Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 490 - 504
Published: March 1, 2023
Language: Английский
Cancer Communications, Journal Year: 2022, Volume and Issue: 42(11), P. 1112 - 1140
Published: Sept. 7, 2022
Abstract Multidimensional analyses have demonstrated the presence of a unique tumor microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are among most abundant immune cells infiltrating TME and present at all stages cancer progression, targeting TAMs has become one favored immunotherapy strategies. In addition, distinct origins. At early stage cancer, can provide niche for maintenance stem cells. contrast, (CSCs) or poorly differentiated key factors modulating macrophage activation. review, we first propose origin connection between precursor Macrophages undergo dynamic phenotypic transition during carcinogenesis. this course such transition, it is critical to determine appropriate timing therapy block specific markers suppress pro‐tumoral TAMs. The review provides more detailed discussion trends surface than previous reviews. Complex crosstalk occurs play indispensable roles angiogenesis, autophagy due their heterogeneity robust plasticity. interact with other by directing cell‐to‐cell contact secreting various effector molecules. Similarly, combined drive recruitment polarization. Despite latest achievements advancements treatment strategies following studies, comprehensive discussions on communication currently lacking. discussed interactions (from cell maturation), therapeutic (including chimeric antigen receptor macrophages), clinical trials hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (iCCA) rationale further investigation as potential target treating patients
Language: Английский
Citations
215
Nature Immunology, Journal Year: 2022, Volume and Issue: 23(2), P. 318 - 329
Published: Jan. 20, 2022
Abstract Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas infected tissues, the architecture and composition which are thought to affect disease outcome. However, our understanding spatial relationships that control human limited. Here, we used multiplexed ion beam imaging time flight (MIBI-TOF) image 37 proteins tissues from patients with active TB. We constructed a comprehensive atlas maps 19 cell subsets across 8 microenvironments. This shows an IFN-γ-depleted microenvironment enriched for TGF-β, regulatory T cells IDO1 + PD-L1 myeloid cells. In further transcriptomic meta-analysis peripheral blood TB, immunoregulatory trends mirror those identified granuloma imaging. Notably, expression associated progression TB treatment response. These data indicate granulomas, there local spatially coordinated programs systemic manifestations define
Language: Английский
Citations
187
Science Immunology, Journal Year: 2022, Volume and Issue: 7(70)
Published: April 1, 2022
Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating innate and adaptive immunity during infections, autoimmune diseases, malignancies. Since the discovery of DCs almost 50 years ago, our understanding their biology in humans has increased substantially. Here, we review both antitumor tolerogenic DC responses cancer discuss lineage-specific contributions by functionally specialized subsets, including conventional (cDC) subsets cDC1 cDC2, newly described DC3, plasmacytoid (pDCs), focusing on human setting. In addition, lineage-unrestricted "mature enriched immunoregulatory molecules" (mregDC) state recently across different tumors.
Language: Английский
Citations
165
Immunity, Journal Year: 2021, Volume and Issue: 54(9), P. 2101 - 2116.e6
Published: Aug. 31, 2021
Language: Английский
Citations
158
Cell, Journal Year: 2022, Volume and Issue: 185(23), P. 4317 - 4332.e15
Published: Oct. 26, 2022
Language: Английский
Citations
152
npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)
Published: Feb. 10, 2024
Abstract Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and immunosuppressive nature microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components TME. M2-like TAMs are in facilitating metastasis as well augmenting tumors. This review encapsulates mechanisms that use to promote resistance. We also describe emerging therapeutic strategies currently targeting combination with other antitumor drugs, some still undergoing clinical trial evaluation. Furthermore, we summarize analyze various existing approaches for developing novel drugs target overcome resistance, highlighting how can effectively stop growth, metastasis,
Language: Английский
Citations
148
Mucosal Immunology, Journal Year: 2022, Volume and Issue: 15(2), P. 223 - 234
Published: Jan. 11, 2022
The last decade has been somewhat of a renaissance period for the field macrophage biology. This renewed interest, combined with advent new technologies and development novel model systems to assess different facets biology, led major advances in our understanding diverse roles macrophages play health, inflammation, infection repair, dominance tissue environments influencing all these areas. Here, we discuss recent developments lung heterogeneity, ontogeny, metabolism function context health disease, highlight core conceptual key unanswered questions that believe should be focus work coming years.
Language: Английский
Citations
147
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(8), P. 538 - 553
Published: April 17, 2023
Language: Английский
Citations
132
Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(9), P. 983 - 992
Published: July 10, 2023
Abstract Macrophages are critical regulators of tissue homeostasis but also abundant in the tumor microenvironment (TME). In both primary tumors and metastases, such tumor-associated macrophages (TAMs) seem to support development. While we know that TAMs dominant immune cells TME, their vast heterogeneity associated functions only just being unraveled. this review, outline various known TAM populations found thus far delineate specialized roles with main stages cancer progression. We discuss how may prime premetastatic niche enable growth a metastasis then subsequent metastasis-associated can secondary growth. Finally, speculate on challenges remain be overcome research.
Language: Английский
Citations
132
Nature, Journal Year: 2023, Volume and Issue: 623(7986), P. 415 - 422
Published: Nov. 1, 2023
Language: Английский
Citations
132