Early Progenitors of Innate Lymphoid Cells (ILC) DOI
Arundhoti Das, Yi Ding, Avinash Bhandoola

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Helper ILCs in the human hematopoietic system DOI
Xiaoyu Su, Zhaoqun Deng, Yu Lan

et al.

Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease DOI Open Access
Jongho Ham,

Weikang Yang,

Hye Young Kim

et al.

Immune Network, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 1, 2025

Recent advances have highlighted the crucial role of metabolic reprogramming in shaping functions innate lymphoid cells (ILCs), which are vital for tissue immunity and homeostasis. As tissue-resident cells, ILCs dynamically respond to local environmental cues, with tissue-derived metabolites such as short-chain fatty acids amino directly modulating their effector functions. The states ILC subsets-ILC1, ILC2, ILC3-are closely linked ability produce cytokines, sustain survival, drive proliferation. This review provides a comprehensive analysis how key pathways, including glycolysis, oxidative phosphorylation, acid oxidation, influence activation function. Furthermore, we explore complex interactions between these pathways tissue-specific metabolites, can shape ILC-mediated immune responses health disease. Understanding reveals new insights into pathogenesis conditions asthma, inflammatory bowel disease, cancer. A deeper understanding mechanisms may not only advance our knowledge disease but also lead development novel therapeutic strategies targeting treat disorders.

Language: Английский

Citations

0
Highlights of 2024: The multifaceted roles of ILC3s in mucosal immunity and inflammation DOI
Shen Xin, Xianzhi Gao, Lie Wang

et al.

Immunology and Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

In this article for the Highlights of 2024 Series, we discuss research on Group 3 innate lymphoid cells (ILC3s), which revealed their complex roles in mucosal immunity and inflammation. ILC3s can migrate from gut to kidneys, contributing renal fibrosis. Their functions are metabolically regulated, with proteins such as nucleophosmin 1 Tox2 influencing oxidative phosphorylation glycolysis, respectively. also express immune checkpoint molecules (e.g. cytotoxic T-lymphocyte antigen 4 programmed cell death1), modulate These findings highlight tissue-specific need targeted immunotherapies.

Language: Английский

Citations

0
Regulation of innate lymphoid cell by microbial metabolites DOI

Hongji Tao,

Jingjing Geng, Long Bai

et al.

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Early Progenitors of Innate Lymphoid Cells (ILC) DOI
Arundhoti Das, Yi Ding, Avinash Bhandoola

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0