Control of adaptive immunity by pattern recognition receptors

Immunity, Journal Year: 2024, Volume and Issue: 57(4), P. 632 - 648

Published: April 1, 2024

Language: Английский

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Focus on fungi

Cell, Journal Year: 2024, Volume and Issue: 187(19), P. 5121 - 5127

Published: Sept. 1, 2024

Language: Английский

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Dendritic cell maturation in cancer

Nature reviews. Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

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Current status of mannose receptor-targeted drug delivery for improved anti-HIV therapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 494 - 521

Published: June 27, 2024

Language: Английский

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DAMPs in immunosenescence and cancer

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 123 - 142

Published: Sept. 30, 2024

Language: Английский

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Plasmacytoid dendritic cells at the forefront of anti-cancer immunity: rewiring strategies for tumor microenvironment remodeling

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: July 17, 2024

Abstract Plasmacytoid dendritic cells (pDCs) are multifaceted immune executing various innate immunological functions. Their first line of defence consists in type I interferons (I-IFN) production upon nucleic acids sensing through endosomal Toll-like receptor (TLR) 7- and 9-dependent signalling pathways. Type IFNs a class proinflammatory cytokines that have context-dependent functions on cancer immunosurveillance immunoediting. In the last few years, different studies reported pDCs also able to sense cytosolic DNA cGAS–STING (stimulator interferon genes) pathway eliciting potent I-IFN independently TLR7/9. Human endowed with direct effector via upregulation TRAIL granzyme B, latter modulated by abundant tissues. been detected wide variety human malignant neoplasms, including virus-associated cancers, recruited chemotactic stimuli. Although role surveillance is still uncompletely understood, their spontaneous activation has rarely documented; moreover, presence tumor microenvironment (TME) associated tolerogenic phenotype induced immunosuppressive or oncometabolites. Currently tested treatment options can lead disruption TME, providing relevant clinical benefit. On contrary, antibody–drug conjugates targeting BDCA-2 tumor-associated (TA-pDCs) could be proposed as novel immunomodulatory therapies achieve disease control patients advance stage hematologic malignancies solid tumors. This Review integrate recent evidence biology pharmacological modulation, suggesting at forefront immunity.

Language: Английский

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The danger theory of immunity revisited

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(12), P. 912 - 928

Published: Nov. 7, 2024

Language: Английский

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DAMPs, PAMPs, NLRs, RIGs, CLRs and TLRs – Understanding the Alphabet Soup in the Context of Bone Biology

Current Osteoporosis Reports, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 14, 2025

Language: Английский

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Non-Immune Functions of Innate Immunity Acting on Physiological Processes: Insights from Drosophila

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1087 - 1087

Published: Jan. 27, 2025

As the first line of host immune defense, innate immunity plays a key role in warding off foreign pathogens and damage. Drosophila melanogaster, as classical model animal for more than 100 years, is an important research studying immunity. In recent scientists have made remarkable progress recognition mechanisms immunity, effector molecules, modes their response at cellular tissue levels. However, interaction between other physiological functions remains relatively novel has yet to be systematically explored. Here, we briefly discuss link system regulation, from several representative perspectives such sleep, insulin, brain function. Then, using model, provide overview specifically summarize on regulation physiology by covering lipid metabolism, development, neurodegenerative diseases, memory, feeding, lifespan, movement, antioxidation. This review provides valuable into how influences processes, providing deeper understanding complex roles underlying

Language: Английский

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Glyco-PAINT-APP: Subcellular analysis of immune cell-lectin binding enables correlation of glycan binding parameters to receptor biology

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Extracting single-molecule glycan binding data from primary cells has not been possible to date. Here, we present Glyco-PAINT-APP (Automated Processing Pipeline), an automated method that enables the extraction of subcellular interaction kinetics using a Points Accumulation for Imaging in Nano-Topography (PAINT)-based approach. This approach leverages algorithm precise, high-throughput analysis dynamics, facilitating exploration functional correlations between glycoform patterns and immune cell polarization. Using synthetic glycans glycosylated antigens, demonstrate ability technique automatically correlate high regions dendritic with increased uptake cross-presentation efficiency these antigens. Additionally, show how can uncover subtle differences preferences resting polarized macrophages. Taken together, potential enable new insights into cell-intrinsic heterogeneity glycan-structure-activity relationships cells.

Language: Английский

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