Engineering Exosomes from Fibroblast Growth Factor 1 pre-conditioned Adipose-Derived Stem Cells Promote ischemic Skin Flaps Survival by activating Autophagy DOI Creative Commons

Xuanlong Zhang,

Xiaoqiong Jiang,

Huimin Deng

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101314 - 101314

Published: Oct. 28, 2024

The recovery of ischemic skin flaps is a major concern in clinical settings. purpose this study to evaluate the effects engineered exosomes derived from FGF1 pre-conditioned adipose-derived stem cells (FEXO) on flaps. 6 patients who suffered pressure ulcer at stage 4 and underwent surgery were recruited screen potential targets FGF family. was co-incubated with adipose cells, ultracentrifugation applied extract FEXO. Transcriptome sequencing analysis used determine most effective microRNA Animal models established our verify Immunofluorescence (IF), western blotting (WB) other molecular strategy mechanism expected be therapeutic diagnostic target flaps, but there still some deficiency rescuing FEXO significantly improved viability RPSFs endothelial by inhibiting oxidative stress alleviating apoptosis pyroptosis through augmenting autophagy flux. In addition, inhibited over-activated inflammation responses. showed that miR-183-5p elevated FEXO, resulted impaired protective exosomal markedly enhanced cell viability, alleviated targeting GPR137 Pi3k/Akt/mTOR pathway, indicating could also flap. It notabale increased number upregulating VAMP3, which may promising for translation. survivial rate miR-183-5p/GPR137/Pi3k/Akt/mTOR axis, would rescue

Language: Английский

Zn-DHM nanozymes regulate metabolic and immune homeostasis for early diabetic wound therapy DOI
Shuo Zhang, Xinyu Zhao, Wei Zhang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 63 - 84

Published: March 6, 2025

Language: Английский

Citations

2
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment DOI
Douglas Hanahan, Olivier Michielin, Mikaël J. Pittet

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Language: Английский

Citations

13
Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways DOI Creative Commons
Yunlong Fan,

Jiaman Yang,

Yulin Xie

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 17, 2025

Language: Английский

Citations

1
Stemness in solid malignancies: coping with immune attack DOI
Judith Agudo, Yuxuan Miao

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Language: Английский

Citations

8
Exposomal determinants of non-genetic plasticity in tumor initiation DOI

Davide Carra,

Silvana C. E. Maas, José A. Seoane

et al.

Trends in cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis DOI Creative Commons
Peiyan Zhang, Jiawei Wang,

Jinlin Miao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 6, 2025

Tissue resident regulatory T cells (tissue Tregs) are vital for maintaining immune homeostasis and controlling inflammation. They aid in repairing damaged tissues influencing the progression of fibrosis. However, despite extensive research on how tissue Tregs interact with non-immune during repair, their pro- anti-fibrotic effects chronic injury remain unclear. Understanding various cell types, as well roles fibrosis, is crucial uncovering mechanisms behind these conditions. In this review, we describe repair fibrosis across different explore potential strategies regulating homeostasis. These insights hold promise providing new perspectives approaches treatment irreversible fibrotic diseases.

Language: Английский

Citations

0
Transfer of bone marrow niche-residential regulatory T cells ameliorates experimental colitis DOI
Meng Chen, Tatsuyuki Sato,

Ryosuke Ueda

et al.

Cellular Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 104952 - 104952

Published: April 1, 2025

Language: Английский

Citations

0
Regulatory T cells in the context: deciphering the dynamic interplay with the tissue environment DOI

Xiao Jun Huang,

Alexander Y. Rudensky

Current Opinion in Immunology, Journal Year: 2024, Volume and Issue: 89, P. 102453 - 102453

Published: Aug. 1, 2024

Language: Английский

Citations

3
Hair care: Stem cells control immune response during wound repair DOI

Shannon McCarthy,

Judith Agudo

Immunity, Journal Year: 2024, Volume and Issue: 57(5), P. 933 - 935

Published: May 1, 2024

Language: Английский

Citations

1
Engineering Exosomes from Fibroblast Growth Factor 1 pre-conditioned Adipose-Derived Stem Cells Promote ischemic Skin Flaps Survival by activating Autophagy DOI Creative Commons

Xuanlong Zhang,

Xiaoqiong Jiang,

Huimin Deng

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101314 - 101314

Published: Oct. 28, 2024

The recovery of ischemic skin flaps is a major concern in clinical settings. purpose this study to evaluate the effects engineered exosomes derived from FGF1 pre-conditioned adipose-derived stem cells (FEXO) on flaps. 6 patients who suffered pressure ulcer at stage 4 and underwent surgery were recruited screen potential targets FGF family. was co-incubated with adipose cells, ultracentrifugation applied extract FEXO. Transcriptome sequencing analysis used determine most effective microRNA Animal models established our verify Immunofluorescence (IF), western blotting (WB) other molecular strategy mechanism expected be therapeutic diagnostic target flaps, but there still some deficiency rescuing FEXO significantly improved viability RPSFs endothelial by inhibiting oxidative stress alleviating apoptosis pyroptosis through augmenting autophagy flux. In addition, inhibited over-activated inflammation responses. showed that miR-183-5p elevated FEXO, resulted impaired protective exosomal markedly enhanced cell viability, alleviated targeting GPR137 Pi3k/Akt/mTOR pathway, indicating could also flap. It notabale increased number upregulating VAMP3, which may promising for translation. survivial rate miR-183-5p/GPR137/Pi3k/Akt/mTOR axis, would rescue

Language: Английский

Citations

1