Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 5, 2024

Ageing is the principal risk factor for retinal degenerative diseases, which are commonest cause of blindness in developed countries. These conditions include age-related macular degeneration or diabetic retinopathy. Regulatory T cells play a vital role immunoregulation nervous system by limiting inflammation and tissue damage health disease. Because retina was long-considered an immunoprivileged site, precise contribution regulatory homeostasis diseases remains unknown.

Language: Английский

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Harnessing the biology of regulatory T cells to treat disease

Nature Reviews Drug Discovery, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

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Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Feb. 1, 2024

CD4 + CD25 Foxp3 regulatory T cells (Treg) have been implicated in pain modulation various inflammatory conditions. However, whether Treg hamper at steady state and by which mechanism is still unclear. From a meta-analysis of the transcriptomes murine conventional (Tconv), we observe that proenkephalin gene ( Penk ), encoding precursor analgesic opioid peptides, ranks among top 25 genes most enriched cells. We then present evidence suggesting regulated part members Tumor Necrosis Factor Receptor (TNFR) family transcription factor Basic leucine zipper faatf-like (BATF). Using mice promoter activity can be tracked with fluorescent reporter, also show expression mostly detected activated Tconv non-inflammatory conditions colon skin. Functionally, proficient or deficient for suppress equally well proliferation effector vitro autoimmune colitis vivo. In contrast, inducible ablation leads to heat hyperalgesia both male female mice. Overall, our results indicate might play key role modulating basal somatic sensitivity through production peptides.

Language: Английский

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Damping excessive viral-induced IFN-γ rescues the impaired anti-Aspergillus host immune response in influenza-associated pulmonary aspergillosis

EBioMedicine, Journal Year: 2024, Volume and Issue: 108, P. 105347 - 105347

Published: Sept. 30, 2024

Language: Английский

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Understanding Liver Transplantation Outcomes Through the Lens of Its Tissue-resident Immunobiome

Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Tissue-resident lymphocytes (TRLs) provide a front-line immunological defense mechanism uniquely placed to detect perturbations in tissue homeostasis. The heterogeneous TRL population spans the innate adaptive immune continuum, with roles during normal physiology homeostatic maintenance, repair, pathogen detection, and rapid mounting of responses. TRLs are especially enriched liver, every subset represented, including liver-resident natural killer cells; tissue-resident memory B conventional CD8, CD4, regulatory T unconventional gamma-delta, killer, mucosal-associated invariant cells. importance donor- recipient-derived after transplantation is becoming increasingly recognized, although it has not been examined detail liver transplantation. This review summarizes evidence for transplant immunology, focusing on their features, functions, potential harnessing improve outcomes.

Language: Английский

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Dynamics of tissue repair regulatory T cells and damage in acute Trypanosoma cruzi infection

PLoS Pathogens, Journal Year: 2025, Volume and Issue: 21(1), P. e1012906 - e1012906

Published: Jan. 30, 2025

Tissue-repair regulatory T cells (trTregs) comprise a specialized cell subset essential for tissue homeostasis and repair. While well-studied in sterile injury models, their role infection-induced damage antimicrobial immunity is less understood. We investigated trTreg dynamics during acute Trypanosoma cruzi infection, marked by extensive strong CD8+ immunity. Unlike trTregs significantly declined secondary lymphoid organs non-lymphoid target tissues correlating with systemic local damage, downregulation of function-associated genes skeletal muscle. This decline was linked to decreased IL-33 levels, key growth factor, promoted the Th1 cytokine IFN-γ. Early recombinant treatment increased trTregs, type 2 innate cells, parasite-specific at specific time points after leading reduced lower parasite burden, improved disease outcome. Our findings not only provide novel insights into infection but also highlight potential optimizing immune balance modulating responses promote repair while maintaining effective pathogen control injury.

Language: Английский

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Nanoparticle troopers: Infiltrating cancer cells for targeted therapies

Nano-Structures & Nano-Objects, Journal Year: 2025, Volume and Issue: 41, P. 101453 - 101453

Published: Feb. 1, 2025

Language: Английский

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The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 6, 2025

Tissue resident regulatory T cells (tissue Tregs) are vital for maintaining immune homeostasis and controlling inflammation. They aid in repairing damaged tissues influencing the progression of fibrosis. However, despite extensive research on how tissue Tregs interact with non-immune during repair, their pro- anti-fibrotic effects chronic injury remain unclear. Understanding various cell types, as well roles fibrosis, is crucial uncovering mechanisms behind these conditions. In this review, we describe repair fibrosis across different explore potential strategies regulating homeostasis. These insights hold promise providing new perspectives approaches treatment irreversible fibrotic diseases.

Language: Английский

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Regulatory T cell therapy in autoimmune liver disease and transplantation

JHEP Reports, Journal Year: 2025, Volume and Issue: unknown, P. 101394 - 101394

Published: March 1, 2025

Language: Английский

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Site-dependent Treg cell transcriptional reprograming in a metastatic colorectal cancer model holds prognostic significance

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Abstract In colorectal cancer (CRC), tumor-infiltrating regulatory T (Treg) cells suppress anti-tumor immunity, promoting immune evasion and tumor progression. Effective therapies require selectively targeting Treg (TI-Treg) while preserving systemic cells, necessitating insight into their adaptations within the microenvironment. Here, CRC-organoids were implanted in liver of Foxp3eGFP mice to investigate location-specific phenotypic differences TI-Treg cells. Tumor tissue exhibited an increased proportion a decrease effector CD4⁺ CD8⁺ compared matched healthy tissue. RNA sequencing isolated from spleen, primary transplant, or metastases identified gene expression profiles previously associated with CRC-related patients. Location-specific included elevated WNT-pathway genes peritoneal counterparts. Higher upregulated correlated poor CRC prognosis. Splenic tumor-bearing displayed distinct transcriptional both counterparts suggesting they represent CD4 + population. Taken together, these findings highlight heterogeneity across different sites nature splenic hosts.

Language: Английский

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