Carrot-Derived Rhamnogalacturonan-I Consistently Increases the Microbial Production of Health-Promoting Indole-3-Propionic Acid Ex Vivo DOI Creative Commons
Annick Mercenier, Lam Dai Vu, Jonas Poppe

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 722 - 722

Published: Dec. 21, 2024

Background: Using dietary interventions to steer the metabolic output of gut microbiota towards specific health-promoting metabolites is often challenging due interpersonal variation in treatment responses. Methods: In this study, we combined ex vivo SIFR® (Systemic Intestinal Fermentation Research) technology with untargeted metabolite profiling investigate impact carrot-derived rhamnogalacturonan-I (cRG-I) on production by 24 human adults. Results: The findings reveal that at a dose equivalent 1.5 g/d, cRG-I consistently promoted indole-3-propionic acid (IPA) (+45.8% increase) across all subjects. At 0.3 increased IPA was also observed (+14.6%), which comparable effect seen for g/d inulin (10.6%). has been shown provide protection against diseases affecting and multiple organs. Pearson correlation analysis revealed strong (R = 0.65, padjusted 6.1 × 10−16) between increases levels absolute Bifidobacterium longum, producer indole-3-lactic (ILA), an intermediate production. Finally, community modulation score, novel diversity index, demonstrated maintained high α-diversity previously linked elevated Conclusions: results from experiment mirrored clinical outcomes provided insights into microbiome function. Importantly, promotes tryptophan conversion via modulation, thus conferring benefits amino derived extending beyond those reported short chain fatty acids (SCFA) resulting carbohydrate fermentation.

Language: Английский

Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age DOI Creative Commons
Julia A. Brown, Hilal Bashir, Melody Yue Zeng

et al.

Mucosal Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Role of the microbiome in regulation of the immune system DOI Creative Commons
Songhui Kim,

Cebile Ndwandwe,

Hannah Devotta

et al.

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Immune health and metabolic functions are intimately connected via diet the microbiota. cells continuously exposed to a wide range of microbes microbial-derived compounds, with important mucosal systemic ramifications. Microbial fermentation dietary components in vivo generates thousands molecules, some which integral molecular circuitry that regulates immune functions. These turn protect against aberrant inflammatory or hyper-reactive processes promote effector responses quickly eliminate pathogens, such as SARS-CoV-2. Potent tolerance mechanisms should ensure these do not over-react non-pathogenic factors (e.g. food proteins), while maintaining ability respond infectious challenges robust, effective well controlled manner. In this review we examine shape microbiota composition interactions host system, their associations mediated disorders strategies for intervention.

Language: Английский

Citations

1
The gut-lung axis: Protozoa join the party DOI
Nicola L. Harris, Benjamin J. Marsland

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Microbial influencers: the airway microbiome’s role in asthma DOI Creative Commons
Young Jin Kim, Supinda Bunyavanich

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(4)

Published: Feb. 16, 2025

Asthma is a common chronic respiratory disease affecting people of all ages globally. The airway hosts diverse microbial communities increasingly recognized as influential in the development and course asthma. Here, we review recent findings on microbiome As relationships between health take root early life, first provide an overview early-life asthma development, where multiple cohort studies have identified bacterial genera infant associated with risk future wheeze We then address current understandings interactions environmental factors, microbiome, asthma, including effects rural/urban environments, pet ownership, smoking, viral illness, antibiotics. Next, delve into what has been observed about phenotypes endotypes, microbiota control, severity, obesity-related treatment well type 2 high, low, more newly described multi-omic endotypes. discuss emerging approaches to shape for therapy conclude Review perspectives research directions.

Language: Английский

Citations

0
Early‐Life Host–Microbial Interactions and Asthma Development: A Lifelong Impact? DOI Creative Commons
Céline Pattaroni, Benjamin J. Marsland, Nicola L. Harris

et al.

Immunological Reviews, Journal Year: 2025, Volume and Issue: 330(1)

Published: March 1, 2025

ABSTRACT Childhood is a multifactorial disease, and recent research highlights the influence of early‐life microbial communities in shaping disease risk. This review explores roles gut respiratory microbiota asthma development, emphasizing importance early exposure. The has been particularly well studied, with certain taxa like Faecalibacterium Bifidobacterium linked to protection, whereas short‐chain fatty acids produced by microbes support immune tolerance through gut–lung axis. In contrast, microbiota, though low biomass, shows consistent associations between bacterial colonization Streptococcus , Moraxella Haemophilus increased also addresses emerging skin environmental fungi asthma, findings remain inconsistent. Timing critical factor, disruptions, such as antibiotic use, potentially leading Despite significant advances, there are still unresolved questions about long‐term consequences perturbations, regarding whether dysbiosis cause or consequence asthma. integrates current findings, highlighting need for deeper investigation into cross‐organ interactions exposures understand childhood pathophysiology.

Language: Английский

Citations

0
Gut flora-derived succinate exacerbates Allergic Airway Inflammation by promoting protein succinylation DOI Creative Commons
Chao Wang, Xin Yu, Yu Xiao

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103623 - 103623

Published: March 1, 2025

Allergic airway inflammation (AAI) is a prevalent respiratory disorder that affects vast number of individuals globally. There exists complex interplay among inflammation, immune responses, and metabolic processes, which paramount importance in the pathogenesis AAI. Metabolic dysregulation protein translational modification (PTM) are well-recognized hallmarks diseases, playing pivotal roles onset progression numerous ailments. However, role gut microbiota metabolites development AAI, as well their influence on PTM modifications within this disease context, have not been thoroughly explored investigated thus far. In AAI patients, succinate was identified key metabolite, positively correlated with certain parameters IgE levels, having good diagnostic value. mice, bacteria were main source high levels. Mendelian randomization showed risk factor for asthma. Exogenous worsened increasing resistance inflammatory Protein succinylation mice lungs differed significantly from normal up-regulated proteins pathways. FMT alleviated symptoms by reducing vitro, promoted BEAS-2B cells, SOD2 succinylated protein, K68 site crucial its enzyme activity regulation. Gut flora-derived exacerbates lung succinylation, can reverse this. These findings offer new insights into mechanisms potential therapeutic targets.

Language: Английский

Citations

0
Fusobacterium nucleatum Derived 3-Indolepropionic acid Promotes Colorectal Cancer Progression via Aryl Hydrocarbon Receptor Activation in Macrophages DOI
Qi Song, Zhiliang Jin, Han Zhang

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111495 - 111495

Published: March 1, 2025

Language: Английский

Citations

0
Modulation of Host Immunity by Microbiome‐Derived Indole‐3‐Propionic Acid and Other Bacterial Metabolites DOI Creative Commons
Burkhard Schütz,

Felix F. Krause,

R. Verena Taudte

et al.

European Journal of Immunology, Journal Year: 2025, Volume and Issue: 55(4)

Published: April 1, 2025

In recent years, we have witnessed a rapidly growing interest in the intricate communications between intestinal microorganisms and host immune system. Research on human microbiome is evolving from merely descriptive correlative studies to deeper mechanistic understanding of bidirectional interactions gut microbiota mucosal Despite numerous challenges, it has become increasingly evident that an imbalance composition, known as dysbiosis, associated with development progression various metabolic, immune, cancer, neurodegenerative disorders. A body evidence highlights importance small molecules produced by commensal bacteria, collectively referred microbial metabolites. These metabolites serve crucial diffusible messengers, translating language cells. This review aims explore complex not yet fully understood molecular mechanisms through which microbiota-derived influence activity cells shape reactions other organs. Specifically, will discuss research reveals close relationship indole-3-propionic acid (IPA) immunity. Furthermore, emphasize beneficial effects IPA inflammation its potential clinical implications.

Language: Английский

Citations

0
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota DOI Creative Commons
Yanbo Liu, Ying Zhou, Haoyue Zhang

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

Citations

0
Florfenicol-induced dysbiosis impairs intestinal homeostasis and host immune system in laying hens DOI Creative Commons
Keesun Yu, Inhwan Choi, Minseong Kim

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 14, 2025

Language: Английский

Citations

0