3113
Published: Dec. 2, 2022
Many
people
infected
with
the
SARS-CoV-2
suffer
long-term
symptoms,
such
as
"brain
fog",
fatigue
and
clotting
problems.
Explanations
for
"long
COVID"
include
immune
imbalance,
incomplete
viral
clearance
potentially,
mitochondrial
dysfunction.
As
conditions
sub-optimal
function
are
associated
initial
severity
of
disease,
their
prior
health
could
be
key
in
resistance
to
long
COVID
recovery.
The
SARs
virus
redirects
host
metabolism
towards
replication;
response,
can
metabolically
react
control
virus.
Resolution
is
normally
achieved
after
stress
activates
a
hormetic
negative
feedback
mechanism.
It
therefore
possible
that,
some
individuals
function,
"tip"
into
chronic
inflammatory
cycle.
This
might
explain
main
including
platelet
Long
thus
described
virally
induced
self-perpetuating
imbalanced
non-resolving
state
characterised
by
dysfunction,
where
reactive
oxygen
species
continually
drive
inflammation
shift
glycolysis.
would
suggest
that
sufferer's
needs
"tipped"
back
using
stimulus,
physical
activity,
calorie
restriction,
or
chemical
compounds
mimic
these
enhancing
perhaps
combination
inhibitors
quell
response.
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
156, P. 113686 - 113686
Published: Oct. 13, 2022
Metformin
as
a
first-line
drug
for
type
2
diabetes
mellitus(T2DM)
treatment
is
widely
studied.
can
reduce
liver
glucose
output
and
improve
insulin
resistance.
Recent
evidence
from
in
vivo
vitro
has
confirmed
that
metformin
transport
across
the
blood-brain
barrier(BBB)
activate
specific
neurons
neuroglia
to
exert
neurological
actions,
however,
effect
of
regulation
on
CNS
still
obscure.
In
this
review,
we
summarized
current
preclinical
focusing
regulatory
role
found
potential
neuroprotective,
neurotrophic,
neurogenesis-stimulated
actions;
besides,
also
exerts
antiinflammatory
by
inhibiting
microglial
activates
regulating
polarization.
These
findings
indicate
there
might
be
extensive
pharmacological
efficacy
therapeutic
insights
diseases'
clinical
application.
